Gene expression heterogeneities in embryonic stem cell populations: origin and function

Alfonso Martinez Arias; Joshua M Brickman

doi:10.1016/j.ceb.2011.09.007

Gene expression heterogeneities in embryonic stem cell populations: origin and function

Alfonso Martinez Arias, Joshua M Brickman

Stem Cell and developmental Biology - early embryonic lineage specification

80 Citationer (Scopus)

Abstract

Stem and progenitor cells are populations of cells that retain the capacity to populate specific lineages and to transit this capacity through cell division. However, attempts to define markers for stem cells have met with limited success. Here we consider whether this limited success reflects an intrinsic requirement for heterogeneity with stem cell populations. We focus on Embryonic Stem (ES) cells, in vitro derived cell lines from the early embryo that are considered both pluripotent (able to generate all the lineages of the future embryo) and indefinitely self renewing. We examine the relevance of recently reported heterogeneities in ES cells and whether these heterogeneities themselves are inherent requirements of functional potency and self renewal.

Originalsprog	Engelsk
Tidsskrift	Current Opinion in Cell Biology
Vol/bind	23
Udgave nummer	6
Sider (fra-til)	650-6
Antal sider	7
ISSN	0955-0674
DOI	https://doi.org/10.1016/j.ceb.2011.09.007
Status	Udgivet - dec. 2011

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10.1016/j.ceb.2011.09.007

Citationsformater

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title = "Gene expression heterogeneities in embryonic stem cell populations: origin and function",

abstract = "Stem and progenitor cells are populations of cells that retain the capacity to populate specific lineages and to transit this capacity through cell division. However, attempts to define markers for stem cells have met with limited success. Here we consider whether this limited success reflects an intrinsic requirement for heterogeneity with stem cell populations. We focus on Embryonic Stem (ES) cells, in vitro derived cell lines from the early embryo that are considered both pluripotent (able to generate all the lineages of the future embryo) and indefinitely self renewing. We examine the relevance of recently reported heterogeneities in ES cells and whether these heterogeneities themselves are inherent requirements of functional potency and self renewal.",

keywords = "Cell Differentiation, Cell Division, Cell Line, Embryonic Stem Cells, Gene Expression Regulation, Developmental, Hematopoietic Stem Cells, Humans",

author = "{Martinez Arias}, Alfonso and Brickman, {Joshua M}",

year = "2011",

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T2 - origin and function

AU - Martinez Arias, Alfonso

AU - Brickman, Joshua M

PY - 2011/12

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N2 - Stem and progenitor cells are populations of cells that retain the capacity to populate specific lineages and to transit this capacity through cell division. However, attempts to define markers for stem cells have met with limited success. Here we consider whether this limited success reflects an intrinsic requirement for heterogeneity with stem cell populations. We focus on Embryonic Stem (ES) cells, in vitro derived cell lines from the early embryo that are considered both pluripotent (able to generate all the lineages of the future embryo) and indefinitely self renewing. We examine the relevance of recently reported heterogeneities in ES cells and whether these heterogeneities themselves are inherent requirements of functional potency and self renewal.

AB - Stem and progenitor cells are populations of cells that retain the capacity to populate specific lineages and to transit this capacity through cell division. However, attempts to define markers for stem cells have met with limited success. Here we consider whether this limited success reflects an intrinsic requirement for heterogeneity with stem cell populations. We focus on Embryonic Stem (ES) cells, in vitro derived cell lines from the early embryo that are considered both pluripotent (able to generate all the lineages of the future embryo) and indefinitely self renewing. We examine the relevance of recently reported heterogeneities in ES cells and whether these heterogeneities themselves are inherent requirements of functional potency and self renewal.

KW - Cell Differentiation

KW - Cell Division

KW - Cell Line

KW - Embryonic Stem Cells

KW - Gene Expression Regulation, Developmental

KW - Hematopoietic Stem Cells

KW - Humans

U2 - 10.1016/j.ceb.2011.09.007

DO - 10.1016/j.ceb.2011.09.007

M3 - Journal article

C2 - 21982544

SN - 0955-0674

VL - 23

SP - 650

EP - 656

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 6

ER -

Gene expression heterogeneities in embryonic stem cell populations: origin and function

Abstract

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