Genomes of early onset prostate cancer

Joachim Weischenfeldt; Jan O. Korbel

doi:10.1097/MOU.0000000000000422

Genomes of early onset prostate cancer

Joachim Weischenfeldt^*, Jan O. Korbel

^*Corresponding author af dette arbejde

6 Citationer (Scopus)

Abstract

Purpose of review Prostate cancer is a disease of the elderly but a clinically relevant subset occurs early in life. In the current review, we discuss recent findings and the current understanding of the molecular underpinnings associated with early-onset prostate cancer (PCa) and the evidence supporting age-specific differences in the cancer genomes. Recent findings Recent surveys of PCa patient cohorts have provided novel age-dependent links between germline and somatic aberrations which points to differences in the molecular cause and treatment options. Summary Identifying the earliest molecular alterations in PCa can provide insight into the cause of the disease and biomarkers for patient risk stratification. Genomic aberrations of early-onset PCas display several patterns distinct from late-onset PCa genomes, suggesting age-dependent pathomechanisms involving alterations in the androgen receptor pathway.

Originalsprog	Engelsk
Tidsskrift	Current Opinion in Urology
Vol/bind	27
Udgave nummer	5
Sider (fra-til)	481-487
Antal sider	7
ISSN	0963-0643
DOI	https://doi.org/10.1097/MOU.0000000000000422
Status	Udgivet - 1 sep. 2017

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10.1097/MOU.0000000000000422

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title = "Genomes of early onset prostate cancer",

abstract = "Purpose of review Prostate cancer is a disease of the elderly but a clinically relevant subset occurs early in life. In the current review, we discuss recent findings and the current understanding of the molecular underpinnings associated with early-onset prostate cancer (PCa) and the evidence supporting age-specific differences in the cancer genomes. Recent findings Recent surveys of PCa patient cohorts have provided novel age-dependent links between germline and somatic aberrations which points to differences in the molecular cause and treatment options. Summary Identifying the earliest molecular alterations in PCa can provide insight into the cause of the disease and biomarkers for patient risk stratification. Genomic aberrations of early-onset PCas display several patterns distinct from late-onset PCa genomes, suggesting age-dependent pathomechanisms involving alterations in the androgen receptor pathway.",

keywords = "androgen receptor, early-onset prostate cancer, ERG fusion gene, genomic structural rearrangements",

author = "Joachim Weischenfeldt and Korbel, {Jan O.}",

year = "2017",

month = sep,

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doi = "10.1097/MOU.0000000000000422",

language = "English",

volume = "27",

pages = "481--487",

journal = "Current Opinion in Urology",

issn = "0963-0643",

publisher = "Lippincott Williams & Wilkins, Ltd.",

number = "5",

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TY - JOUR

T1 - Genomes of early onset prostate cancer

AU - Weischenfeldt, Joachim

AU - Korbel, Jan O.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Purpose of review Prostate cancer is a disease of the elderly but a clinically relevant subset occurs early in life. In the current review, we discuss recent findings and the current understanding of the molecular underpinnings associated with early-onset prostate cancer (PCa) and the evidence supporting age-specific differences in the cancer genomes. Recent findings Recent surveys of PCa patient cohorts have provided novel age-dependent links between germline and somatic aberrations which points to differences in the molecular cause and treatment options. Summary Identifying the earliest molecular alterations in PCa can provide insight into the cause of the disease and biomarkers for patient risk stratification. Genomic aberrations of early-onset PCas display several patterns distinct from late-onset PCa genomes, suggesting age-dependent pathomechanisms involving alterations in the androgen receptor pathway.

AB - Purpose of review Prostate cancer is a disease of the elderly but a clinically relevant subset occurs early in life. In the current review, we discuss recent findings and the current understanding of the molecular underpinnings associated with early-onset prostate cancer (PCa) and the evidence supporting age-specific differences in the cancer genomes. Recent findings Recent surveys of PCa patient cohorts have provided novel age-dependent links between germline and somatic aberrations which points to differences in the molecular cause and treatment options. Summary Identifying the earliest molecular alterations in PCa can provide insight into the cause of the disease and biomarkers for patient risk stratification. Genomic aberrations of early-onset PCas display several patterns distinct from late-onset PCa genomes, suggesting age-dependent pathomechanisms involving alterations in the androgen receptor pathway.

KW - androgen receptor

KW - early-onset prostate cancer

KW - ERG fusion gene

KW - genomic structural rearrangements

U2 - 10.1097/MOU.0000000000000422

DO - 10.1097/MOU.0000000000000422

M3 - Review

C2 - 28661899

AN - SCOPUS:85021626539

SN - 0963-0643

VL - 27

SP - 481

EP - 487

JO - Current Opinion in Urology

JF - Current Opinion in Urology

IS - 5

ER -

Genomes of early onset prostate cancer

Abstract

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