High bone mineral apparent density in children with X-linked hypophosphatemia

TY - JOUR

T1 - High bone mineral apparent density in children with X-linked hypophosphatemia

AU - Beck-Nielsen, Signe

AU - Brixen, K

AU - Gram, J

AU - Mølgaard, Christian

N1 - CURIS 2013 NEXS 146

PY - 2013/8

Y1 - 2013/8

N2 - Bone mineral apparent density (BMAD) in children with X-linked hypophosphatemia (XLH) was evaluated, as they are unlikely to have extra-skeletal ossifications contributing to the elevated bone mineral density of the spine in adult patients. Children with XLH also had significantly higher BMAD of the spine compared to femoral neck. INTRODUCTION: BMAD obtained by dual-energy X-ray absorptiometry scans in children with XLH was evaluated, as they are unlikely to have the extra-skeletal ossifications contributing to the elevated bone mineral density of the spine in adult patients. METHODS: A total of 15 children with biochemically and genetically verified XLH were recruited. Anthropometric measurements were performed, and to correct for the short stature (small bones), the BMAD of the spine and the femoral neck was evaluated. RESULTS: Z-scores of BMAD of the spine (mean (95 % CI); 2.0 (1.3-2.7); p 

AB - Bone mineral apparent density (BMAD) in children with X-linked hypophosphatemia (XLH) was evaluated, as they are unlikely to have extra-skeletal ossifications contributing to the elevated bone mineral density of the spine in adult patients. Children with XLH also had significantly higher BMAD of the spine compared to femoral neck. INTRODUCTION: BMAD obtained by dual-energy X-ray absorptiometry scans in children with XLH was evaluated, as they are unlikely to have the extra-skeletal ossifications contributing to the elevated bone mineral density of the spine in adult patients. METHODS: A total of 15 children with biochemically and genetically verified XLH were recruited. Anthropometric measurements were performed, and to correct for the short stature (small bones), the BMAD of the spine and the femoral neck was evaluated. RESULTS: Z-scores of BMAD of the spine (mean (95 % CI); 2.0 (1.3-2.7); p 

U2 - 10.1007/s00198-013-2286-9

DO - 10.1007/s00198-013-2286-9

M3 - Journal article

C2 - 23389694

SN - 0937-941X

VL - 24

SP - 2215

EP - 2221

JO - Osteoporosis International

JF - Osteoporosis International

IS - 8

ER -