Hazelnut allergy: a double-blind, placebo-controlled food challenge multicenter study

C Ortolani; B K Ballmer-Weber; K S Hansen; M Ispano; B Wüthrich; C Bindslev-Jensen; R Ansaloni; L Vannucci; V Pravettoni; J Scibilia; L K Poulsen; E A Pastorello

doi:10.1067/mai.2000.103052

Hazelnut allergy: a double-blind, placebo-controlled food challenge multicenter study

C Ortolani, B K Ballmer-Weber, K S Hansen, M Ispano, B Wüthrich, C Bindslev-Jensen, R Ansaloni, L Vannucci, V Pravettoni, J Scibilia, L K Poulsen, E A Pastorello

Institut for Klinisk Medicin

135 Citationer (Scopus)

Abstract

BACKGROUND: Tree nuts are a common cause of food allergy in Europe. However, few studies deal with real food allergy to hazelnuts in subjects believed to be allergic to this food.

OBJECTIVE: We sought to select subjects with a history of allergic reactions on ingestion of hazelnut and determine how many of these have true allergy by means of the double-blind, placebo-controlled food challenge (DBPCFC).

METHODS: Eighty-six subjects with a history of symptoms after hazelnut ingestion were recruited from 3 allergy centers (Milan, Zurich, and Copenhagen). All subjects underwent skin prick tests (SPTs) with aeroallergens and hazelnut, as well as having their specific hazelnut IgE levels determined. Diagnosis of clinical relevant food allergy was made on the basis of the DBPCFC.

RESULTS: Sixty-seven (77.9%) of 86 subjects had a positive DBPCFC result; 8 were placebo responders, and 11 were nonresponders. Of the 11 nonresponders, 4 had positive open-challenge test results. Of the DBPCFC-positive subjects, 87% also had positive skin test responses to birch pollen extract. Specific IgE determination for hazelnut (positive CAP response >/=0.7 kU/L [ie, class 2]) showed a sensitivity of 0.75, a positive predictive value (PPV) of 0.92, a specificity of 0.16, and a negative predictive value (NPV) of 0.05. Skin tests with commercial hazelnut extract produced a sensitivity of 0.89, a PPV of 0.92, a specificity of 0.05, and an NPV of 0.05. Skin tests with natural food produced a sensitivity of 0.88, a PPV of 0.94, a specificity of 0.27, and an NPV of 0.15.

CONCLUSION: This study shows that hazelnut is an allergenic source that can cause real food allergy, as confirmed by DBPCFC. Skin and IgE tests demonstrated reasonable sensitivity and PPV but a very low specificity and NPV, thus implying that these should not be used to validate the diagnosis of food allergy to hazelnut.

Originalsprog	Engelsk
Tidsskrift	The Journal of allergy and clinical immunology
Vol/bind	105
Udgave nummer	3
Sider (fra-til)	577-81
Antal sider	5
ISSN	0091-6749
DOI	https://doi.org/10.1067/mai.2000.103052
Status	Udgivet - mar. 2000

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10.1067/mai.2000.103052

Citationsformater

Ortolani, C., Ballmer-Weber, B. K., Hansen, K. S., Ispano, M., Wüthrich, B., Bindslev-Jensen, C., Ansaloni, R., Vannucci, L., Pravettoni, V., Scibilia, J., Poulsen, L. K., & Pastorello, E. A. (2000). Hazelnut allergy: a double-blind, placebo-controlled food challenge multicenter study. The Journal of allergy and clinical immunology, 105(3), 577-81. https://doi.org/10.1067/mai.2000.103052

Ortolani, C, Ballmer-Weber, BK, Hansen, KS, Ispano, M, Wüthrich, B, Bindslev-Jensen, C, Ansaloni, R, Vannucci, L, Pravettoni, V, Scibilia, J, Poulsen, LK & Pastorello, EA 2000, 'Hazelnut allergy: a double-blind, placebo-controlled food challenge multicenter study', The Journal of allergy and clinical immunology, bind 105, nr. 3, s. 577-81. https://doi.org/10.1067/mai.2000.103052

