TY - JOUR
T1 - Gain of chromosomal region 20q and loss of 18 discriminates between Lynch syndrome and familial colorectal cancer
AU - Therkildsen, Christina
AU - Jönsson, Göran
AU - Dominguez-Valentin, Mev
AU - Nissen, Anja
AU - Rambech, Eva
AU - Halvarsson, Britta
AU - Bernstein, Inge
AU - Borg, Ke
AU - Nilbert, Mef
N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.
PY - 2013/4
Y1 - 2013/4
N2 - Lynch syndrome and familial colorectal cancer type X, FCCTX, represent the two predominant colorectal cancer syndromes. Whereas Lynch syndrome is clinically and genetically well defined, the genetic cause of FCCTX is unknown and genomic differences between Lynch syndrome and FCCTX tumours are largely unknown. We applied array-based comparative genomic hybridisation to 23 colorectal cancers from FCCTX with comparison to 23 Lynch syndrome tumours and to 45 sporadic colorectal cancers. FCCTX tumours showed genomic complexity with frequent gains on chromosomes 20q, 19 and 17 and losses of 18, 8p and 15. Gain of genetic material in two separate regions encompassing, 20q12-13.12 and 20q13.2-13.32, was identified in 65% of the FCCTX tumours. Gain of material on chromosome 20q and loss on chromosome 18 significantly discriminated colorectal cancers associated with FCCTX from Lynch syndrome, which likely signifies different preferred tumourigenic pathways.
AB - Lynch syndrome and familial colorectal cancer type X, FCCTX, represent the two predominant colorectal cancer syndromes. Whereas Lynch syndrome is clinically and genetically well defined, the genetic cause of FCCTX is unknown and genomic differences between Lynch syndrome and FCCTX tumours are largely unknown. We applied array-based comparative genomic hybridisation to 23 colorectal cancers from FCCTX with comparison to 23 Lynch syndrome tumours and to 45 sporadic colorectal cancers. FCCTX tumours showed genomic complexity with frequent gains on chromosomes 20q, 19 and 17 and losses of 18, 8p and 15. Gain of genetic material in two separate regions encompassing, 20q12-13.12 and 20q13.2-13.32, was identified in 65% of the FCCTX tumours. Gain of material on chromosome 20q and loss on chromosome 18 significantly discriminated colorectal cancers associated with FCCTX from Lynch syndrome, which likely signifies different preferred tumourigenic pathways.
U2 - 10.1016/j.ejca.2012.11.011
DO - 10.1016/j.ejca.2012.11.011
M3 - Journal article
C2 - 23245329
SN - 0959-8049
JO - European Journal of Cancer, Supplement
JF - European Journal of Cancer, Supplement
ER -
