Glycan-mediated modification of the immune response

TY - JOUR

T1 - Glycan-mediated modification of the immune response

AU - Madsen, Caroline B

AU - Pedersen, Anders E

AU - Wandall, Hans H

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Aberrantly glycosylated tumor antigens represent promising targets for the development of anti-cancer vaccines, yet how glycans influence immune responses is poorly understood. Recent studies have demonstrated that GalNAc-glycosylation enhances antigen uptake by dendritic cells as well as CD4(+) T-cell and humoral responses, but prevents CD8(+) T-cell activation. Here, we briefly discuss the relevance of glycans as candidate targets for anti-cancer vaccines.

AB - Aberrantly glycosylated tumor antigens represent promising targets for the development of anti-cancer vaccines, yet how glycans influence immune responses is poorly understood. Recent studies have demonstrated that GalNAc-glycosylation enhances antigen uptake by dendritic cells as well as CD4(+) T-cell and humoral responses, but prevents CD8(+) T-cell activation. Here, we briefly discuss the relevance of glycans as candidate targets for anti-cancer vaccines.

U2 - 10.4161/onci.23659

DO - 10.4161/onci.23659

M3 - Journal article

C2 - 23734320

SN - 2162-4011

VL - 2

SP - e23659

JO - OncoImmunology

JF - OncoImmunology

IS - 4

ER -