@article{ee2386906ce948f8bfc93361dd3cab85,

title = "Hazelnut allergy: a double-blind, placebo-controlled food challenge multicenter study",

abstract = "BACKGROUND: Tree nuts are a common cause of food allergy in Europe. However, few studies deal with real food allergy to hazelnuts in subjects believed to be allergic to this food.OBJECTIVE: We sought to select subjects with a history of allergic reactions on ingestion of hazelnut and determine how many of these have true allergy by means of the double-blind, placebo-controlled food challenge (DBPCFC).METHODS: Eighty-six subjects with a history of symptoms after hazelnut ingestion were recruited from 3 allergy centers (Milan, Zurich, and Copenhagen). All subjects underwent skin prick tests (SPTs) with aeroallergens and hazelnut, as well as having their specific hazelnut IgE levels determined. Diagnosis of clinical relevant food allergy was made on the basis of the DBPCFC.RESULTS: Sixty-seven (77.9%) of 86 subjects had a positive DBPCFC result; 8 were placebo responders, and 11 were nonresponders. Of the 11 nonresponders, 4 had positive open-challenge test results. Of the DBPCFC-positive subjects, 87% also had positive skin test responses to birch pollen extract. Specific IgE determination for hazelnut (positive CAP response >/=0.7 kU/L [ie, class 2]) showed a sensitivity of 0.75, a positive predictive value (PPV) of 0.92, a specificity of 0.16, and a negative predictive value (NPV) of 0.05. Skin tests with commercial hazelnut extract produced a sensitivity of 0.89, a PPV of 0.92, a specificity of 0.05, and an NPV of 0.05. Skin tests with natural food produced a sensitivity of 0.88, a PPV of 0.94, a specificity of 0.27, and an NPV of 0.15.CONCLUSION: This study shows that hazelnut is an allergenic source that can cause real food allergy, as confirmed by DBPCFC. Skin and IgE tests demonstrated reasonable sensitivity and PPV but a very low specificity and NPV, thus implying that these should not be used to validate the diagnosis of food allergy to hazelnut.",

keywords = "Adolescent, Adult, Double-Blind Method, Female, Food Hypersensitivity, Humans, Male, Middle Aged, Nuts, Placebos, Predictive Value of Tests, Skin Tests, Clinical Trial, Controlled Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't",

author = "C Ortolani and Ballmer-Weber, {B K} and Hansen, {K S} and M Ispano and B W{\"u}thrich and C Bindslev-Jensen and R Ansaloni and L Vannucci and V Pravettoni and J Scibilia and Poulsen, {L K} and Pastorello, {E A}",

year = "2000",

month = mar,

doi = "10.1067/mai.2000.103052",

language = "English",

volume = "105",

pages = "577--81",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Mosby Inc.",

