Fungal innate immunity induced by bacterial microbe-associated molecular patterns (MAMPs)

TY - JOUR

T1 - Fungal innate immunity induced by bacterial microbe-associated molecular patterns (MAMPs)

AU - Ip Cho, Simon

AU - Sundelin, Thomas

AU - Erbs, Gitte

AU - Kistler, H Corby

AU - Newman, Mari-Anne

AU - Olsson, Stefan

N1 - Copyright © 2016 Ipcho et al.

PY - 2016

Y1 - 2016

N2 - Plants and animals detect bacterial presence through Microbe-Associated Molecular Patterns (MAMPs) which induce an innate immune response. The field of fungal-bacterial interaction at the molecular level is still in its infancy and little is known about MAMPs and their detection by fungi. Exposing Fusarium graminearum to bacterial MAMPs led to increased fungal membrane hyperpolarization, a putative defense response, and a range of transcriptional responses. The fungus reacted with a different transcript profile to each of the three tested MAMPs, although a core set of genes related to energy generation, transport, amino acid production, secondary metabolism, and especially iron uptake were detected for all three. Half of the genes related to iron uptake were predicted MirA type transporters that potentially take up bacterial siderophores. These quick responses can be viewed as a preparation for further interactions with beneficial or pathogenic bacteria, and constitute a fungal innate immune response with similarities to those of plants and animals.

AB - Plants and animals detect bacterial presence through Microbe-Associated Molecular Patterns (MAMPs) which induce an innate immune response. The field of fungal-bacterial interaction at the molecular level is still in its infancy and little is known about MAMPs and their detection by fungi. Exposing Fusarium graminearum to bacterial MAMPs led to increased fungal membrane hyperpolarization, a putative defense response, and a range of transcriptional responses. The fungus reacted with a different transcript profile to each of the three tested MAMPs, although a core set of genes related to energy generation, transport, amino acid production, secondary metabolism, and especially iron uptake were detected for all three. Half of the genes related to iron uptake were predicted MirA type transporters that potentially take up bacterial siderophores. These quick responses can be viewed as a preparation for further interactions with beneficial or pathogenic bacteria, and constitute a fungal innate immune response with similarities to those of plants and animals.

KW - Journal Article

U2 - 10.1534/g3.116.027987

DO - 10.1534/g3.116.027987

M3 - Journal article

C2 - 27172188

SN - 2160-1836

VL - 6

SP - 1585

EP - 1595

JO - G3: Genes, Genomes, Genetics (Bethesda)

JF - G3: Genes, Genomes, Genetics (Bethesda)

IS - 6

ER -