Frequency and impact of obstetric complications prior and subsequent to unexplained secondary recurrent miscarriage

H S Nielsen; R Steffensen; M Lund; L Egestad; L H Mortensen; Anne-Marie Nybo Andersen; Ø Lidegaard; O B Christiansen

doi:10.1093/humrep/deq091

Frequency and impact of obstetric complications prior and subsequent to unexplained secondary recurrent miscarriage

H S Nielsen, R Steffensen, M Lund, L Egestad, L H Mortensen, Anne-Marie Nybo Andersen, Ø Lidegaard, O B Christiansen

45 Citationer (Scopus)

Abstract

Background The chance of a live birth after a diagnosis of secondary recurrent miscarriage (SRM) is reduced in patients who, prior to the miscarriages, gave birth to a boy and carry HLA class II alleles that efficiently present male-specific (H-Y) antigens to the immune system. Information about obstetric complications in births prior and subsequent to the SRM diagnosis is limited. The relations between maternal carriage of H-Y-restricting HLA, fetal sex, obstetric complications and prognosis are unknown. Methods Women with unexplained SRM referred to the Danish Recurrent Miscarriage Clinic between 1986 and 2006 (n = 358) were included; 213 gave birth after the diagnosis. Controls, retrieved from the Danish National Birth Registry, were all women with singleton birth of parity 0, 1982-2005 (n = 608 068) and parity 1, 1986-2008 (n = 510 264). Cross-linkage to the National Discharge Registry identified birth complication diagnoses related to the relevant births among patients and controls. Result SThe sex ratio was 1.49 in births prior to SRM and 0.76 in birth after SRM (P < 0.0001). For SRM patients with only late miscarriages (>10 weeks gestation), the corresponding sex ratios were 2.31 and 0.21. Compared with the control groups, obstetric complications were more frequent both before (39% versus 24% P ≤ 0.01) and after (19% versus 14%, P = 0.01) SRM diagnosis. Births were more frequently complicated when the child was a boy (44 versus 31, P = 0.02) before and a girl (24% versus 13%, P = 0.04) after SRM diagnosis. SRM patients with H-Y-restricting HLA class II alleles and a firstborn boy gave birth to children who weighed on average 381 g less (P = 0.006) and were born 0.9 weeks earlier (P = 0.06) and their births had more obstetric complications (P = 0.05) than patients with the same HLA alleles but a firstborn girl. Conclusions Obstetric complications, sex ratios in births prior and subsequent to SRM and maternal carriage of H-Y-restricting HLA class II alleles are associated parameters. Immune responses against fetal H-Y antigens initiated in the pregnancy prior to the SRM may play a causal role in SRM.

Originalsprog	Engelsk
Tidsskrift	Human Reproduction
Vol/bind	25
Udgave nummer	6
Sider (fra-til)	1543-52
Antal sider	10
ISSN	0268-1161
DOI	https://doi.org/10.1093/humrep/deq091
Status	Udgivet - jun. 2010

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10.1093/humrep/deq091

https://academic.oup.com/humrep/article-pdf/25/6/1543/9549711/deq091.pdf

Citationsformater

@article{643b26d54e5c49348d3da6dbb7ea95b1,

title = "Frequency and impact of obstetric complications prior and subsequent to unexplained secondary recurrent miscarriage",

abstract = "Background The chance of a live birth after a diagnosis of secondary recurrent miscarriage (SRM) is reduced in patients who, prior to the miscarriages, gave birth to a boy and carry HLA class II alleles that efficiently present male-specific (H-Y) antigens to the immune system. Information about obstetric complications in births prior and subsequent to the SRM diagnosis is limited. The relations between maternal carriage of H-Y-restricting HLA, fetal sex, obstetric complications and prognosis are unknown. Methods Women with unexplained SRM referred to the Danish Recurrent Miscarriage Clinic between 1986 and 2006 (n = 358) were included; 213 gave birth after the diagnosis. Controls, retrieved from the Danish National Birth Registry, were all women with singleton birth of parity 0, 1982-2005 (n = 608 068) and parity 1, 1986-2008 (n = 510 264). Cross-linkage to the National Discharge Registry identified birth complication diagnoses related to the relevant births among patients and controls. Result SThe sex ratio was 1.49 in births prior to SRM and 0.76 in birth after SRM (P < 0.0001). For SRM patients with only late miscarriages (>10 weeks gestation), the corresponding sex ratios were 2.31 and 0.21. Compared with the control groups, obstetric complications were more frequent both before (39% versus 24% P ≤ 0.01) and after (19% versus 14%, P = 0.01) SRM diagnosis. Births were more frequently complicated when the child was a boy (44 versus 31, P = 0.02) before and a girl (24% versus 13%, P = 0.04) after SRM diagnosis. SRM patients with H-Y-restricting HLA class II alleles and a firstborn boy gave birth to children who weighed on average 381 g less (P = 0.006) and were born 0.9 weeks earlier (P = 0.06) and their births had more obstetric complications (P = 0.05) than patients with the same HLA alleles but a firstborn girl. Conclusions Obstetric complications, sex ratios in births prior and subsequent to SRM and maternal carriage of H-Y-restricting HLA class II alleles are associated parameters. Immune responses against fetal H-Y antigens initiated in the pregnancy prior to the SRM may play a causal role in SRM.",

keywords = "Abortion, Habitual, Alleles, Denmark, Female, H-Y Antigen, HLA Antigens, Histocompatibility, Maternal-Fetal, Humans, Infant, Newborn, Live Birth, Male, Pregnancy, Pregnancy Complications, Registries, Risk Factors, Statistics, Nonparametric",

author = "Nielsen, {H S} and R Steffensen and M Lund and L Egestad and Mortensen, {L H} and Andersen, {Anne-Marie Nybo} and {\O} Lidegaard and Christiansen, {O B}",

year = "2010",

month = jun,

doi = "10.1093/humrep/deq091",

language = "English",

volume = "25",

pages = "1543--52",

journal = "Human Reproduction",

issn = "0268-1161",

publisher = "Oxford Academic",

number = "6",

}

TY - JOUR

T1 - Frequency and impact of obstetric complications prior and subsequent to unexplained secondary recurrent miscarriage

