Genetic control of disease in an experimental model for Sjögren's syndrome

TY - JOUR

T1 - Genetic control of disease in an experimental model for Sjögren's syndrome

AU - Andersson, Åsa Inga Maria

N1 - Keywords: Animals; Chromosome Mapping; Disease Models, Animal; Genetic Predisposition to Disease; Mice; Mice, Inbred NOD; Sjogren's Syndrome

PY - 2009

Y1 - 2009

N2 - Sjögren's syndrome is an autoimmune disease with a complex etiology depending on hereditary and environmental factors. The disease is characterized by lymphocytic infiltration and inflammation in the salivary and lacrimal glands, leading to oral and ocular dryness. To understand the genetic susceptibility in Sjögren's syndrome, studies of disease phenotypes have been performed in the non-obese diabetic (NOD) mouse. By the identification of genetic regions controlling development of autoimmune exocrinopathy in the NOD mouse and by reducing one of these regions considerably, Nguyen et al. in a recent issue of Arthritis Research and Therapy propose candidate genes for development of Sjögren's syndrome.

AB - Sjögren's syndrome is an autoimmune disease with a complex etiology depending on hereditary and environmental factors. The disease is characterized by lymphocytic infiltration and inflammation in the salivary and lacrimal glands, leading to oral and ocular dryness. To understand the genetic susceptibility in Sjögren's syndrome, studies of disease phenotypes have been performed in the non-obese diabetic (NOD) mouse. By the identification of genetic regions controlling development of autoimmune exocrinopathy in the NOD mouse and by reducing one of these regions considerably, Nguyen et al. in a recent issue of Arthritis Research and Therapy propose candidate genes for development of Sjögren's syndrome.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1186/ar2583

DO - 10.1186/ar2583

M3 - Journal article

C2 - 19216731

SN - 1478-6362

VL - 11

SP - 102

JO - Arthritis Research & Therapy

JF - Arthritis Research & Therapy

IS - 1

ER -