Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

TY - JOUR

T1 - Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

AU - Okbay, Aysu

AU - Baselmans, Bart M L

AU - De Neve, Jan-Emmanuel

AU - Turley, Patrick

AU - Nivard, Michel G

AU - Fontana, Mark Alan

AU - Meddens, S Fleur W

AU - Linnér, Richard Karlsson

AU - Rietveld, Cornelius A

AU - Derringer, Jaime

AU - Gratten, Jacob

AU - Lee, James J

AU - Liu, Jimmy Z

AU - de Vlaming, Ronald

AU - Ahluwalia, Tarun Veer Singh

AU - Buchwald, Jadwiga

AU - Cavadino, Alana

AU - Frazier-Wood, Alexis C

AU - Furlotte, Nicholas A

AU - Garfield, Victoria

AU - Geisel, Marie Henrike

AU - Gonzalez, Juan R

AU - Haitjema, Saskia

AU - Karlsson, Robert

AU - van der Laan, Sander W

AU - Ladwig, Karl-Heinz

AU - Lahti, Jari

AU - van der Lee, Sven J

AU - Lind, Penelope A

AU - Liu, Tian

AU - Matteson, Lindsay

AU - Mihailov, Evelin

AU - Miller, Michael B

AU - Minica, Camelia C

AU - Nolte, Ilja M

AU - Mook-Kanamori, Dennis

AU - van der Most, Peter J

AU - Oldmeadow, Christopher

AU - Qian, Yong

AU - Raitakari, Olli

AU - Rawal, Rajesh

AU - Realo, Anu

AU - Rueedi, Rico

AU - Schmidt, Börge

AU - Smith, Albert V

AU - Stergiakouli, Evie

AU - Tanaka, Toshiko

AU - Bültmann, Ute

AU - Hansen, Torben

AU - Sørensen, Thorkild I A

AU - LifeLines Cohort Study

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

AB - Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

KW - Journal Article

U2 - 10.1038/ng.3552

DO - 10.1038/ng.3552

M3 - Journal article

C2 - 27089181

SN - 1061-4036

VL - 48

SP - 624

EP - 633

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -