Genetic variation in ABCA1 predicts ischemic heart disease in the general population

Ruth Frikke-Schmidt; BG Nordestgaard; Gorm B Jensen; R Steffensen; A Tybjaerg-Hansen; Børge G Nordestgaard; Anne Tybjaerg-Hansen; Ruth Frikke-Schmidt; Rolf Steffensen

doi:10.1161/ATVBAHA.107.153858

Genetic variation in ABCA1 predicts ischemic heart disease in the general population

Ruth Frikke-Schmidt, BG Nordestgaard, Gorm B Jensen, R Steffensen, A Tybjaerg-Hansen, Børge G Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt, Rolf Steffensen

109 Citationer (Scopus)

Abstract

Objective - We tested the hypothesis that 6 nonsynonymous single nucleotide polymorphisms ( SNPs) in ATP-Binding-Cassette transporter A1 (ABCA1) affect risk of ischemic heart disease (IHD) in the general population. Methods and Results - We genotyped 9259 individuals from the Danish general population followed for 25 years. Two SNPs (V771M and V825I) were previously associated with increases in HDL-C, 1 (R1587K) with decreased HDL-C, whereas 3 (R219K, I883M and E1172D) did not affect HDL-C levels. Despite this, 5 out of 6 SNPs ( V771M, V825I, I883M, E1172D, R1587K) predicted increased risk of IHD. Similar results were obtained in a verification sample with 932 IHD cases versus 7999 controls. A stepwise regression approach identified V771M, I883M, and E1172D as the most important predictors of IHD and additive effects on IHD risk were present for V771M/I883M and I883M/E1172D pairs. Conclusions - We show that 3 of 6 nonsynonymous SNPs in ABCA1 predict risk of IHD in the general population
Udgivelsesdato: 2008/1/1

Originalsprog	Engelsk
Tidsskrift	Arteriosclerosis, Thrombosis, and Vascular Biology
Vol/bind	28
Udgave nummer	1
Sider (fra-til)	180-6
Antal sider	7
ISSN	1079-5642
DOI	https://doi.org/10.1161/ATVBAHA.107.153858 https://doi.org/10.1161/ATVBAHA.107.153858
Status	Udgivet - 2008

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http://atvb.ahajournals.org/cgi/content/full/28/1/180

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Frikke-Schmidt, R., Nordestgaard, BG., Jensen, G. B., Steffensen, R., Tybjaerg-Hansen, A., Nordestgaard, B. G., Tybjaerg-Hansen, A., Frikke-Schmidt, R., & Steffensen, R. (2008). Genetic variation in ABCA1 predicts ischemic heart disease in the general population. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(1), 180-6. https://doi.org/10.1161/ATVBAHA.107.153858, https://doi.org/10.1161/ATVBAHA.107.153858

Frikke-Schmidt, R, Nordestgaard, BG, Jensen, GB, Steffensen, R, Tybjaerg-Hansen, A, Nordestgaard, BG , Tybjaerg-Hansen, A, Frikke-Schmidt, R & Steffensen, R 2008, 'Genetic variation in ABCA1 predicts ischemic heart disease in the general population', Arteriosclerosis, Thrombosis, and Vascular Biology, bind 28, nr. 1, s. 180-6. https://doi.org/10.1161/ATVBAHA.107.153858, https://doi.org/10.1161/ATVBAHA.107.153858

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abstract = "We tested the hypothesis that 6 nonsynonymous single nucleotide polymorphisms (SNPs) in ATP-Binding-Cassette transporter A1 (ABCA1) affect risk of ischemic heart disease (IHD) in the general population.",

author = "Ruth Frikke-Schmidt and BG Nordestgaard and Jensen, {Gorm B} and R Steffensen and A Tybjaerg-Hansen and Nordestgaard, {B{\o}rge G} and Anne Tybjaerg-Hansen and Ruth Frikke-Schmidt and Rolf Steffensen",

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AB - We tested the hypothesis that 6 nonsynonymous single nucleotide polymorphisms (SNPs) in ATP-Binding-Cassette transporter A1 (ABCA1) affect risk of ischemic heart disease (IHD) in the general population.

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Genetic variation in ABCA1 predicts ischemic heart disease in the general population

Abstract

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