Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

Beatrice S Melin; Jill S Barnholtz-Sloan; Margaret R. Wrensch; Christoffer Johansen; Dora Il'yasova; Ben Kinnersley; Quinn T Ostrom; Karim Labreche; Yanwen Chen; Georgina N Armstrong; Yanhong Liu; Jeanette Eckel-Passow; Paul A Decker; Marianne Labussière; Ahmed Idbaih; Khe Hoang-Xuan; Anna-Luisa Di Stefano; Karima Mokhtari; Jean-Yves Delattre; Peter Broderick; Pilar Galan; Konstantinos Gousias; Johannes Schramm; Minouk J Schoemaker; Sarah J Fleming; Stefan Herms; Stefanie Heilmann-Heimbach; Markus M Nöthen; Heinz-Erich Wichmann; Stefan Schreiber; Anthony Swerdlow; Mark Lathrop; Matthias Simon; Marc Sanson; Ulrika Andersson; Preetha Rajaraman; Stephen Chanock; Martha S Linet; Zhaoming Wang; Meredith Yeager; GliomaScan Consortium; John K Wiencke; Helen Hansen; Lucie S. Mccoy; Terri Rice; Matthew L Kosel; Hugues Sicotte; Christopher I Amos; Jonine L Bernstein; Faith G Davis; Dan Lachance

doi:10.1038/ng.3823

Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

Beatrice S Melin, Jill S Barnholtz-Sloan, Margaret R. Wrensch, Christoffer Johansen, Dora Il'yasova, Ben Kinnersley, Quinn T Ostrom, Karim Labreche, Yanwen Chen, Georgina N Armstrong, Yanhong Liu, Jeanette Eckel-Passow, Paul A Decker, Marianne Labussière, Ahmed Idbaih, Khe Hoang-Xuan, Anna-Luisa Di Stefano, Karima Mokhtari, Jean-Yves Delattre, Peter BroderickPilar Galan, Konstantinos Gousias, Johannes Schramm, Minouk J Schoemaker, Sarah J Fleming, Stefan Herms, Stefanie Heilmann-Heimbach, Markus M Nöthen, Heinz-Erich Wichmann, Stefan Schreiber, Anthony Swerdlow, Mark Lathrop, Matthias Simon, Marc Sanson, Ulrika Andersson, Preetha Rajaraman, Stephen Chanock, Martha S Linet, Zhaoming Wang, Meredith Yeager, GliomaScan Consortium, John K Wiencke, Helen Hansen, Lucie S. Mccoy, Terri Rice, Matthew L Kosel, Hugues Sicotte, Christopher I Amos, Jonine L Bernstein, Faith G Davis, Dan Lachance

Institut for Klinisk Medicin

115 Citationer (Scopus)

Abstract

Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10(-8), OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10(-8), OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.

Originalsprog	Engelsk
Tidsskrift	Nature Genetics
Vol/bind	49
Udgave nummer	5
Sider (fra-til)	789-794
Antal sider	6
ISSN	1061-4036
DOI	https://doi.org/10.1038/ng.3823
Status	Udgivet - 1 maj 2017

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10.1038/ng.3823

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Melin, B. S., Barnholtz-Sloan, J. S., Wrensch, M. R., Johansen, C., Il'yasova, D., Kinnersley, B., Ostrom, Q. T., Labreche, K., Chen, Y., Armstrong, G. N., Liu, Y., Eckel-Passow, J., Decker, P. A., Labussière, M., Idbaih, A., Hoang-Xuan, K., Di Stefano, A-L., Mokhtari, K., Delattre, J-Y., ... Lachance, D. (2017). Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. Nature Genetics, 49(5), 789-794. https://doi.org/10.1038/ng.3823

Melin, BS, Barnholtz-Sloan, JS, Wrensch, MR, Johansen, C, Il'yasova, D, Kinnersley, B, Ostrom, QT, Labreche, K, Chen, Y, Armstrong, GN, Liu, Y, Eckel-Passow, J, Decker, PA, Labussière, M, Idbaih, A, Hoang-Xuan, K, Di Stefano, A-L, Mokhtari, K, Delattre, J-Y, Broderick, P, Galan, P, Gousias, K, Schramm, J, Schoemaker, MJ, Fleming, SJ, Herms, S, Heilmann-Heimbach, S, Nöthen, MM, Wichmann, H-E, Schreiber, S, Swerdlow, A, Lathrop, M, Simon, M, Sanson, M, Andersson, U, Rajaraman, P, Chanock, S, Linet, MS, Wang, Z, Yeager, M, GliomaScan Consortium, Wiencke, JK, Hansen, H, Mccoy, LS, Rice, T, Kosel, ML, Sicotte, H, Amos, CI, Bernstein, JL, Davis, FG & Lachance, D 2017, 'Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors', Nature Genetics, bind 49, nr. 5, s. 789-794. https://doi.org/10.1038/ng.3823

