Genetic characterization of Somali and Iraqi populations using a set of 33 X-chromosome Indels.

TY - GEN

T1 - Genetic characterization of Somali and Iraqi populations using a set of 33 X-chromosome Indels.

AU - Pereira, Vania

AU - Moncada, Enrique

AU - Diez, Isabel Eugenia

AU - Tomas Mas, Carmen

AU - Amorim, Antonio

AU - Morling, Niels

AU - Gusmão, Leonor

AU - Prata, Maria João

PY - 2011/12

Y1 - 2011/12

N2 - The genotyping of insertion-deletion polymorphisms (Indels) has gained importance in population studies and human identification over the last few years and so has the study of the X-chromosome markers. In the present work, 245 samples from unrelated individuals from Somalia (148 males) and Iraq (58 males and 39 females) were analysed for 33 X-chromosome Indel markers. The aim was to characterize the diversity pattern in both populations, contributing at the same time to a better understanding of the genetic landscape of the Horn of Africa and the Middle East. Although intrapopulation diversity values for the Somali and Iraqi populations were similar, significant FST values were obtained between the groups. No departure from Hardy-Weinberg equilibrium was detected in the subset of 39 Iraqi women. Linkage disequilibrium analyses revealed significant association in some pairs of markers in Somalis (MID3690-MID2089; MID3719-MID2089; MID357-MID356) and Iraqis (MID3719-MID2089; MID357-MID356). Overall, statistical parameters for forensic efficiency presented high values. The results of the analyses of forensically relevant statistical parameters suggest that the 33plex system can be used for human identification and kinship testing in Somalis and Iraqis and most likely in other populations as well.

AB - The genotyping of insertion-deletion polymorphisms (Indels) has gained importance in population studies and human identification over the last few years and so has the study of the X-chromosome markers. In the present work, 245 samples from unrelated individuals from Somalia (148 males) and Iraq (58 males and 39 females) were analysed for 33 X-chromosome Indel markers. The aim was to characterize the diversity pattern in both populations, contributing at the same time to a better understanding of the genetic landscape of the Horn of Africa and the Middle East. Although intrapopulation diversity values for the Somali and Iraqi populations were similar, significant FST values were obtained between the groups. No departure from Hardy-Weinberg equilibrium was detected in the subset of 39 Iraqi women. Linkage disequilibrium analyses revealed significant association in some pairs of markers in Somalis (MID3690-MID2089; MID3719-MID2089; MID357-MID356) and Iraqis (MID3719-MID2089; MID357-MID356). Overall, statistical parameters for forensic efficiency presented high values. The results of the analyses of forensically relevant statistical parameters suggest that the 33plex system can be used for human identification and kinship testing in Somalis and Iraqis and most likely in other populations as well.

U2 - 10.1016/j.fsigss.2011.08.069

DO - 10.1016/j.fsigss.2011.08.069

M3 - Conference article

SN - 1875-1768

VL - 3

SP - e137-e138

JO - Forensic Science International: Genetics Supplement Series

JF - Forensic Science International: Genetics Supplement Series

IS - 1

ER -