Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma

Jacob Ø Rasmussen; Sarah L von Holstein; Jan U Prause; Ben Vainer; Alastair B Hansen; André Fehr; Göran Stenman; Steffen Heegaard

doi:10.3892/or.2014.3345

Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma

Jacob Ø Rasmussen, Sarah L von Holstein, Jan U Prause, Ben Vainer, Alastair B Hansen, André Fehr, Göran Stenman, Steffen Heegaard

4 Citationer (Scopus)

Abstract

A 71-year-old female with a known history of primary hepatic neuroendocrine carcinoma, presented with a visual defect, proptosis and restricted eye movements of the right eye. Biopsies from the orbit and from the primary hepatic neuroendocrine carcinoma showed similar morphological and immunohistochemical features, and high-resolution, array-based comparative genomic hybridization demonstrated loss of one copy each of chromosomes 3 and 18, and gain of 1q both in the primary hepatic neuroendocrine carcinoma and in the orbital tumour. The orbital mass was diagnosed as a metastasis from the primary hepatic neuroendocrine carcinoma. Primary hepatic neuroendocrine tumours are extremely rare, and the orbit is an extremely rare location for a neuroendocrine carcinoma metastasis. This is the first reported case of an orbital metastasis with origin from a primary hepatic neuroendocrine carcinoma.

Originalsprog	Engelsk
Tidsskrift	Oncology Reports
Vol/bind	32
Udgave nummer	4
Sider (fra-til)	1447-1450
Antal sider	4
ISSN	1021-335X
DOI	https://doi.org/10.3892/or.2014.3345
Status	Udgivet - okt. 2014

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10.3892/or.2014.3345

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title = "Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma",

abstract = "A 71-year-old female with a known history of primary hepatic neuroendocrine carcinoma, presented with a visual defect, proptosis and restricted eye movements of the right eye. Biopsies from the orbit and from the primary hepatic neuroendocrine carcinoma showed similar morphological and immunohistochemical features, and high-resolution, array-based comparative genomic hybridization demonstrated loss of one copy each of chromosomes 3 and 18, and gain of 1q both in the primary hepatic neuroendocrine carcinoma and in the orbital tumour. The orbital mass was diagnosed as a metastasis from the primary hepatic neuroendocrine carcinoma. Primary hepatic neuroendocrine tumours are extremely rare, and the orbit is an extremely rare location for a neuroendocrine carcinoma metastasis. This is the first reported case of an orbital metastasis with origin from a primary hepatic neuroendocrine carcinoma.",

author = "Rasmussen, {Jacob {\O}} and {von Holstein}, {Sarah L} and Prause, {Jan U} and Ben Vainer and Hansen, {Alastair B} and Andr{\'e} Fehr and G{\"o}ran Stenman and Steffen Heegaard",

year = "2014",

month = oct,

doi = "10.3892/or.2014.3345",

language = "English",

volume = "32",

pages = "1447--1450 ",

journal = "Oncology Reports",

issn = "1021-335X",

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TY - JOUR

T1 - Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma

AU - Rasmussen, Jacob Ø

AU - von Holstein, Sarah L

AU - Prause, Jan U

AU - Vainer, Ben

AU - Hansen, Alastair B

AU - Fehr, André

AU - Stenman, Göran

AU - Heegaard, Steffen

PY - 2014/10

Y1 - 2014/10

N2 - A 71-year-old female with a known history of primary hepatic neuroendocrine carcinoma, presented with a visual defect, proptosis and restricted eye movements of the right eye. Biopsies from the orbit and from the primary hepatic neuroendocrine carcinoma showed similar morphological and immunohistochemical features, and high-resolution, array-based comparative genomic hybridization demonstrated loss of one copy each of chromosomes 3 and 18, and gain of 1q both in the primary hepatic neuroendocrine carcinoma and in the orbital tumour. The orbital mass was diagnosed as a metastasis from the primary hepatic neuroendocrine carcinoma. Primary hepatic neuroendocrine tumours are extremely rare, and the orbit is an extremely rare location for a neuroendocrine carcinoma metastasis. This is the first reported case of an orbital metastasis with origin from a primary hepatic neuroendocrine carcinoma.

AB - A 71-year-old female with a known history of primary hepatic neuroendocrine carcinoma, presented with a visual defect, proptosis and restricted eye movements of the right eye. Biopsies from the orbit and from the primary hepatic neuroendocrine carcinoma showed similar morphological and immunohistochemical features, and high-resolution, array-based comparative genomic hybridization demonstrated loss of one copy each of chromosomes 3 and 18, and gain of 1q both in the primary hepatic neuroendocrine carcinoma and in the orbital tumour. The orbital mass was diagnosed as a metastasis from the primary hepatic neuroendocrine carcinoma. Primary hepatic neuroendocrine tumours are extremely rare, and the orbit is an extremely rare location for a neuroendocrine carcinoma metastasis. This is the first reported case of an orbital metastasis with origin from a primary hepatic neuroendocrine carcinoma.

U2 - 10.3892/or.2014.3345

DO - 10.3892/or.2014.3345

M3 - Journal article

C2 - 25051214

SN - 1021-335X

VL - 32

SP - 1447

EP - 1450

JO - Oncology Reports

JF - Oncology Reports

IS - 4

ER -

Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma

Abstract

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