@inbook{6af6bc48fb2447e984d96f0e1e213d11,
title = "Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors",
abstract = "During co-evolution with their hosts, viruses have developed several survival strategies that involve exploitation of 7TM receptors. These include virus-encoded 7TM receptors and ligands and viral regulation of endogenous receptors. Many functional properties have been ascribed to virus-exploited 7TM receptors, and although the list of putative functions is steadily growing, the presence and/or utilization of 7TM receptors are still poorly understood for many of these. This review focuses on three well described functional properties: 1) the immune evasion strategies, exemplified by γ1-herpesvirus-encoded BILF1 receptors, the human cytomegalovirus (HCMV)-encoded US28 receptor and the Epstein-Barr virus (EBV)-regulated EBI2 (or GPR183), 2) the tissue tropism and virus-dissemination properties, exemplified by the murine CMV-encoded M33, and 3) the tumorigenic properties, exemplified by the human herpesvirus 8 (HHV8)-encoded ORF74, HCMV-US28 and EBV-BILF1. Given the general high “druggability” of 7TM receptors, and the recent progress in the understanding of in particular immune evasive functions of the virus-exploited 7TM receptors, we put a special emphasis on the progress of novel anti-viral therapeutic tools ",
author = "Katja Spiess and Rosenkilde, {Mette Marie}",
year = "2014",
language = "English",
isbn = " 978-1-62703-778-5 ",
series = "Methods in Pharmacology and Toxicology",
publisher = "Humana Press",
pages = "45--64",
editor = "Stevens, {Craig W.}",
booktitle = "G Protein-Coupled Receptor Genetics",
address = "United States",
}