Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck

TY - JOUR

T1 - Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck

AU - Thurfjell, Niklas

AU - Coates, Philip J

AU - Boldrup, Linda

AU - Lindgren, Britta

AU - Bäcklund, Bodil

AU - Uusitalo, Tony

AU - Mahani, David

AU - Dabelsteen, Erik

AU - Dahlqvist, Ake

AU - Sjöström, Björn

AU - Roos, Göran

AU - Vojtesek, Borek

AU - Nenutil, Rudolf

AU - Nylander, Karin

PY - 2005

Y1 - 2005

N2 - BACKGROUND/AIMS: Squamous cell carcinoma of the head and neck (HNSCC) is the 6th most common malignancy worldwide with a 5-year survival that has not improved over the last 20-25 years. Factors of prognostic significance for this tumour type include the presence of regional lymph node metastasis and amplification of chromosome 3q21-29, where the p63 gene is located. This gene encodes 6 proteins and is crucial for formation of the oral mucosa, teeth, salivary glands and skin. Each of the 6 different p63 proteins has different characteristics and functions, where some resemble the tumour suppressor protein p53, whilst others have functions that oppose p53.METHODS: To understand the function and importance of p63 in oral mucosa and tumour development we have studied protein as well as mRNA expression in normal oral mucosa and tumours.RESULTS/CONCLUSION: Expression of p63 proteins differs between the cell layers in normal oral mucosa, and primary HNSCC has a high expression level of p63 isoforms normally expressed in basal cells. Data suggest that p63 expression in HNSCC influences tumour cell differentiation.

AB - BACKGROUND/AIMS: Squamous cell carcinoma of the head and neck (HNSCC) is the 6th most common malignancy worldwide with a 5-year survival that has not improved over the last 20-25 years. Factors of prognostic significance for this tumour type include the presence of regional lymph node metastasis and amplification of chromosome 3q21-29, where the p63 gene is located. This gene encodes 6 proteins and is crucial for formation of the oral mucosa, teeth, salivary glands and skin. Each of the 6 different p63 proteins has different characteristics and functions, where some resemble the tumour suppressor protein p53, whilst others have functions that oppose p53.METHODS: To understand the function and importance of p63 in oral mucosa and tumour development we have studied protein as well as mRNA expression in normal oral mucosa and tumours.RESULTS/CONCLUSION: Expression of p63 proteins differs between the cell layers in normal oral mucosa, and primary HNSCC has a high expression level of p63 isoforms normally expressed in basal cells. Data suggest that p63 expression in HNSCC influences tumour cell differentiation.

KW - Biopsy, Needle

KW - Carcinoma, Squamous Cell

KW - Case-Control Studies

KW - DNA, Neoplasm

KW - Female

KW - Gene Expression Regulation, Neoplastic

KW - Head and Neck Neoplasms

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Mouth Mucosa

KW - Prognosis

KW - Reference Values

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Risk Assessment

KW - Sampling Studies

KW - Sensitivity and Specificity

KW - Survival Rate

KW - Tumor Markers, Biological

KW - Tumor Suppressor Protein p53

U2 - 10.1159/000082464

DO - 10.1159/000082464

M3 - Journal article

C2 - 15608417

SN - 0065-3071

VL - 62

SP - 49

EP - 57

JO - Advances in Oto-Rhino-Laryngology

JF - Advances in Oto-Rhino-Laryngology

ER -