Group I introns - moving in new directions

TY - JOUR

T1 - Group I introns - moving in new directions

AU - Nielsen, Henrik

AU - Johansen, Steinar

PY - 2009

Y1 - 2009

N2 - Group I introns are genetic elements interrupting functional genes. They are removed from precursors at the RNA level and most catalyze their own splicing. The catalytic part of these constitutes one of the major classes of catalytic RNAs, the group I ribozymes. However, group I introns have a lot more to offer than their own elimination by splicing. Intron RNA can circularize in at least three different ways and introns are mobile both at the DNA and RNA level. Some group I introns have a very complex organization incorporating functional genes and other sequence elements and have established deep relationships with their host genomes. Finally, group I introns can develop into new ribozymes with new biological functions

AB - Group I introns are genetic elements interrupting functional genes. They are removed from precursors at the RNA level and most catalyze their own splicing. The catalytic part of these constitutes one of the major classes of catalytic RNAs, the group I ribozymes. However, group I introns have a lot more to offer than their own elimination by splicing. Intron RNA can circularize in at least three different ways and introns are mobile both at the DNA and RNA level. Some group I introns have a very complex organization incorporating functional genes and other sequence elements and have established deep relationships with their host genomes. Finally, group I introns can develop into new ribozymes with new biological functions

M3 - Journal article

SN - 1547-6286

VL - 6

SP - 375

EP - 383

JO - RNA Biology

JF - RNA Biology

IS - 4

ER -