number = "3",

}

TY - JOUR

T1 - Hazelnut allergy

T2 - a double-blind, placebo-controlled food challenge multicenter study

AU - Ortolani, C

AU - Ballmer-Weber, B K

AU - Hansen, K S

AU - Ispano, M

AU - Wüthrich, B

AU - Bindslev-Jensen, C

AU - Ansaloni, R

AU - Vannucci, L

AU - Pravettoni, V

AU - Scibilia, J

AU - Poulsen, L K

AU - Pastorello, E A

PY - 2000/3

Y1 - 2000/3

N2 - BACKGROUND: Tree nuts are a common cause of food allergy in Europe. However, few studies deal with real food allergy to hazelnuts in subjects believed to be allergic to this food.OBJECTIVE: We sought to select subjects with a history of allergic reactions on ingestion of hazelnut and determine how many of these have true allergy by means of the double-blind, placebo-controlled food challenge (DBPCFC).METHODS: Eighty-six subjects with a history of symptoms after hazelnut ingestion were recruited from 3 allergy centers (Milan, Zurich, and Copenhagen). All subjects underwent skin prick tests (SPTs) with aeroallergens and hazelnut, as well as having their specific hazelnut IgE levels determined. Diagnosis of clinical relevant food allergy was made on the basis of the DBPCFC.RESULTS: Sixty-seven (77.9%) of 86 subjects had a positive DBPCFC result; 8 were placebo responders, and 11 were nonresponders. Of the 11 nonresponders, 4 had positive open-challenge test results. Of the DBPCFC-positive subjects, 87% also had positive skin test responses to birch pollen extract. Specific IgE determination for hazelnut (positive CAP response >/=0.7 kU/L [ie, class 2]) showed a sensitivity of 0.75, a positive predictive value (PPV) of 0.92, a specificity of 0.16, and a negative predictive value (NPV) of 0.05. Skin tests with commercial hazelnut extract produced a sensitivity of 0.89, a PPV of 0.92, a specificity of 0.05, and an NPV of 0.05. Skin tests with natural food produced a sensitivity of 0.88, a PPV of 0.94, a specificity of 0.27, and an NPV of 0.15.CONCLUSION: This study shows that hazelnut is an allergenic source that can cause real food allergy, as confirmed by DBPCFC. Skin and IgE tests demonstrated reasonable sensitivity and PPV but a very low specificity and NPV, thus implying that these should not be used to validate the diagnosis of food allergy to hazelnut.

AB - BACKGROUND: Tree nuts are a common cause of food allergy in Europe. However, few studies deal with real food allergy to hazelnuts in subjects believed to be allergic to this food.OBJECTIVE: We sought to select subjects with a history of allergic reactions on ingestion of hazelnut and determine how many of these have true allergy by means of the double-blind, placebo-controlled food challenge (DBPCFC).METHODS: Eighty-six subjects with a history of symptoms after hazelnut ingestion were recruited from 3 allergy centers (Milan, Zurich, and Copenhagen). All subjects underwent skin prick tests (SPTs) with aeroallergens and hazelnut, as well as having their specific hazelnut IgE levels determined. Diagnosis of clinical relevant food allergy was made on the basis of the DBPCFC.RESULTS: Sixty-seven (77.9%) of 86 subjects had a positive DBPCFC result; 8 were placebo responders, and 11 were nonresponders. Of the 11 nonresponders, 4 had positive open-challenge test results. Of the DBPCFC-positive subjects, 87% also had positive skin test responses to birch pollen extract. Specific IgE determination for hazelnut (positive CAP response >/=0.7 kU/L [ie, class 2]) showed a sensitivity of 0.75, a positive predictive value (PPV) of 0.92, a specificity of 0.16, and a negative predictive value (NPV) of 0.05. Skin tests with commercial hazelnut extract produced a sensitivity of 0.89, a PPV of 0.92, a specificity of 0.05, and an NPV of 0.05. Skin tests with natural food produced a sensitivity of 0.88, a PPV of 0.94, a specificity of 0.27, and an NPV of 0.15.CONCLUSION: This study shows that hazelnut is an allergenic source that can cause real food allergy, as confirmed by DBPCFC. Skin and IgE tests demonstrated reasonable sensitivity and PPV but a very low specificity and NPV, thus implying that these should not be used to validate the diagnosis of food allergy to hazelnut.

KW - Adolescent

KW - Adult

KW - Double-Blind Method

KW - Female

KW - Food Hypersensitivity

KW - Humans

KW - Male

KW - Middle Aged

KW - Nuts

KW - Placebos

KW - Predictive Value of Tests

KW - Skin Tests

KW - Clinical Trial

KW - Controlled Clinical Trial

KW - Journal Article

KW - Multicenter Study

KW - Research Support, Non-U.S. Gov't

U2 - 10.1067/mai.2000.103052

DO - 10.1067/mai.2000.103052

M3 - Journal article

C2 - 10719310

SN - 0091-6749

VL - 105

SP - 577

EP - 581

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 3

ER -

Hazelnut allergy: a double-blind, placebo-controlled food challenge multicenter study

Abstract

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