Geographical distribution and surveillance of Crimean-Congo hemorrhagic fever in Iran

TY - JOUR

T1 - Geographical distribution and surveillance of Crimean-Congo hemorrhagic fever in Iran

AU - Chinikar, Sadegh

AU - Ghiasi, Seyed Mojtaba

AU - Moradi, Maryam

AU - Goya, Mohammd M

AU - Shirzadi, Mohammd R

AU - Zeinali, Mohammd

AU - Meshkat, Mohsen

AU - Bouloy, Michele

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Crimean-Congo hemorrhagic fever (CCHF) is viral hemorrhagic fever caused by CCHF virus, which belongs to the family Bunyaviridae and the genus Nairovirus. The virus is transmitted to humans via contact with blood and tissue from infected livestock, a tick bite, or contact with an infected person. Since 2000, we have shown the disease to be prevalent in 23 out of 30 provinces of Iran. Among those, Sistan-va-Baluchistan, Isfahan, Fars, Tehran, Khorasan, and Khuzestan demonstrated the highest infection, respectively. Notably, Sistan-va-Baluchistan province, southeast of Iran, has the highest prevalence of CCHF, and has shown to be present since at least 2000. Phylogenetic study of the CCHF virus genome isolated from Iranian patients showed a close relationship with the CCHF Matin strain (Pakistan). Our epidemiological data in the last decade have implied that the severity and fatality rate of the disease has ranged variably in different provinces of Iran. More pathogenesis and phylogenetic studies should therefore be investigated to clarify these differences.

AB - Crimean-Congo hemorrhagic fever (CCHF) is viral hemorrhagic fever caused by CCHF virus, which belongs to the family Bunyaviridae and the genus Nairovirus. The virus is transmitted to humans via contact with blood and tissue from infected livestock, a tick bite, or contact with an infected person. Since 2000, we have shown the disease to be prevalent in 23 out of 30 provinces of Iran. Among those, Sistan-va-Baluchistan, Isfahan, Fars, Tehran, Khorasan, and Khuzestan demonstrated the highest infection, respectively. Notably, Sistan-va-Baluchistan province, southeast of Iran, has the highest prevalence of CCHF, and has shown to be present since at least 2000. Phylogenetic study of the CCHF virus genome isolated from Iranian patients showed a close relationship with the CCHF Matin strain (Pakistan). Our epidemiological data in the last decade have implied that the severity and fatality rate of the disease has ranged variably in different provinces of Iran. More pathogenesis and phylogenetic studies should therefore be investigated to clarify these differences.

KW - Adult

KW - Female

KW - Hemorrhagic Fever, Crimean

KW - Humans

KW - Iran

KW - Male

KW - Time Factors

KW - Young Adult

U2 - 10.1089/vbz.2009.0247

DO - 10.1089/vbz.2009.0247

M3 - Journal article

C2 - 20854025

SN - 1530-3667

VL - 10

SP - 705

EP - 708

JO - Vector Borne and Zoonotic Diseases

JF - Vector Borne and Zoonotic Diseases

IS - 7

ER -