Glomerular Filtration Rate Estimation in Renal and Non-Renal Solid Organ Transplantation

Mads Hornum; Bo Feldt-Rasmussen

doi:10.1159/000447673

Glomerular Filtration Rate Estimation in Renal and Non-Renal Solid Organ Transplantation

Mads Hornum, Bo Feldt-Rasmussen

Institut for Klinisk Medicin

2 Citationer (Scopus)

7 Downloads (Pure)

Abstract

Following transplantation (TX) of both renal and non-renal organs, a large proportion of patients have renal dysfunction. There are multiple causes for this. Chronic nephrotoxicity and high doses of calcineurin inhibitors are important factors. Preoperative and perioperative factors like hypertension, hypotension, drugs and infections may play a causative role as well. Organ-specific causes include hepatorenal syndrome, cirrhosis, low cardiac function, low respiratory function and diabetes developed both before and after TX. It is important to be able to perform precise and valid measurements or estimates of renal function in these patients, in order to accurately and safely dose immunosuppressive medication and perform and adjust the treatment and prophylaxis of renal dysfunction. This is a short overview and discussion of relevant studies and possible caveats of estimated glomerular filtration rate methods for use in renal and non-renal TX.

Originalsprog	Engelsk
Tidsskrift	Nephron
Vol/bind	136
Udgave nummer	4
Sider (fra-til)	298-301
ISSN	1660-8151
DOI	https://doi.org/10.1159/000447673
Status	Udgivet - 1 jul. 2017

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title = "Glomerular Filtration Rate Estimation in Renal and Non-Renal Solid Organ Transplantation",

abstract = "Following transplantation (TX) of both renal and non-renal organs, a large proportion of patients have renal dysfunction. There are multiple causes for this. Chronic nephrotoxicity and high doses of calcineurin inhibitors are important factors. Preoperative and perioperative factors like hypertension, hypotension, drugs and infections may play a causative role as well. Organ-specific causes include hepatorenal syndrome, cirrhosis, low cardiac function, low respiratory function and diabetes developed both before and after TX. It is important to be able to perform precise and valid measurements or estimates of renal function in these patients, in order to accurately and safely dose immunosuppressive medication and perform and adjust the treatment and prophylaxis of renal dysfunction. This is a short overview and discussion of relevant studies and possible caveats of estimated glomerular filtration rate methods for use in renal and non-renal TX.",

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author = "Mads Hornum and Bo Feldt-Rasmussen",

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T1 - Glomerular Filtration Rate Estimation in Renal and Non-Renal Solid Organ Transplantation

AU - Hornum, Mads

AU - Feldt-Rasmussen, Bo

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N2 - Following transplantation (TX) of both renal and non-renal organs, a large proportion of patients have renal dysfunction. There are multiple causes for this. Chronic nephrotoxicity and high doses of calcineurin inhibitors are important factors. Preoperative and perioperative factors like hypertension, hypotension, drugs and infections may play a causative role as well. Organ-specific causes include hepatorenal syndrome, cirrhosis, low cardiac function, low respiratory function and diabetes developed both before and after TX. It is important to be able to perform precise and valid measurements or estimates of renal function in these patients, in order to accurately and safely dose immunosuppressive medication and perform and adjust the treatment and prophylaxis of renal dysfunction. This is a short overview and discussion of relevant studies and possible caveats of estimated glomerular filtration rate methods for use in renal and non-renal TX.

AB - Following transplantation (TX) of both renal and non-renal organs, a large proportion of patients have renal dysfunction. There are multiple causes for this. Chronic nephrotoxicity and high doses of calcineurin inhibitors are important factors. Preoperative and perioperative factors like hypertension, hypotension, drugs and infections may play a causative role as well. Organ-specific causes include hepatorenal syndrome, cirrhosis, low cardiac function, low respiratory function and diabetes developed both before and after TX. It is important to be able to perform precise and valid measurements or estimates of renal function in these patients, in order to accurately and safely dose immunosuppressive medication and perform and adjust the treatment and prophylaxis of renal dysfunction. This is a short overview and discussion of relevant studies and possible caveats of estimated glomerular filtration rate methods for use in renal and non-renal TX.

KW - Journal Article

U2 - 10.1159/000447673

DO - 10.1159/000447673

M3 - Review

C2 - 27388425

SN - 1660-8151

VL - 136

SP - 298

EP - 301

JO - Nephron

JF - Nephron

IS - 4

ER -

Glomerular Filtration Rate Estimation in Renal and Non-Renal Solid Organ Transplantation

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