Genomet og diabetes

Kristine Højgaard Allin; Torben Hansen; Oluf Borbye Pedersen

Genomet og diabetes

Kristine Højgaard Allin, Torben Hansen, Oluf Borbye Pedersen

Abstract

In terms of their genetic architecture monogenic diabetes and type 2 diabetes represent two extremes. Whereas each subtype of monogenic diabetes is caused by one penetrant, rare mutation in a single gene, the genetic susceptibility to type 2 diabetes can be attributed to many low-penetrant variants across the genome. At present, only 10% of the genetic susceptibility to type 2 diabetes can be explained by the hitherto identified 90 genomic loci. Here we briefly review the genetics of monogenic diabetes and type 2 diabetes and outline future directions of research within this field.

Originalsprog	Dansk
Artikelnummer	V06140337
Tidsskrift	Ugeskrift for Laeger
Vol/bind	176
Udgave nummer	23
Sider (fra-til)	2176-2179
ISSN	0041-5782
Status	Udgivet - 10 nov. 2014

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Adgang til dokumentet

http://ugeskriftet.dk/videnskab/genomet-og-diabetes

Citationsformater

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