Football training in men with prostate cancer undergoing androgen deprivation therapy: activity profile and short-term skeletal and postural balance adaptations

Jacob Uth; Therese Hornstrup; Jesper F Christensen; Karl Bang Christensen; Niklas R Jørgensen; Eva Wulff Helge; Jakob Friis Schmidt; Klaus Brasso; Jørn Wulff Helge; Markus Due Jakobsen; Lars Louis Andersen; Mikael Rahbek Rørth; Julie Midtgaard; Peter Krustrup

doi:10.1007/s00421-015-3301-y

Football training in men with prostate cancer undergoing androgen deprivation therapy: activity profile and short-term skeletal and postural balance adaptations

Jacob Uth, Therese Hornstrup, Jesper F Christensen, Karl Bang Christensen, Niklas R Jørgensen, Eva Wulff Helge, Jakob Friis Schmidt, Klaus Brasso, Jørn Wulff Helge, Markus Due Jakobsen, Lars Louis Andersen, Mikael Rahbek Rørth, Julie Midtgaard, Peter Krustrup

31 Citationer (Scopus)

Abstract

Purpose: To investigate the activity profile of football training and its short-term effects on bone mass, bone turnover markers (BTMs) and postural balance in men with prostate cancer (PCa) undergoing androgen deprivation therapy (ADT). Methods: This was a randomised 12-week study in which men with PCa undergoing ADT were assigned to a football intervention group [FTG, n = 29, 67 ± 7 (±SD) years] training 2‒3 times per week for 45‒60 min or to a control group (n = 28, 66 ± 5 years). The activity profile was measured using a 5-Hz GPS. The outcomes were total body and leg bone mineral content (BMC) and density, BTMs and postural balance. Results: In the last part of the 12 weeks, FTG performed 194 ± 41 accelerations and 296 ± 65 decelerations at >0.6 m/s/s and covered a distance of 905 ± 297 m at speeds >6 km/h and 2646 ± 705 m per training session. Analysis of baseline-to-12-week change scores showed between-group differences in favour of FTG in total body BMC [26.4 g, 95 % confidence interval (CI): 5.8–46.9 g, p = 0.013], leg BMC (13.8 g, 95 % CI: 7.0‒20.5 g, p < 0.001) and markers of bone formation: P1NP (36.6 µg/L, 95 % CI: 10.4‒62.8 µg/L, p = 0.008) and osteocalcin (8.6 µg/L, 95 % CI: 3.3‒13.8 µg/L, p < 0.01). The number of decelerations correlated to the increase in leg BMC (r = 0.65, p = 0.012). No between-group differences were observed for the remaining outcomes. Conclusion: Football training involves numerous runs, accelerations and decelerations, which may be linked to marked increases in bone formation markers and preserved bone mass in middle-aged and elderly men with PCa undergoing ADT. Trial registration: ClinicalTrials.gov: NCT01711892.

Originalsprog	Engelsk
Tidsskrift	European Journal of Applied Physiology
Vol/bind	116
Udgave nummer	3
Sider (fra-til)	471-480
Antal sider	10
ISSN	1439-6319
DOI	https://doi.org/10.1007/s00421-015-3301-y
Status	Udgivet - 1 mar. 2016

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10.1007/s00421-015-3301-y

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Uth, J., Hornstrup, T., Christensen, J. F., Christensen, K. B., Jørgensen, N. R., Helge, E. W., Schmidt, J. F., Brasso, K., Helge, J. W., Jakobsen, M. D., Andersen, L. L., Rørth, M. R., Midtgaard, J., & Krustrup, P. (2016). Football training in men with prostate cancer undergoing androgen deprivation therapy: activity profile and short-term skeletal and postural balance adaptations. European Journal of Applied Physiology, 116(3), 471-480. https://doi.org/10.1007/s00421-015-3301-y

Football training in men with prostate cancer undergoing androgen deprivation therapy : activity profile and short-term skeletal and postural balance adaptations. / Uth, Jacob; Hornstrup, Therese; Christensen, Jesper F et al.

I: European Journal of Applied Physiology, Bind 116, Nr. 3, 01.03.2016, s. 471-480.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Uth, J, Hornstrup, T, Christensen, JF, Christensen, KB, Jørgensen, NR, Helge, EW, Schmidt, JF, Brasso, K , Helge, JW, Jakobsen, MD, Andersen, LL, Rørth, MR, Midtgaard, J & Krustrup, P 2016, 'Football training in men with prostate cancer undergoing androgen deprivation therapy: activity profile and short-term skeletal and postural balance adaptations', European Journal of Applied Physiology, bind 116, nr. 3, s. 471-480. https://doi.org/10.1007/s00421-015-3301-y

