Genetic and environmental determinants of 25-hydroxyvitamin D levels in multiple sclerosis

Julie H. Laursen; Helle Bach Søndergaard; Anders Albrechtsen; Ruth Frikke-Schmidt; Nils Koch-Henriksen; Per Soelberg Sørensen; Finn Thorup Sellebjerg; Annette Bang Oturai

doi:10.1177/1352458514563590

Genetic and environmental determinants of 25-hydroxyvitamin D levels in multiple sclerosis

Julie H. Laursen, Helle Bach Søndergaard, Anders Albrechtsen, Ruth Frikke-Schmidt, Nils Koch-Henriksen, Per Soelberg Sørensen, Finn Thorup Sellebjerg, Annette Bang Oturai

12 Citationer (Scopus)

Abstract

BACKGROUND: Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant associations between 25-hydroxyvitamin D (25(OH)D) and single nucleotide polymorphisms (SNPs) in key genes in the vitamin D metabolism.
OBJECTIVE: To examine the association between 25(OH)D and six GWAS SNPs and environmental factors in 1497 MS patients.METHODS: Blood samples and lifestyle questionnaires were collected between 2009 and 2012. Genotyping of GC-, CYP2R1- and NADSYN1-SNPs was performed by TaqMan allelic discrimination (Life Technologies).RESULTS: We found significant associations between 25(OH)D and SNPs in GC (rs7041, p = 0.01 and rs2282679, p = 0.03) and CYP2R1 (rs10741657, p =1.8 × 10(-4)). Season of blood sampling (p = 2.8 × 10(-31)), sex (p = 1.9 × 10(-5)), BMI (p = 2.3 × 10(-5)), vitamin supplements (p = 7.0 × 10(-22)), and fish intake (p = 0.02) also had significant effects on 25(OH)D.CONCLUSION: In this cross-sectional study, we found significant effects of environmental factors and SNPs in GC and CYP2R1 on 25(OH)D in MS patients. Since 25(OH)D might have protective effects in MS, and vitamin D supply is a modifiable factor, it may be important to include this in the MS treatment regimen.

Originalsprog	Engelsk
Tidsskrift	Multiple Sclerosis Journal
Vol/bind	21
Udgave nummer	11
Sider (fra-til)	1414-1422
Antal sider	9
ISSN	1352-4585
DOI	https://doi.org/10.1177/1352458514563590
Status	Udgivet - 1 okt. 2015

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10.1177/1352458514563590

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title = "Genetic and environmental determinants of 25-hydroxyvitamin D levels in multiple sclerosis",

abstract = "BACKGROUND: Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant associations between 25-hydroxyvitamin D (25(OH)D) and single nucleotide polymorphisms (SNPs) in key genes in the vitamin D metabolism.OBJECTIVE: To examine the association between 25(OH)D and six GWAS SNPs and environmental factors in 1497 MS patients.METHODS: Blood samples and lifestyle questionnaires were collected between 2009 and 2012. Genotyping of GC-, CYP2R1- and NADSYN1-SNPs was performed by TaqMan allelic discrimination (Life Technologies).RESULTS: We found significant associations between 25(OH)D and SNPs in GC (rs7041, p = 0.01 and rs2282679, p = 0.03) and CYP2R1 (rs10741657, p =1.8 × 10(-4)). Season of blood sampling (p = 2.8 × 10(-31)), sex (p = 1.9 × 10(-5)), BMI (p = 2.3 × 10(-5)), vitamin supplements (p = 7.0 × 10(-22)), and fish intake (p = 0.02) also had significant effects on 25(OH)D.CONCLUSION: In this cross-sectional study, we found significant effects of environmental factors and SNPs in GC and CYP2R1 on 25(OH)D in MS patients. Since 25(OH)D might have protective effects in MS, and vitamin D supply is a modifiable factor, it may be important to include this in the MS treatment regimen.",

author = "Laursen, {Julie H.} and S{\o}ndergaard, {Helle Bach} and Anders Albrechtsen and Ruth Frikke-Schmidt and Nils Koch-Henriksen and S{\o}rensen, {Per Soelberg} and Sellebjerg, {Finn Thorup} and Oturai, {Annette Bang}",

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T1 - Genetic and environmental determinants of 25-hydroxyvitamin D levels in multiple sclerosis

AU - Laursen, Julie H.

AU - Søndergaard, Helle Bach

AU - Albrechtsen, Anders

AU - Frikke-Schmidt, Ruth

AU - Koch-Henriksen, Nils

AU - Sørensen, Per Soelberg

AU - Sellebjerg, Finn Thorup

AU - Oturai, Annette Bang

PY - 2015/10/1

Y1 - 2015/10/1

N2 - BACKGROUND: Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant associations between 25-hydroxyvitamin D (25(OH)D) and single nucleotide polymorphisms (SNPs) in key genes in the vitamin D metabolism.OBJECTIVE: To examine the association between 25(OH)D and six GWAS SNPs and environmental factors in 1497 MS patients.METHODS: Blood samples and lifestyle questionnaires were collected between 2009 and 2012. Genotyping of GC-, CYP2R1- and NADSYN1-SNPs was performed by TaqMan allelic discrimination (Life Technologies).RESULTS: We found significant associations between 25(OH)D and SNPs in GC (rs7041, p = 0.01 and rs2282679, p = 0.03) and CYP2R1 (rs10741657, p =1.8 × 10(-4)). Season of blood sampling (p = 2.8 × 10(-31)), sex (p = 1.9 × 10(-5)), BMI (p = 2.3 × 10(-5)), vitamin supplements (p = 7.0 × 10(-22)), and fish intake (p = 0.02) also had significant effects on 25(OH)D.CONCLUSION: In this cross-sectional study, we found significant effects of environmental factors and SNPs in GC and CYP2R1 on 25(OH)D in MS patients. Since 25(OH)D might have protective effects in MS, and vitamin D supply is a modifiable factor, it may be important to include this in the MS treatment regimen.

AB - BACKGROUND: Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant associations between 25-hydroxyvitamin D (25(OH)D) and single nucleotide polymorphisms (SNPs) in key genes in the vitamin D metabolism.OBJECTIVE: To examine the association between 25(OH)D and six GWAS SNPs and environmental factors in 1497 MS patients.METHODS: Blood samples and lifestyle questionnaires were collected between 2009 and 2012. Genotyping of GC-, CYP2R1- and NADSYN1-SNPs was performed by TaqMan allelic discrimination (Life Technologies).RESULTS: We found significant associations between 25(OH)D and SNPs in GC (rs7041, p = 0.01 and rs2282679, p = 0.03) and CYP2R1 (rs10741657, p =1.8 × 10(-4)). Season of blood sampling (p = 2.8 × 10(-31)), sex (p = 1.9 × 10(-5)), BMI (p = 2.3 × 10(-5)), vitamin supplements (p = 7.0 × 10(-22)), and fish intake (p = 0.02) also had significant effects on 25(OH)D.CONCLUSION: In this cross-sectional study, we found significant effects of environmental factors and SNPs in GC and CYP2R1 on 25(OH)D in MS patients. Since 25(OH)D might have protective effects in MS, and vitamin D supply is a modifiable factor, it may be important to include this in the MS treatment regimen.

U2 - 10.1177/1352458514563590

DO - 10.1177/1352458514563590

M3 - Journal article

C2 - 25533295

SN - 1352-4585

VL - 21

SP - 1414

EP - 1422

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 11

ER -

Genetic and environmental determinants of 25-hydroxyvitamin D levels in multiple sclerosis

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