Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus

U. Nubel; P. Roumagnac; M. Feldkamp; J.H. Song; K.S. Ko; Y.C. Huang; G. Coombs; M. Ip; R. Skov; M.J. Struelens; R.V. Goering; B. Strommenger; A. Weller; W. Witte; M. Achtman; Henrik T. Westh

Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus

U. Nubel, P. Roumagnac, M. Feldkamp, J.H. Song, K.S. Ko, Y.C. Huang, G. Coombs, M. Ip, R. Skov, M.J. Struelens, R.V. Goering, B. Strommenger, A. Weller, W. Witte, M. Achtman, Henrik T. Westh

196 Citationer (Scopus)

Abstract

A small number of clonal lineages dominates the global population structure of methicillin-resistant Staphylococcus aureus (MRSA), resulting in the concept that MRSA has emerged on a few occasions after penicillinase-stable beta-lactam antibiotics were introduced to clinical practice, followed by intercontinental spread of individual clones. We investigated the evolutionary history of an MRSA clone (ST5) by mutation discovery at 108 loci (46 kb) within a global collection of 135 isolates. The SNPs that were ascertained define a radial phylogenetic structure within ST5 consisting of at least 5 chains of mutational steps that define geographically associated clades. These clades are not concordant with previously described groupings based on staphylococcal protein A gene (spa) typing. By mapping the number of independent imports of the staphylococcal cassette chromosome methicillin-resistance island, we also show that import has occurred on at least 23 occasions within this single sequence type and that the progeny of such recombinant strains usually are distributed locally rather than globally. These results provide strong evidence that geographical spread of MRSA over long distances and across cultural borders is a rare event compared with the frequency with which the staphylococcal cassette chromosome island has been imported
Udgivelsesdato: 2008/9/16

Originalsprog	Engelsk
Tidsskrift	Proceedings of the National Academy of Science of the United States of America
Vol/bind	105
Udgave nummer	37
Sider (fra-til)	14130-14135
Antal sider	5
ISSN	0027-8424
Status	Udgivet - 2008

Citationsformater

Nubel, U., Roumagnac, P., Feldkamp, M., Song, J. H., Ko, K. S., Huang, Y. C., Coombs, G., Ip, M., Skov, R., Struelens, M. J., Goering, R. V., Strommenger, B., Weller, A., Witte, W., Achtman, M., & Westh, H. T. (2008). Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus. Proceedings of the National Academy of Science of the United States of America, 105(37), 14130-14135.

Nubel, U, Roumagnac, P, Feldkamp, M, Song, JH, Ko, KS, Huang, YC, Coombs, G, Ip, M, Skov, R, Struelens, MJ, Goering, RV, Strommenger, B, Weller, A, Witte, W, Achtman, M & Westh, HT 2008, 'Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus', Proceedings of the National Academy of Science of the United States of America, bind 105, nr. 37, s. 14130-14135.

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title = "Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus",

abstract = "A small number of clonal lineages dominates the global population structure of methicillin-resistant Staphylococcus aureus (MRSA), resulting in the concept that MRSA has emerged on a few occasions after penicillinase-stable beta-lactam antibiotics were introduced to clinical practice, followed by intercontinental spread of individual clones. We investigated the evolutionary history of an MRSA clone (ST5) by mutation discovery at 108 loci (46 kb) within a global collection of 135 isolates. The SNPs that were ascertained define a radial phylogenetic structure within ST5 consisting of at least 5 chains of mutational steps that define geographically associated clades. These clades are not concordant with previously described groupings based on staphylococcal protein A gene (spa) typing. By mapping the number of independent imports of the staphylococcal cassette chromosome methicillin-resistance island, we also show that import has occurred on at least 23 occasions within this single sequence type and that the progeny of such recombinant strains usually are distributed locally rather than globally. These results provide strong evidence that geographical spread of MRSA over long distances and across cultural borders is a rare event compared with the frequency with which the staphylococcal cassette chromosome island has been imported Udgivelsesdato: 2008/9/16",

author = "U. Nubel and P. Roumagnac and M. Feldkamp and J.H. Song and K.S. Ko and Y.C. Huang and G. Coombs and M. Ip and R. Skov and M.J. Struelens and R.V. Goering and B. Strommenger and A. Weller and W. Witte and M. Achtman and Westh, {Henrik T.}",

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T1 - Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus

AU - Nubel, U.

AU - Roumagnac, P.

AU - Feldkamp, M.

AU - Song, J.H.

AU - Ko, K.S.

AU - Huang, Y.C.

AU - Coombs, G.

AU - Ip, M.

AU - Skov, R.

AU - Struelens, M.J.

AU - Goering, R.V.

AU - Strommenger, B.

AU - Weller, A.

AU - Witte, W.

AU - Achtman, M.

AU - Westh, Henrik T.

PY - 2008

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N2 - A small number of clonal lineages dominates the global population structure of methicillin-resistant Staphylococcus aureus (MRSA), resulting in the concept that MRSA has emerged on a few occasions after penicillinase-stable beta-lactam antibiotics were introduced to clinical practice, followed by intercontinental spread of individual clones. We investigated the evolutionary history of an MRSA clone (ST5) by mutation discovery at 108 loci (46 kb) within a global collection of 135 isolates. The SNPs that were ascertained define a radial phylogenetic structure within ST5 consisting of at least 5 chains of mutational steps that define geographically associated clades. These clades are not concordant with previously described groupings based on staphylococcal protein A gene (spa) typing. By mapping the number of independent imports of the staphylococcal cassette chromosome methicillin-resistance island, we also show that import has occurred on at least 23 occasions within this single sequence type and that the progeny of such recombinant strains usually are distributed locally rather than globally. These results provide strong evidence that geographical spread of MRSA over long distances and across cultural borders is a rare event compared with the frequency with which the staphylococcal cassette chromosome island has been imported Udgivelsesdato: 2008/9/16

AB - A small number of clonal lineages dominates the global population structure of methicillin-resistant Staphylococcus aureus (MRSA), resulting in the concept that MRSA has emerged on a few occasions after penicillinase-stable beta-lactam antibiotics were introduced to clinical practice, followed by intercontinental spread of individual clones. We investigated the evolutionary history of an MRSA clone (ST5) by mutation discovery at 108 loci (46 kb) within a global collection of 135 isolates. The SNPs that were ascertained define a radial phylogenetic structure within ST5 consisting of at least 5 chains of mutational steps that define geographically associated clades. These clades are not concordant with previously described groupings based on staphylococcal protein A gene (spa) typing. By mapping the number of independent imports of the staphylococcal cassette chromosome methicillin-resistance island, we also show that import has occurred on at least 23 occasions within this single sequence type and that the progeny of such recombinant strains usually are distributed locally rather than globally. These results provide strong evidence that geographical spread of MRSA over long distances and across cultural borders is a rare event compared with the frequency with which the staphylococcal cassette chromosome island has been imported Udgivelsesdato: 2008/9/16

M3 - Journal article

SN - 0027-8424

VL - 105

SP - 14130

EP - 14135

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 37

ER -