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title = "Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors",

abstract = "Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10(-8), OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10(-8), OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.",

keywords = "Journal Article",

author = "Melin, {Beatrice S} and Barnholtz-Sloan, {Jill S} and Wrensch, {Margaret R.} and Christoffer Johansen and Dora Il'yasova and Ben Kinnersley and Ostrom, {Quinn T} and Karim Labreche and Yanwen Chen and Armstrong, {Georgina N} and Yanhong Liu and Jeanette Eckel-Passow and Decker, {Paul A} and Marianne Labussi{\`e}re and Ahmed Idbaih and Khe Hoang-Xuan and {Di Stefano}, Anna-Luisa and Karima Mokhtari and Jean-Yves Delattre and Peter Broderick and Pilar Galan and Konstantinos Gousias and Johannes Schramm and Schoemaker, {Minouk J} and Fleming, {Sarah J} and Stefan Herms and Stefanie Heilmann-Heimbach and N{\"o}then, {Markus M} and Heinz-Erich Wichmann and Stefan Schreiber and Anthony Swerdlow and Mark Lathrop and Matthias Simon and Marc Sanson and Ulrika Andersson and Preetha Rajaraman and Stephen Chanock and Linet, {Martha S} and Zhaoming Wang and Meredith Yeager and {GliomaScan Consortium} and Wiencke, {John K} and Helen Hansen and Mccoy, {Lucie S.} and Terri Rice and Kosel, {Matthew L} and Hugues Sicotte and Amos, {Christopher I} and Bernstein, {Jonine L} and Davis, {Faith G} and Dan Lachance",

year = "2017",

month = may,

day = "1",

doi = "10.1038/ng.3823",

language = "English",

volume = "49",

pages = "789--794",

journal = "Nature: New biology",

issn = "1061-4036",

publisher = "nature publishing group",

number = "5",

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TY - JOUR

T1 - Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

AU - Melin, Beatrice S

AU - Barnholtz-Sloan, Jill S

AU - Wrensch, Margaret R.

AU - Johansen, Christoffer

AU - Il'yasova, Dora

AU - Kinnersley, Ben

AU - Ostrom, Quinn T

AU - Labreche, Karim

AU - Chen, Yanwen

AU - Armstrong, Georgina N

AU - Liu, Yanhong

AU - Eckel-Passow, Jeanette

AU - Decker, Paul A

AU - Labussière, Marianne

AU - Idbaih, Ahmed

AU - Hoang-Xuan, Khe

AU - Di Stefano, Anna-Luisa

AU - Mokhtari, Karima

AU - Delattre, Jean-Yves

AU - Broderick, Peter

AU - Galan, Pilar

AU - Gousias, Konstantinos

AU - Schramm, Johannes

AU - Schoemaker, Minouk J

AU - Fleming, Sarah J

AU - Herms, Stefan

AU - Heilmann-Heimbach, Stefanie

AU - Nöthen, Markus M

AU - Wichmann, Heinz-Erich

AU - Schreiber, Stefan

AU - Swerdlow, Anthony

AU - Lathrop, Mark

AU - Simon, Matthias

AU - Sanson, Marc

AU - Andersson, Ulrika

AU - Rajaraman, Preetha

AU - Chanock, Stephen

AU - Linet, Martha S

AU - Wang, Zhaoming

AU - Yeager, Meredith

AU - GliomaScan Consortium

AU - Wiencke, John K

AU - Hansen, Helen

AU - Mccoy, Lucie S.

AU - Rice, Terri

AU - Kosel, Matthew L

AU - Sicotte, Hugues

AU - Amos, Christopher I

AU - Bernstein, Jonine L

AU - Davis, Faith G

AU - Lachance, Dan

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10(-8), OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10(-8), OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.

AB - Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10(-8), OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10(-8), OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.

KW - Journal Article

U2 - 10.1038/ng.3823

DO - 10.1038/ng.3823

M3 - Letter

C2 - 28346443

SN - 1061-4036

VL - 49

SP - 789

EP - 794

JO - Nature: New biology

JF - Nature: New biology

IS - 5

ER -

Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

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