Glutamate receptors: variation in structure-function coupling

Anders Skov Kristensen; Matthew Geballe; James P Snyder; Stephen F Traynelis

Glutamate receptors: variation in structure-function coupling

Anders Skov Kristensen, Matthew Geballe, James P Snyder, Stephen F Traynelis

5 Citationer (Scopus)

Abstract

Fast excitatory synaptic transmission in the CNS relies almost entirely on the neurotransmitter glutamate and its family of ion channel receptors. An appreciation of the coupling between agonist binding and channel opening has advanced rapidly during the past five years, largely as a result of new structural information about the agonist-binding site. Recent studies suggest that despite many structural similarities different family members use different mechanisms to translate agonist binding into channel opening.

Originalsprog	Engelsk
Tidsskrift	Trends in Pharmacological Sciences
Vol/bind	27
Udgave nummer	2
Sider (fra-til)	65-69
Antal sider	5
ISSN	0165-6147
Status	Udgivet - feb. 2006

Citationsformater

@article{67b4b3d732754bf5848aa812aed626e1,

title = "Glutamate receptors: variation in structure-function coupling",

abstract = "Fast excitatory synaptic transmission in the CNS relies almost entirely on the neurotransmitter glutamate and its family of ion channel receptors. An appreciation of the coupling between agonist binding and channel opening has advanced rapidly during the past five years, largely as a result of new structural information about the agonist-binding site. Recent studies suggest that despite many structural similarities different family members use different mechanisms to translate agonist binding into channel opening.",

author = "Kristensen, {Anders Skov} and Matthew Geballe and Snyder, {James P} and Traynelis, {Stephen F}",

year = "2006",

month = feb,

language = "English",

volume = "27",

pages = "65--69",

journal = "Trends in Pharmacological Sciences",

issn = "0165-6147",

publisher = "Elsevier Ltd. * Trends Journals",

number = "2",

}

TY - JOUR

T1 - Glutamate receptors: variation in structure-function coupling

AU - Kristensen, Anders Skov

AU - Geballe, Matthew

AU - Snyder, James P

AU - Traynelis, Stephen F

PY - 2006/2

Y1 - 2006/2

N2 - Fast excitatory synaptic transmission in the CNS relies almost entirely on the neurotransmitter glutamate and its family of ion channel receptors. An appreciation of the coupling between agonist binding and channel opening has advanced rapidly during the past five years, largely as a result of new structural information about the agonist-binding site. Recent studies suggest that despite many structural similarities different family members use different mechanisms to translate agonist binding into channel opening.

AB - Fast excitatory synaptic transmission in the CNS relies almost entirely on the neurotransmitter glutamate and its family of ion channel receptors. An appreciation of the coupling between agonist binding and channel opening has advanced rapidly during the past five years, largely as a result of new structural information about the agonist-binding site. Recent studies suggest that despite many structural similarities different family members use different mechanisms to translate agonist binding into channel opening.

M3 - Journal article

SN - 0165-6147

VL - 27

SP - 65

EP - 69

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 2

ER -