Glucose ingestion during endurance training in men attenuates expression of myokine receptor

TY - JOUR

T1 - Glucose ingestion during endurance training in men attenuates expression of myokine receptor

AU - Åkerström, Thorbjörn

AU - Krogh-Madsen, Rikke

AU - Petersen, Anne Marie Winther

AU - Pedersen, Bente Klarlund

N1 - Keywords: Adaptation, Physiological; Adult; Bicycling; Blotting, Western; Glucose; Humans; Interleukin-6; Interleukin-6 Receptor alpha Subunit; Male; Muscle, Skeletal; Physical Endurance; Physical Fitness; RNA, Messenger; Reverse Transcriptase Polymerase Chain Reaction; Young Adult

PY - 2009

Y1 - 2009

N2 - Glucose ingestion during exercise attenuates the release of the myokine interleukin-6 (IL-6) from working skeletal muscle, which results in a diminished increase in plasma IL-6. Interleukin-6 receptor alpha (IL-6Ralpha) expression in skeletal muscle is induced by acute exercise, mediated in part by an increased IL-6 concentration in the bloodstream. We hypothesized that endurance training would increase the density of IL-6Ralpha in skeletal muscle and that glucose ingestion would attenuate the effect. Nine subjects performed 10 weeks of one-legged knee-extensor training. They trained one leg (Glc-leg) while ingesting a glucose solution (Glc) and ingested a placebo (Plc) while training the other leg (Plc-leg). Endurance training increased peak power by 14% and reduced the exercise-induced gene expression of IL-6 and IL-6Ralpha in skeletal muscle and IL-6 plasma concentration. The IL-6Ralpha density increased to a lesser extent in the Glc-leg, suggesting that glucose ingestion attenuates the effect of training on IL-6Ralpha by blunting the IL-6 response. We conclude that glucose ingestion during endurance training attenuates the increase in IL-6Ralpha density.

AB - Glucose ingestion during exercise attenuates the release of the myokine interleukin-6 (IL-6) from working skeletal muscle, which results in a diminished increase in plasma IL-6. Interleukin-6 receptor alpha (IL-6Ralpha) expression in skeletal muscle is induced by acute exercise, mediated in part by an increased IL-6 concentration in the bloodstream. We hypothesized that endurance training would increase the density of IL-6Ralpha in skeletal muscle and that glucose ingestion would attenuate the effect. Nine subjects performed 10 weeks of one-legged knee-extensor training. They trained one leg (Glc-leg) while ingesting a glucose solution (Glc) and ingested a placebo (Plc) while training the other leg (Plc-leg). Endurance training increased peak power by 14% and reduced the exercise-induced gene expression of IL-6 and IL-6Ralpha in skeletal muscle and IL-6 plasma concentration. The IL-6Ralpha density increased to a lesser extent in the Glc-leg, suggesting that glucose ingestion attenuates the effect of training on IL-6Ralpha by blunting the IL-6 response. We conclude that glucose ingestion during endurance training attenuates the increase in IL-6Ralpha density.

U2 - 10.1113/expphysiol.2009.048983

DO - 10.1113/expphysiol.2009.048983

M3 - Journal article

C2 - 19592412

SN - 0958-0670

VL - 94

SP - 1124

EP - 1131

JO - Experimental Physiology

JF - Experimental Physiology

IS - 11

ER -