AU - Nielsen, H S

AU - Steffensen, R

AU - Lund, M

AU - Egestad, L

AU - Mortensen, L H

AU - Andersen, Anne-Marie Nybo

AU - Lidegaard, Ø

AU - Christiansen, O B

PY - 2010/6

Y1 - 2010/6

N2 - Background The chance of a live birth after a diagnosis of secondary recurrent miscarriage (SRM) is reduced in patients who, prior to the miscarriages, gave birth to a boy and carry HLA class II alleles that efficiently present male-specific (H-Y) antigens to the immune system. Information about obstetric complications in births prior and subsequent to the SRM diagnosis is limited. The relations between maternal carriage of H-Y-restricting HLA, fetal sex, obstetric complications and prognosis are unknown. Methods Women with unexplained SRM referred to the Danish Recurrent Miscarriage Clinic between 1986 and 2006 (n = 358) were included; 213 gave birth after the diagnosis. Controls, retrieved from the Danish National Birth Registry, were all women with singleton birth of parity 0, 1982-2005 (n = 608 068) and parity 1, 1986-2008 (n = 510 264). Cross-linkage to the National Discharge Registry identified birth complication diagnoses related to the relevant births among patients and controls. Result SThe sex ratio was 1.49 in births prior to SRM and 0.76 in birth after SRM (P < 0.0001). For SRM patients with only late miscarriages (>10 weeks gestation), the corresponding sex ratios were 2.31 and 0.21. Compared with the control groups, obstetric complications were more frequent both before (39% versus 24% P ≤ 0.01) and after (19% versus 14%, P = 0.01) SRM diagnosis. Births were more frequently complicated when the child was a boy (44 versus 31, P = 0.02) before and a girl (24% versus 13%, P = 0.04) after SRM diagnosis. SRM patients with H-Y-restricting HLA class II alleles and a firstborn boy gave birth to children who weighed on average 381 g less (P = 0.006) and were born 0.9 weeks earlier (P = 0.06) and their births had more obstetric complications (P = 0.05) than patients with the same HLA alleles but a firstborn girl. Conclusions Obstetric complications, sex ratios in births prior and subsequent to SRM and maternal carriage of H-Y-restricting HLA class II alleles are associated parameters. Immune responses against fetal H-Y antigens initiated in the pregnancy prior to the SRM may play a causal role in SRM.

AB - Background The chance of a live birth after a diagnosis of secondary recurrent miscarriage (SRM) is reduced in patients who, prior to the miscarriages, gave birth to a boy and carry HLA class II alleles that efficiently present male-specific (H-Y) antigens to the immune system. Information about obstetric complications in births prior and subsequent to the SRM diagnosis is limited. The relations between maternal carriage of H-Y-restricting HLA, fetal sex, obstetric complications and prognosis are unknown. Methods Women with unexplained SRM referred to the Danish Recurrent Miscarriage Clinic between 1986 and 2006 (n = 358) were included; 213 gave birth after the diagnosis. Controls, retrieved from the Danish National Birth Registry, were all women with singleton birth of parity 0, 1982-2005 (n = 608 068) and parity 1, 1986-2008 (n = 510 264). Cross-linkage to the National Discharge Registry identified birth complication diagnoses related to the relevant births among patients and controls. Result SThe sex ratio was 1.49 in births prior to SRM and 0.76 in birth after SRM (P < 0.0001). For SRM patients with only late miscarriages (>10 weeks gestation), the corresponding sex ratios were 2.31 and 0.21. Compared with the control groups, obstetric complications were more frequent both before (39% versus 24% P ≤ 0.01) and after (19% versus 14%, P = 0.01) SRM diagnosis. Births were more frequently complicated when the child was a boy (44 versus 31, P = 0.02) before and a girl (24% versus 13%, P = 0.04) after SRM diagnosis. SRM patients with H-Y-restricting HLA class II alleles and a firstborn boy gave birth to children who weighed on average 381 g less (P = 0.006) and were born 0.9 weeks earlier (P = 0.06) and their births had more obstetric complications (P = 0.05) than patients with the same HLA alleles but a firstborn girl. Conclusions Obstetric complications, sex ratios in births prior and subsequent to SRM and maternal carriage of H-Y-restricting HLA class II alleles are associated parameters. Immune responses against fetal H-Y antigens initiated in the pregnancy prior to the SRM may play a causal role in SRM.

KW - Abortion, Habitual

KW - Alleles

KW - Denmark

KW - Female

KW - H-Y Antigen

KW - HLA Antigens

KW - Histocompatibility, Maternal-Fetal

KW - Humans

KW - Infant, Newborn

KW - Live Birth

KW - Male

KW - Pregnancy

KW - Pregnancy Complications

KW - Registries

KW - Risk Factors

KW - Statistics, Nonparametric

U2 - 10.1093/humrep/deq091

DO - 10.1093/humrep/deq091

M3 - Journal article

C2 - 20395221

SN - 0268-1161

VL - 25

SP - 1543

EP - 1552

JO - Human Reproduction

JF - Human Reproduction

IS - 6

ER -

Frequency and impact of obstetric complications prior and subsequent to unexplained secondary recurrent miscarriage

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