Gut-Brain Cross-Talk in Metabolic Control

Christoffer Clemmensen; Timo D Müller; Stephen C Woods; Hans-Rudolf Berthoud; Randy J Seeley; Matthias H Tschöp

doi:10.1016/j.cell.2017.01.025

Gut-Brain Cross-Talk in Metabolic Control

Christoffer Clemmensen, Timo D Müller, Stephen C Woods, Hans-Rudolf Berthoud, Randy J Seeley, Matthias H Tschöp

105 Citationer (Scopus)

Abstract

Because human energy metabolism evolved to favor adiposity over leanness, the availability of palatable, easily attainable, and calorically dense foods has led to unprecedented levels of obesity and its associated metabolic co-morbidities that appear resistant to traditional lifestyle interventions. However, recent progress identifying the molecular signaling pathways through which the brain and the gastrointestinal system communicate to govern energy homeostasis, combined with emerging insights on the molecular mechanisms underlying successful bariatric surgery, gives reason to be optimistic that novel precision medicines that mimic, enhance, and/or modulate gut-brain signaling can have unprecedented potential for stopping the obesity and type 2 diabetes pandemics.

Originalsprog	Engelsk
Tidsskrift	Cell
Vol/bind	168
Udgave nummer	5
Sider (fra-til)	758-774
Antal sider	17
ISSN	0092-8674
DOI	https://doi.org/10.1016/j.cell.2017.01.025
Status	Udgivet - 23 feb. 2017
Udgivet eksternt	Ja

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10.1016/j.cell.2017.01.025

http://www.cell.com/article/S0092867417301101/pdf

Citationsformater

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abstract = "Because human energy metabolism evolved to favor adiposity over leanness, the availability of palatable, easily attainable, and calorically dense foods has led to unprecedented levels of obesity and its associated metabolic co-morbidities that appear resistant to traditional lifestyle interventions. However, recent progress identifying the molecular signaling pathways through which the brain and the gastrointestinal system communicate to govern energy homeostasis, combined with emerging insights on the molecular mechanisms underlying successful bariatric surgery, gives reason to be optimistic that novel precision medicines that mimic, enhance, and/or modulate gut-brain signaling can have unprecedented potential for stopping the obesity and type 2 diabetes pandemics.",

keywords = "Animals, Appetite Regulation, Brain, Energy Metabolism, Gastrointestinal Tract, Homeostasis, Humans, Neural Pathways, Pleasure, Satiation, Journal Article, Review",

author = "Christoffer Clemmensen and M{\"u}ller, {Timo D} and Woods, {Stephen C} and Hans-Rudolf Berthoud and Seeley, {Randy J} and Tsch{\"o}p, {Matthias H}",

year = "2017",

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T1 - Gut-Brain Cross-Talk in Metabolic Control

AU - Clemmensen, Christoffer

AU - Müller, Timo D

AU - Woods, Stephen C

AU - Berthoud, Hans-Rudolf

AU - Seeley, Randy J

AU - Tschöp, Matthias H

PY - 2017/2/23

Y1 - 2017/2/23

N2 - Because human energy metabolism evolved to favor adiposity over leanness, the availability of palatable, easily attainable, and calorically dense foods has led to unprecedented levels of obesity and its associated metabolic co-morbidities that appear resistant to traditional lifestyle interventions. However, recent progress identifying the molecular signaling pathways through which the brain and the gastrointestinal system communicate to govern energy homeostasis, combined with emerging insights on the molecular mechanisms underlying successful bariatric surgery, gives reason to be optimistic that novel precision medicines that mimic, enhance, and/or modulate gut-brain signaling can have unprecedented potential for stopping the obesity and type 2 diabetes pandemics.

AB - Because human energy metabolism evolved to favor adiposity over leanness, the availability of palatable, easily attainable, and calorically dense foods has led to unprecedented levels of obesity and its associated metabolic co-morbidities that appear resistant to traditional lifestyle interventions. However, recent progress identifying the molecular signaling pathways through which the brain and the gastrointestinal system communicate to govern energy homeostasis, combined with emerging insights on the molecular mechanisms underlying successful bariatric surgery, gives reason to be optimistic that novel precision medicines that mimic, enhance, and/or modulate gut-brain signaling can have unprecedented potential for stopping the obesity and type 2 diabetes pandemics.

KW - Animals

KW - Appetite Regulation

KW - Brain

KW - Energy Metabolism

KW - Gastrointestinal Tract

KW - Homeostasis

KW - Humans

KW - Neural Pathways

KW - Pleasure

KW - Satiation

KW - Journal Article

KW - Review

U2 - 10.1016/j.cell.2017.01.025

DO - 10.1016/j.cell.2017.01.025

M3 - Review

C2 - 28235194

SN - 0092-8674

VL - 168

SP - 758

EP - 774

JO - Cell

JF - Cell

IS - 5

ER -

Gut-Brain Cross-Talk in Metabolic Control

Abstract

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