Gastric emptying and subjective symptoms of nausea: lack of effects of a 5-hydroxytryptamine-3 antagonist ondansetron on gastric emptying in patients with gastric stasis syndrome

TY - JOUR

T1 - Gastric emptying and subjective symptoms of nausea

T2 - lack of effects of a 5-hydroxytryptamine-3 antagonist ondansetron on gastric emptying in patients with gastric stasis syndrome

AU - Nielsen, O H

AU - Hvid-Jacobsen, K

AU - Lund, P

AU - Langholz, E

PY - 1990

Y1 - 1990

N2 - Thirty-seven consecutive patients referred to a regional gastroenterology outpatient clinic with complaints of persistent nausea had a double isotopic scintigraphic evaluation of solid and liquid gastric emptying. Gastric emptying of both forms followed an exponential model. Marked day to day variation of gastric emptying was noted with a coefficient of variation of approximately 0.20 for both phases. Only 9 of 37 patients had delayed gastric emptying rate of the solid component (greater than 180 min) and no correlation between gastric stasis syndrome and nausea was established. Among these patients the median time for the stomach to empty 50% of the solid component was 261 min and 50% of the liquid component was 66 min. Treatment of these 9 patients shown to have gastric stasis syndrome and further 3 patients with diabetic gastroparesis with ondansetron, a highly selective antagonist of 5-hydroxytryptamine-3-receptors, resulted in a gastric emptying rate which was not statistically faster than after placebo (p = 0.11).

AB - Thirty-seven consecutive patients referred to a regional gastroenterology outpatient clinic with complaints of persistent nausea had a double isotopic scintigraphic evaluation of solid and liquid gastric emptying. Gastric emptying of both forms followed an exponential model. Marked day to day variation of gastric emptying was noted with a coefficient of variation of approximately 0.20 for both phases. Only 9 of 37 patients had delayed gastric emptying rate of the solid component (greater than 180 min) and no correlation between gastric stasis syndrome and nausea was established. Among these patients the median time for the stomach to empty 50% of the solid component was 261 min and 50% of the liquid component was 66 min. Treatment of these 9 patients shown to have gastric stasis syndrome and further 3 patients with diabetic gastroparesis with ondansetron, a highly selective antagonist of 5-hydroxytryptamine-3-receptors, resulted in a gastric emptying rate which was not statistically faster than after placebo (p = 0.11).

KW - Adult

KW - Double-Blind Method

KW - Female

KW - Gastric Emptying/drug effects

KW - Humans

KW - Imidazoles/therapeutic use

KW - Male

KW - Middle Aged

KW - Nausea/drug therapy

KW - Ondansetron

KW - Serotonin Antagonists

KW - Syndrome

U2 - 10.1159/000200337

DO - 10.1159/000200337

M3 - Journal article

C2 - 2147664

SN - 0012-2823

VL - 46

SP - 89

EP - 96

JO - Digestion

JF - Digestion

IS - 2

ER -