Frequency of glucocorticoid resistance and dependency in Crohn's disease

P Munkholm; E Langholz; M Davidsen; V Binder

doi:10.1136/gut.35.3.360

Frequency of glucocorticoid resistance and dependency in Crohn's disease

P Munkholm, E Langholz, M Davidsen, V Binder

Institut for Klinisk Medicin

622 Citationer (Scopus)

Abstract

The outcome of the first steroid treatment course was prospectively studied in a regional cohort of 196 patients with Crohn's disease diagnosed 1979-1987. The immediate outcome after 30 days, and the prolonged outcome 30 days after treatment had stopped, are described. In all 109 patients treatment was analysed. Complete remission was obtained in 48%, partial remission in 32%, and no response in 20% within 30 days of treatment. Among primary responders (complete and partial remission), 55% remained in prolonged response after treatment had finished, while 45% relapsed or could not be withdrawn from treatment within one year. Localisation of disease, age, sex or clinical symptoms did not significantly correlate with outcome, which can be summarised as prolonged steroid response in 44%, steroid dependency in 36%, and steroid resistant in 20% of the patients.

Originalsprog	Engelsk
Tidsskrift	Gut
Vol/bind	35
Udgave nummer	3
Sider (fra-til)	360-2
Antal sider	3
ISSN	0017-5749
DOI	https://doi.org/10.1136/gut.35.3.360
Status	Udgivet - mar. 1994

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10.1136/gut.35.3.360

Citationsformater

@article{e062657797e941958e65c1a7ce0fd225,

title = "Frequency of glucocorticoid resistance and dependency in Crohn's disease",

abstract = "The outcome of the first steroid treatment course was prospectively studied in a regional cohort of 196 patients with Crohn's disease diagnosed 1979-1987. The immediate outcome after 30 days, and the prolonged outcome 30 days after treatment had stopped, are described. In all 109 patients treatment was analysed. Complete remission was obtained in 48%, partial remission in 32%, and no response in 20% within 30 days of treatment. Among primary responders (complete and partial remission), 55% remained in prolonged response after treatment had finished, while 45% relapsed or could not be withdrawn from treatment within one year. Localisation of disease, age, sex or clinical symptoms did not significantly correlate with outcome, which can be summarised as prolonged steroid response in 44%, steroid dependency in 36%, and steroid resistant in 20% of the patients.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Child, Cohort Studies, Crohn Disease/drug therapy, Drug Resistance, Female, Humans, Male, Middle Aged, Prednisolone/therapeutic use, Prospective Studies, Time Factors, Treatment Outcome",

author = "P Munkholm and E Langholz and M Davidsen and V Binder",

year = "1994",

month = mar,

doi = "10.1136/gut.35.3.360",

language = "English",

volume = "35",

pages = "360--2",

journal = "Gut",

issn = "0017-5749",

publisher = "B M J Group",

number = "3",

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TY - JOUR

T1 - Frequency of glucocorticoid resistance and dependency in Crohn's disease

AU - Munkholm, P

AU - Langholz, E

AU - Davidsen, M

AU - Binder, V

PY - 1994/3

Y1 - 1994/3

N2 - The outcome of the first steroid treatment course was prospectively studied in a regional cohort of 196 patients with Crohn's disease diagnosed 1979-1987. The immediate outcome after 30 days, and the prolonged outcome 30 days after treatment had stopped, are described. In all 109 patients treatment was analysed. Complete remission was obtained in 48%, partial remission in 32%, and no response in 20% within 30 days of treatment. Among primary responders (complete and partial remission), 55% remained in prolonged response after treatment had finished, while 45% relapsed or could not be withdrawn from treatment within one year. Localisation of disease, age, sex or clinical symptoms did not significantly correlate with outcome, which can be summarised as prolonged steroid response in 44%, steroid dependency in 36%, and steroid resistant in 20% of the patients.

AB - The outcome of the first steroid treatment course was prospectively studied in a regional cohort of 196 patients with Crohn's disease diagnosed 1979-1987. The immediate outcome after 30 days, and the prolonged outcome 30 days after treatment had stopped, are described. In all 109 patients treatment was analysed. Complete remission was obtained in 48%, partial remission in 32%, and no response in 20% within 30 days of treatment. Among primary responders (complete and partial remission), 55% remained in prolonged response after treatment had finished, while 45% relapsed or could not be withdrawn from treatment within one year. Localisation of disease, age, sex or clinical symptoms did not significantly correlate with outcome, which can be summarised as prolonged steroid response in 44%, steroid dependency in 36%, and steroid resistant in 20% of the patients.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Child

KW - Cohort Studies

KW - Crohn Disease/drug therapy

KW - Drug Resistance

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Prednisolone/therapeutic use

KW - Prospective Studies

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1136/gut.35.3.360

DO - 10.1136/gut.35.3.360

M3 - Journal article

C2 - 8150347

SN - 0017-5749

VL - 35

SP - 360

EP - 362

JO - Gut

JF - Gut

IS - 3

ER -

Frequency of glucocorticoid resistance and dependency in Crohn's disease

Abstract

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