Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes

TY - JOUR

T1 - Glucagon-like Peptide-1 and the Central/Peripheral Nervous System

T2 - Crosstalk in Diabetes

AU - Muscogiuri, Giovanna

AU - DeFronzo, Ralph A

AU - Gastaldelli, Amalia

AU - Holst, Jens J

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Glucagon-like peptide-1 (GLP-1) is released in response to meals and exerts important roles in the maintenance of normal glucose homeostasis. GLP-1 is also important in the regulation of neurologic and cognitive functions. These actions are mediated via neurons in the nucleus of the solitary tract that project to multiple regions expressing GLP-1 receptors (GLP-1Rs). Treatment with GLP-1R agonists (GLP-1-RAs) reduces ischemia-induced hyperactivity, oxidative stress, neuronal damage and apoptosis, cerebral infarct volume, and neurologic damage, after cerebral ischemia, in experimental models. Ongoing human trials report a neuroprotective effect of GLP-1-RAs in Alzheimer's and Parkinson's disease. In this review, we discuss the role of GLP-1 and GLP-1-RAs in the nervous system with focus on GLP-1 actions on appetite regulation, glucose homeostasis, and neuroprotection.

AB - Glucagon-like peptide-1 (GLP-1) is released in response to meals and exerts important roles in the maintenance of normal glucose homeostasis. GLP-1 is also important in the regulation of neurologic and cognitive functions. These actions are mediated via neurons in the nucleus of the solitary tract that project to multiple regions expressing GLP-1 receptors (GLP-1Rs). Treatment with GLP-1R agonists (GLP-1-RAs) reduces ischemia-induced hyperactivity, oxidative stress, neuronal damage and apoptosis, cerebral infarct volume, and neurologic damage, after cerebral ischemia, in experimental models. Ongoing human trials report a neuroprotective effect of GLP-1-RAs in Alzheimer's and Parkinson's disease. In this review, we discuss the role of GLP-1 and GLP-1-RAs in the nervous system with focus on GLP-1 actions on appetite regulation, glucose homeostasis, and neuroprotection.

U2 - 10.1016/j.tem.2016.10.001

DO - 10.1016/j.tem.2016.10.001

M3 - Review

C2 - 27871675

SN - 1043-2760

VL - 28

SP - 88

EP - 103

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 2

ER -