Frequency of Electrocardiographic Abnormalities in Patients With Psoriasis

Peter Riis Hansen; Christian Rimer Juhl; Jonas Lynggaard Isaksen; Gregor Borut Jemec; Christina Ellervik; Jørgen Kim Kanters

doi:10.1016/j.amjcard.2017.12.045

Frequency of Electrocardiographic Abnormalities in Patients With Psoriasis

Peter Riis Hansen, Christian Rimer Juhl, Jonas Lynggaard Isaksen, Gregor Borut Jemec, Christina Ellervik, Jørgen Kim Kanters

3 Citationer (Scopus)

Abstract

Psoriasis is a chronic inflammatory disease associated with cardiovascular disease, for example, myocardial infarction, stroke, cardiovascular death, and arrhythmias. The resting electrocardiogram may carry prognostic information, but limited evidence is available of electrocardiographic findings in subjects with psoriasis. The electrocardiographic results were compared between 1,131 subjects with self-reported psoriasis and 18,397 controls participating in the Danish General Suburban Population Study (GESUS). The mean heart rate was marginally increased in patients with psoriasis (66 ± 11 vs 65 ± 11 beats/min, p = 0.007), but not after adjustment for smoking and body mass index. All other examined electrocardiographic variables, including QT interval corrected for heart rate with the Fridericia formula, PR interval, QRS duration, R axis, P-wave duration in lead V1, P-terminal force, J point elevation in lead V1, electrocardiographic criteria for left ventricular hypertrophy, electrocardiographic signs of previous myocardial infarction, and premature ventricular or supraventricular complexes, respectively, were comparable between the 2 groups. In conclusion, psoriasis was associated with a marginal increase in resting heart rate, which was driven by smoking and increased body mass index. All other examined electrocardiographic variables were similar between the 2 groups. The results suggest that psoriasis per se is not associated with significant abnormalities of the electrocardiogram.

Originalsprog	Engelsk
Tidsskrift	American Journal of Cardiology
Vol/bind	121
Udgave nummer	8
Sider (fra-til)	1004-1007
ISSN	0002-9149
DOI	https://doi.org/10.1016/j.amjcard.2017.12.045
Status	Udgivet - 15 apr. 2018

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@article{9fd8b66234d847f792210e4b6644cee5,

title = "Frequency of Electrocardiographic Abnormalities in Patients With Psoriasis",

abstract = "Psoriasis is a chronic inflammatory disease associated with cardiovascular disease, for example, myocardial infarction, stroke, cardiovascular death, and arrhythmias. The resting electrocardiogram may carry prognostic information, but limited evidence is available of electrocardiographic findings in subjects with psoriasis. The electrocardiographic results were compared between 1,131 subjects with self-reported psoriasis and 18,397 controls participating in the Danish General Suburban Population Study (GESUS). The mean heart rate was marginally increased in patients with psoriasis (66 ± 11 vs 65 ± 11 beats/min, p = 0.007), but not after adjustment for smoking and body mass index. All other examined electrocardiographic variables, including QT interval corrected for heart rate with the Fridericia formula, PR interval, QRS duration, R axis, P-wave duration in lead V1, P-terminal force, J point elevation in lead V1, electrocardiographic criteria for left ventricular hypertrophy, electrocardiographic signs of previous myocardial infarction, and premature ventricular or supraventricular complexes, respectively, were comparable between the 2 groups. In conclusion, psoriasis was associated with a marginal increase in resting heart rate, which was driven by smoking and increased body mass index. All other examined electrocardiographic variables were similar between the 2 groups. The results suggest that psoriasis per se is not associated with significant abnormalities of the electrocardiogram.",

author = "Hansen, {Peter Riis} and Juhl, {Christian Rimer} and Isaksen, {Jonas Lynggaard} and Jemec, {Gregor Borut} and Christina Ellervik and Kanters, {J{\o}rgen Kim}",

year = "2018",

month = apr,

day = "15",

doi = "10.1016/j.amjcard.2017.12.045",

language = "English",

volume = "121",

pages = "1004--1007",

journal = "Am. J. Cardiol.",

issn = "0002-9149",

publisher = "Elsevier",

number = "8",

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TY - JOUR

T1 - Frequency of Electrocardiographic Abnormalities in Patients With Psoriasis

AU - Hansen, Peter Riis

AU - Juhl, Christian Rimer

AU - Isaksen, Jonas Lynggaard

AU - Jemec, Gregor Borut

AU - Ellervik, Christina

AU - Kanters, Jørgen Kim

PY - 2018/4/15

Y1 - 2018/4/15

N2 - Psoriasis is a chronic inflammatory disease associated with cardiovascular disease, for example, myocardial infarction, stroke, cardiovascular death, and arrhythmias. The resting electrocardiogram may carry prognostic information, but limited evidence is available of electrocardiographic findings in subjects with psoriasis. The electrocardiographic results were compared between 1,131 subjects with self-reported psoriasis and 18,397 controls participating in the Danish General Suburban Population Study (GESUS). The mean heart rate was marginally increased in patients with psoriasis (66 ± 11 vs 65 ± 11 beats/min, p = 0.007), but not after adjustment for smoking and body mass index. All other examined electrocardiographic variables, including QT interval corrected for heart rate with the Fridericia formula, PR interval, QRS duration, R axis, P-wave duration in lead V1, P-terminal force, J point elevation in lead V1, electrocardiographic criteria for left ventricular hypertrophy, electrocardiographic signs of previous myocardial infarction, and premature ventricular or supraventricular complexes, respectively, were comparable between the 2 groups. In conclusion, psoriasis was associated with a marginal increase in resting heart rate, which was driven by smoking and increased body mass index. All other examined electrocardiographic variables were similar between the 2 groups. The results suggest that psoriasis per se is not associated with significant abnormalities of the electrocardiogram.

AB - Psoriasis is a chronic inflammatory disease associated with cardiovascular disease, for example, myocardial infarction, stroke, cardiovascular death, and arrhythmias. The resting electrocardiogram may carry prognostic information, but limited evidence is available of electrocardiographic findings in subjects with psoriasis. The electrocardiographic results were compared between 1,131 subjects with self-reported psoriasis and 18,397 controls participating in the Danish General Suburban Population Study (GESUS). The mean heart rate was marginally increased in patients with psoriasis (66 ± 11 vs 65 ± 11 beats/min, p = 0.007), but not after adjustment for smoking and body mass index. All other examined electrocardiographic variables, including QT interval corrected for heart rate with the Fridericia formula, PR interval, QRS duration, R axis, P-wave duration in lead V1, P-terminal force, J point elevation in lead V1, electrocardiographic criteria for left ventricular hypertrophy, electrocardiographic signs of previous myocardial infarction, and premature ventricular or supraventricular complexes, respectively, were comparable between the 2 groups. In conclusion, psoriasis was associated with a marginal increase in resting heart rate, which was driven by smoking and increased body mass index. All other examined electrocardiographic variables were similar between the 2 groups. The results suggest that psoriasis per se is not associated with significant abnormalities of the electrocardiogram.

U2 - 10.1016/j.amjcard.2017.12.045

DO - 10.1016/j.amjcard.2017.12.045

M3 - Journal article

C2 - 29454476

SN - 0002-9149

VL - 121

SP - 1004

EP - 1007

JO - Am. J. Cardiol.

JF - Am. J. Cardiol.

IS - 8

ER -

Frequency of Electrocardiographic Abnormalities in Patients With Psoriasis

Abstract

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