@article{abf3fd4da0f549238073b82776254226,
title = "General synthesis of β-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors",
abstract = "Certain spiders contain large pools of polyamine toxins, which are putative pharmacological tools awaiting further discovery. Here we present a general synthesis strategy for this class of toxins and prepare five structurally varied polyamine toxins. Electrophysiological testing at three ionotropic glutamate receptor subtypes reveals that two of these, Nephila polyamine toxins 1 (NPTX-1) and 8 (NPTX-8), comprise intriguing pharmacological activities by having subnanomolar IC(50) values at kainate receptors.",
keywords = "Animals, Asparagine, Indoleacetic Acids, Molecular Structure, Polyamines, Receptors, Ionotropic Glutamate, Receptors, Kainic Acid, Spider Venoms, Spiders, Structure-Activity Relationship, Toxins, Biological, beta-Alanine",
author = "Simon Lucas and Poulsen, {Mette H} and N{\o}rager, {Niels G} and Barslund, {Anne F} and Bach, {Tinna B} and Kristensen, {Anders S} and Kristian Str{\o}mgaard",
year = "2012",
month = nov,
day = "26",
doi = "10.1021/jm301255m",
language = "English",
volume = "55",
pages = "10297--10301",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "22",
}