GH administration and discontinuation in healthy elderly men: effects on body composition, GH-related serum markers, resting heart rate and resting oxygen uptake

K H Lange; F Isaksson; M H Rasmussen; A Juul; J Bülow; M Kjaer

GH administration and discontinuation in healthy elderly men: effects on body composition, GH-related serum markers, resting heart rate and resting oxygen uptake

K H Lange, F Isaksson, M H Rasmussen, A Juul, J Bülow, M Kjaer

Institut for Klinisk Medicin

30 Citationer (Scopus)

Abstract

GH administration results in increased lean body mass (LBM), decreased fat mass (FM) and increased energy expenditure (EE). GH therapy may therefore have potential benefits, especially in the elderly, who are known to have decreased function of the GH/IGF-I axis. Several studies have focused on effects of GH administration in the elderly in the last decade. However, very limited information is available regarding changes in body composition and EE upon GH discontinuation in the elderly. The present study therefore investigated the effects of 12 weeks of GH administration and subsequent discontinuation on body composition, resting oxygen uptake (VO2), resting heart rate (HR) and GH related serum markers in healthy elderly men.

Originalsprog	Engelsk
Tidsskrift	Clinical Endocrinology
Vol/bind	55
Udgave nummer	1
Sider (fra-til)	77-86
Antal sider	10
ISSN	0300-0664
Status	Udgivet - 2001

Citationsformater

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title = "GH administration and discontinuation in healthy elderly men: effects on body composition, GH-related serum markers, resting heart rate and resting oxygen uptake",

abstract = "GH administration results in increased lean body mass (LBM), decreased fat mass (FM) and increased energy expenditure (EE). GH therapy may therefore have potential benefits, especially in the elderly, who are known to have decreased function of the GH/IGF-I axis. Several studies have focused on effects of GH administration in the elderly in the last decade. However, very limited information is available regarding changes in body composition and EE upon GH discontinuation in the elderly. The present study therefore investigated the effects of 12 weeks of GH administration and subsequent discontinuation on body composition, resting oxygen uptake (VO2), resting heart rate (HR) and GH related serum markers in healthy elderly men.",

author = "Lange, {K H} and F Isaksson and Rasmussen, {M H} and A Juul and J B{\"u}low and M Kjaer",

year = "2001",

language = "English",

volume = "55",

pages = "77--86",

journal = "Clinical Endocrinology",

issn = "0300-0664",

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TY - JOUR

T1 - GH administration and discontinuation in healthy elderly men

T2 - effects on body composition, GH-related serum markers, resting heart rate and resting oxygen uptake

AU - Lange, K H

AU - Isaksson, F

AU - Rasmussen, M H

AU - Juul, A

AU - Bülow, J

AU - Kjaer, M

PY - 2001

Y1 - 2001

N2 - GH administration results in increased lean body mass (LBM), decreased fat mass (FM) and increased energy expenditure (EE). GH therapy may therefore have potential benefits, especially in the elderly, who are known to have decreased function of the GH/IGF-I axis. Several studies have focused on effects of GH administration in the elderly in the last decade. However, very limited information is available regarding changes in body composition and EE upon GH discontinuation in the elderly. The present study therefore investigated the effects of 12 weeks of GH administration and subsequent discontinuation on body composition, resting oxygen uptake (VO2), resting heart rate (HR) and GH related serum markers in healthy elderly men.

AB - GH administration results in increased lean body mass (LBM), decreased fat mass (FM) and increased energy expenditure (EE). GH therapy may therefore have potential benefits, especially in the elderly, who are known to have decreased function of the GH/IGF-I axis. Several studies have focused on effects of GH administration in the elderly in the last decade. However, very limited information is available regarding changes in body composition and EE upon GH discontinuation in the elderly. The present study therefore investigated the effects of 12 weeks of GH administration and subsequent discontinuation on body composition, resting oxygen uptake (VO2), resting heart rate (HR) and GH related serum markers in healthy elderly men.

M3 - Journal article

SN - 0300-0664

VL - 55

SP - 77

EP - 86

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 1

ER -

GH administration and discontinuation in healthy elderly men: effects on body composition, GH-related serum markers, resting heart rate and resting oxygen uptake

Abstract

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Citationsformater