TY - JOUR
T1 - Healthy ageing
T2 - the beneficial effect of dietary supplementation with alpha-ketoglutarate on arterial elasticity in elderly mice
AU - Harrison, Adrian Paul
AU - Brüggemann, Dagmar Adeline
AU - Bartels, Else Marie
AU - Andrea, Kathrine
AU - Pierzynowski, Stefan
PY - 2009
Y1 - 2009
N2 - The study employed mechanical stretching in vitro of sections of abdominal aorta of elderly mice to investigate any benefits of oral treatment with alpha-ketoglutarate (AKG) on arterial elasticity. Eighteen female mice (50-weeks-old) were assigned to a control (2% w/v) Na2-AKG or (2% w/v) a Ca-AKG group, and treated for 182 days before being humanely killed. Aorta sections were exposed to increases in force (0.09 N) giving approx. 6 kPa of pressure, after which elastic recoil (N ms-1 wet wt.) was measured. Na2-AKG treatment for 182 days induced a 30% (P <0.01) improvement, while Ca-AKG induced a 93% (P <0.001) improvement in the elastic recoil compared to controls (3.30 ± 0.08 x 10-5 N ms-1 mg-1 wet wt.). AKG administered orally improved arterial elasticity in elderly mice, a change that occurred despite an increase in total collagen content. Alpha-ketoglutarate warrants further investigation as a candidate for therapies targeting arterial stiffening with age.
AB - The study employed mechanical stretching in vitro of sections of abdominal aorta of elderly mice to investigate any benefits of oral treatment with alpha-ketoglutarate (AKG) on arterial elasticity. Eighteen female mice (50-weeks-old) were assigned to a control (2% w/v) Na2-AKG or (2% w/v) a Ca-AKG group, and treated for 182 days before being humanely killed. Aorta sections were exposed to increases in force (0.09 N) giving approx. 6 kPa of pressure, after which elastic recoil (N ms-1 wet wt.) was measured. Na2-AKG treatment for 182 days induced a 30% (P <0.01) improvement, while Ca-AKG induced a 93% (P <0.001) improvement in the elastic recoil compared to controls (3.30 ± 0.08 x 10-5 N ms-1 mg-1 wet wt.). AKG administered orally improved arterial elasticity in elderly mice, a change that occurred despite an increase in total collagen content. Alpha-ketoglutarate warrants further investigation as a candidate for therapies targeting arterial stiffening with age.
M3 - Journal article
SN - 1898-2395
VL - 3
SP - 1
EP - 10
JO - The Journal of Pre-Clinical and Clinical Research
JF - The Journal of Pre-Clinical and Clinical Research
IS - 1
ER -