Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants

Medicin og biovidenskab

• Ceftazidime 18%
• Ciprofloxacin 16%
• Cystic Fibrosis 91%
• Focal Infection 23%
• Genes 37%
• Genetic Background 100%
• Genetic Variation 15%
• Infections 44%
• Loss of Function Mutation 17%
• Lung 50%
• Meropenem 19%
• Microbial Drug Resistance 15%
• Mutation 26%
• Mutation Rate 33%
• Phenotype 46%
• Population 6%
• Pseudomonas aeruginosa 86%
• Quorum Sensing 58%
• Radiation 11%
• Virulence 27%