Growth Pattern of Atherosclerotic Calcifications

Lene Lillemark Larsen, Melanie Ganz, Erik Dam, Naga Dandu, Mads Nielsen

Abstract

We present a novel method to analyze the growth of abdominal atherosclerotic plaques based on x-ray projections. The growth analysis can aid progression monitoring in clinical trials and in population screening programs. Our results are based on a longitudinal study over 8.5 years. The annotations of the calcifications are matched longitudinally using thin plate spline registration and area overlap calculations.

The growth of the calcifications is measured by the distribution of the geometry statistics of the calcifications.

The method was evaluated on 135 subjects with a total number of 611 calcifications. Our results show, for instance longitudinal growth of calcifications with a mean of 2.53 mm ($\pm$ 1.95) in the blood flow direction and correlations with pathologically related biomarkers.

OriginalsprogEngelsk
TitelCVII '08 : Second International Workshop on Computer vision for intracardiac and intravascular imaging, held in New York, USA, September 10, 2008 in conjunction with the 11th MICCAI conference
ForlagSabancí Üniversítesí. 34956 Tuzla, Istanbul
Publikationsdato2008
Sider63-70
StatusUdgivet - 2008
BegivenhedMedical Image Computing and Computer-Assisted Intervention (MICCAI), 2th Workshop on Computer Vision for Intravascular and IntraCardiac Imaging (CVII), 2008 - New York, USA
Varighed: 10 sep. 200810 sep. 2008
Konferencens nummer: 2

Konference

KonferenceMedical Image Computing and Computer-Assisted Intervention (MICCAI), 2th Workshop on Computer Vision for Intravascular and IntraCardiac Imaging (CVII), 2008
Nummer2
Land/OmrådeUSA
ByNew York
Periode10/09/200810/09/2008

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