Heterogeneity and plasticity of epidermal stem cells

Troels Schepeler; Mahalia E Page; Kim Bak Jensen

doi:10.1242/dev.104588

Heterogeneity and plasticity of epidermal stem cells

Troels Schepeler, Mahalia E Page, Kim Bak Jensen

67 Citationer (Scopus)

Abstract

The epidermis is an integral part of our largest organ, the skin, and protects us against the hostile environment. It is a highly dynamic tissue that, during normal steady-state conditions, undergoes constant turnover. Multiple stem cell populations residing in autonomously maintained compartments facilitate this task. In this Review, we discuss stem cell behaviour during normal tissue homeostasis, regeneration and disease within the pilosebaceous unit, an integral structure of the epidermis that is responsible for hair growth and lubrication of the epithelium. We provide an up-to-date view of the pilosebaceous unit, encompassing the heterogeneity and plasticity of multiple discrete stem cell populations that are strongly influenced by external cues to maintain their identity and function.

Originalsprog	Engelsk
Tidsskrift	Development (Cambridge, England)
Vol/bind	141
Udgave nummer	13
Sider (fra-til)	2559-2567
Antal sider	9
ISSN	0950-1991
DOI	https://doi.org/10.1242/dev.104588
Status	Udgivet - jul. 2014

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10.1242/dev.104588

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AB - The epidermis is an integral part of our largest organ, the skin, and protects us against the hostile environment. It is a highly dynamic tissue that, during normal steady-state conditions, undergoes constant turnover. Multiple stem cell populations residing in autonomously maintained compartments facilitate this task. In this Review, we discuss stem cell behaviour during normal tissue homeostasis, regeneration and disease within the pilosebaceous unit, an integral structure of the epidermis that is responsible for hair growth and lubrication of the epithelium. We provide an up-to-date view of the pilosebaceous unit, encompassing the heterogeneity and plasticity of multiple discrete stem cell populations that are strongly influenced by external cues to maintain their identity and function.

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ER -

Heterogeneity and plasticity of epidermal stem cells

Abstract

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