Guidelines for porcine models of human bacterial infections

Louise K. Jensen; Nicole L. Henriksen; Henrik E. Jensen

doi:10.1177/0023677218789444

Guidelines for porcine models of human bacterial infections

Louise K. Jensen^*, Nicole L. Henriksen, Henrik E. Jensen

^*Corresponding author af dette arbejde

3 Citationer (Scopus)

Abstract

During the last 10 years the number of porcine models for human bacterial infectious diseases has increased. In the future, this tendency is expected to continue and, therefore, the aim of the present review is to describe guidelines for the development and reporting of these models. The guidelines are based on a review of 122 publications of porcine models for different bacterial infectious diseases in humans. The review demonstrates a substantial lack of information in most papers which hampers reproducibility and continuation of the work that was established in the models. The guidelines describe overall principles related to the inoculum, the animal, the infected animal and the post-mortem characterization that are of crucial importance when porcine models of infectious diseases are developed, validated and reported.

Originalsprog	Engelsk
Tidsskrift	Laboratory Animals
Vol/bind	53
Udgave nummer	2
Sider (fra-til)	125-136
ISSN	0023-6772
DOI	https://doi.org/10.1177/0023677218789444
Status	Udgivet - 1 apr. 2019

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10.1177/0023677218789444

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abstract = "During the last 10 years the number of porcine models for human bacterial infectious diseases has increased. In the future, this tendency is expected to continue and, therefore, the aim of the present review is to describe guidelines for the development and reporting of these models. The guidelines are based on a review of 122 publications of porcine models for different bacterial infectious diseases in humans. The review demonstrates a substantial lack of information in most papers which hampers reproducibility and continuation of the work that was established in the models. The guidelines describe overall principles related to the inoculum, the animal, the infected animal and the post-mortem characterization that are of crucial importance when porcine models of infectious diseases are developed, validated and reported.",

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author = "Jensen, {Louise K.} and Henriksen, {Nicole L.} and Jensen, {Henrik E.}",

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T1 - Guidelines for porcine models of human bacterial infections

AU - Jensen, Louise K.

AU - Henriksen, Nicole L.

AU - Jensen, Henrik E.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - During the last 10 years the number of porcine models for human bacterial infectious diseases has increased. In the future, this tendency is expected to continue and, therefore, the aim of the present review is to describe guidelines for the development and reporting of these models. The guidelines are based on a review of 122 publications of porcine models for different bacterial infectious diseases in humans. The review demonstrates a substantial lack of information in most papers which hampers reproducibility and continuation of the work that was established in the models. The guidelines describe overall principles related to the inoculum, the animal, the infected animal and the post-mortem characterization that are of crucial importance when porcine models of infectious diseases are developed, validated and reported.

AB - During the last 10 years the number of porcine models for human bacterial infectious diseases has increased. In the future, this tendency is expected to continue and, therefore, the aim of the present review is to describe guidelines for the development and reporting of these models. The guidelines are based on a review of 122 publications of porcine models for different bacterial infectious diseases in humans. The review demonstrates a substantial lack of information in most papers which hampers reproducibility and continuation of the work that was established in the models. The guidelines describe overall principles related to the inoculum, the animal, the infected animal and the post-mortem characterization that are of crucial importance when porcine models of infectious diseases are developed, validated and reported.

KW - animal models

KW - infectious diseases

KW - pigs

U2 - 10.1177/0023677218789444

DO - 10.1177/0023677218789444

M3 - Review

C2 - 30089438

AN - SCOPUS:85052593220

SN - 0023-6772

VL - 53

SP - 125

EP - 136

JO - Laboratory Animals

JF - Laboratory Animals

IS - 2

ER -

Guidelines for porcine models of human bacterial infections

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