Health Effects of PCBs in Residences and Schools (HESPERUS): PCB - health Cohort Profile

Elvira Vaclavik Bräuner; Zorana Jovanovic Andersen; Marie Frederiksen; Ina Olmer Specht; Karin Sørig Hougaard; Niels Ebbehøj; Janice Bailey; Aleksander Giwercman; Kyle Steenland; Matthew Paul Longnecker; Jens Peter Bonde

doi:10.1038/srep24571

Health Effects of PCBs in Residences and Schools (HESPERUS): PCB - health Cohort Profile

Elvira Vaclavik Bräuner, Zorana Jovanovic Andersen, Marie Frederiksen, Ina Olmer Specht, Karin Sørig Hougaard, Niels Ebbehøj, Janice Bailey, Aleksander Giwercman, Kyle Steenland, Matthew Paul Longnecker, Jens Peter Bonde

9 Citationer (Scopus)

Abstract

Polychlorinated-biphenyls (PCBs) were introduced in the late 1920s and used until the 1970s when they were banned in most countries due to evidence of environmental build-up and possible adverse health effects. However they still persist in the environment, indoors and in humans. Indoor air in contaminated buildings may confer airborne exposure markedly above background regional PCB levels. To date, no epidemiological studies have assessed the health effects from exposure to semi-volatile PCBs in the indoor environment. Indoor air PCBs are generally less chlorinated than PCBs that are absorbed via the diet, or via past occupational exposure; therefore their health effects require separate risk assessment. Two separate cohorts of individuals who have either attended schools (n = 66,769; 26% exposed) or lived in apartment buildings (n = 37,185; 19% exposed), where indoor air PCB concentrations have been measured were created. An individual estimate of long-term airborne PCB exposure was assigned based on measurements. The cohorts will be linked to eight different national data sources on mortality, school records, residential history, socioeconomic status, and chronic disease and reproductive outcomes. The linking of indoor air exposures with health outcomes provides a dataset unprecedented worldwide. We describe a project, called HESPERUS (Health Effects of PCBs in Residences and Schools), which will be the first study of the long term health effects of the lower-chlorinated, semi-volatile PCBs in the indoor environment.

Originalsprog	Engelsk
Artikelnummer	24571
Tidsskrift	Scientific Reports
Vol/bind	6
Sider (fra-til)	1-10
Antal sider	10
ISSN	2045-2322
DOI	https://doi.org/10.1038/srep24571
Status	Udgivet - 19 apr. 2016

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10.1038/srep24571Licens: CC BY

Citationsformater

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abstract = "Polychlorinated-biphenyls (PCBs) were introduced in the late 1920s and used until the 1970s when they were banned in most countries due to evidence of environmental build-up and possible adverse health effects. However they still persist in the environment, indoors and in humans. Indoor air in contaminated buildings may confer airborne exposure markedly above background regional PCB levels. To date, no epidemiological studies have assessed the health effects from exposure to semi-volatile PCBs in the indoor environment. Indoor air PCBs are generally less chlorinated than PCBs that are absorbed via the diet, or via past occupational exposure; therefore their health effects require separate risk assessment. Two separate cohorts of individuals who have either attended schools (n = 66,769; 26% exposed) or lived in apartment buildings (n = 37,185; 19% exposed), where indoor air PCB concentrations have been measured were created. An individual estimate of long-term airborne PCB exposure was assigned based on measurements. The cohorts will be linked to eight different national data sources on mortality, school records, residential history, socioeconomic status, and chronic disease and reproductive outcomes. The linking of indoor air exposures with health outcomes provides a dataset unprecedented worldwide. We describe a project, called HESPERUS (Health Effects of PCBs in Residences and Schools), which will be the first study of the long term health effects of the lower-chlorinated, semi-volatile PCBs in the indoor environment.",

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AU - Bräuner, Elvira Vaclavik

AU - Andersen, Zorana Jovanovic

AU - Frederiksen, Marie

AU - Specht, Ina Olmer

AU - Hougaard, Karin Sørig

AU - Ebbehøj, Niels

AU - Bailey, Janice

AU - Giwercman, Aleksander

AU - Steenland, Kyle

AU - Longnecker, Matthew Paul

AU - Bonde, Jens Peter

PY - 2016/4/19

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N2 - Polychlorinated-biphenyls (PCBs) were introduced in the late 1920s and used until the 1970s when they were banned in most countries due to evidence of environmental build-up and possible adverse health effects. However they still persist in the environment, indoors and in humans. Indoor air in contaminated buildings may confer airborne exposure markedly above background regional PCB levels. To date, no epidemiological studies have assessed the health effects from exposure to semi-volatile PCBs in the indoor environment. Indoor air PCBs are generally less chlorinated than PCBs that are absorbed via the diet, or via past occupational exposure; therefore their health effects require separate risk assessment. Two separate cohorts of individuals who have either attended schools (n = 66,769; 26% exposed) or lived in apartment buildings (n = 37,185; 19% exposed), where indoor air PCB concentrations have been measured were created. An individual estimate of long-term airborne PCB exposure was assigned based on measurements. The cohorts will be linked to eight different national data sources on mortality, school records, residential history, socioeconomic status, and chronic disease and reproductive outcomes. The linking of indoor air exposures with health outcomes provides a dataset unprecedented worldwide. We describe a project, called HESPERUS (Health Effects of PCBs in Residences and Schools), which will be the first study of the long term health effects of the lower-chlorinated, semi-volatile PCBs in the indoor environment.

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Health Effects of PCBs in Residences and Schools (HESPERUS): PCB - health Cohort Profile

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