@article{53f3278eed354287bf6129a6df903291,

title = "Football training in men with prostate cancer undergoing androgen deprivation therapy: activity profile and short-term skeletal and postural balance adaptations",

abstract = "Purpose: To investigate the activity profile of football training and its short-term effects on bone mass, bone turnover markers (BTMs) and postural balance in men with prostate cancer (PCa) undergoing androgen deprivation therapy (ADT). Methods: This was a randomised 12-week study in which men with PCa undergoing ADT were assigned to a football intervention group [FTG, n = 29, 67 ± 7 (±SD) years] training 2‒3 times per week for 45‒60 min or to a control group (n = 28, 66 ± 5 years). The activity profile was measured using a 5-Hz GPS. The outcomes were total body and leg bone mineral content (BMC) and density, BTMs and postural balance. Results: In the last part of the 12 weeks, FTG performed 194 ± 41 accelerations and 296 ± 65 decelerations at >0.6 m/s/s and covered a distance of 905 ± 297 m at speeds >6 km/h and 2646 ± 705 m per training session. Analysis of baseline-to-12-week change scores showed between-group differences in favour of FTG in total body BMC [26.4 g, 95 % confidence interval (CI): 5.8–46.9 g, p = 0.013], leg BMC (13.8 g, 95 % CI: 7.0‒20.5 g, p < 0.001) and markers of bone formation: P1NP (36.6 µg/L, 95 % CI: 10.4‒62.8 µg/L, p = 0.008) and osteocalcin (8.6 µg/L, 95 % CI: 3.3‒13.8 µg/L, p < 0.01). The number of decelerations correlated to the increase in leg BMC (r = 0.65, p = 0.012). No between-group differences were observed for the remaining outcomes. Conclusion: Football training involves numerous runs, accelerations and decelerations, which may be linked to marked increases in bone formation markers and preserved bone mass in middle-aged and elderly men with PCa undergoing ADT. Trial registration: ClinicalTrials.gov: NCT01711892.",

author = "Jacob Uth and Therese Hornstrup and Christensen, {Jesper F} and Christensen, {Karl Bang} and J{\o}rgensen, {Niklas R} and Helge, {Eva Wulff} and Schmidt, {Jakob Friis} and Klaus Brasso and Helge, {J{\o}rn Wulff} and Jakobsen, {Markus Due} and Andersen, {Lars Louis} and R{\o}rth, {Mikael Rahbek} and Julie Midtgaard and Peter Krustrup",

note = "CURIS 2016 NEXS 059",

year = "2016",

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day = "1",

doi = "10.1007/s00421-015-3301-y",

language = "English",

volume = "116",

pages = "471--480",

journal = "European Journal of Applied Physiology",

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TY - JOUR

T1 - Football training in men with prostate cancer undergoing androgen deprivation therapy

T2 - activity profile and short-term skeletal and postural balance adaptations

AU - Uth, Jacob

AU - Hornstrup, Therese

AU - Christensen, Jesper F

AU - Christensen, Karl Bang

AU - Jørgensen, Niklas R

AU - Helge, Eva Wulff

AU - Schmidt, Jakob Friis

AU - Brasso, Klaus

AU - Helge, Jørn Wulff

AU - Jakobsen, Markus Due

AU - Andersen, Lars Louis

AU - Rørth, Mikael Rahbek

AU - Midtgaard, Julie

AU - Krustrup, Peter

N1 - CURIS 2016 NEXS 059

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Purpose: To investigate the activity profile of football training and its short-term effects on bone mass, bone turnover markers (BTMs) and postural balance in men with prostate cancer (PCa) undergoing androgen deprivation therapy (ADT). Methods: This was a randomised 12-week study in which men with PCa undergoing ADT were assigned to a football intervention group [FTG, n = 29, 67 ± 7 (±SD) years] training 2‒3 times per week for 45‒60 min or to a control group (n = 28, 66 ± 5 years). The activity profile was measured using a 5-Hz GPS. The outcomes were total body and leg bone mineral content (BMC) and density, BTMs and postural balance. Results: In the last part of the 12 weeks, FTG performed 194 ± 41 accelerations and 296 ± 65 decelerations at >0.6 m/s/s and covered a distance of 905 ± 297 m at speeds >6 km/h and 2646 ± 705 m per training session. Analysis of baseline-to-12-week change scores showed between-group differences in favour of FTG in total body BMC [26.4 g, 95 % confidence interval (CI): 5.8–46.9 g, p = 0.013], leg BMC (13.8 g, 95 % CI: 7.0‒20.5 g, p < 0.001) and markers of bone formation: P1NP (36.6 µg/L, 95 % CI: 10.4‒62.8 µg/L, p = 0.008) and osteocalcin (8.6 µg/L, 95 % CI: 3.3‒13.8 µg/L, p < 0.01). The number of decelerations correlated to the increase in leg BMC (r = 0.65, p = 0.012). No between-group differences were observed for the remaining outcomes. Conclusion: Football training involves numerous runs, accelerations and decelerations, which may be linked to marked increases in bone formation markers and preserved bone mass in middle-aged and elderly men with PCa undergoing ADT. Trial registration: ClinicalTrials.gov: NCT01711892.

AB - Purpose: To investigate the activity profile of football training and its short-term effects on bone mass, bone turnover markers (BTMs) and postural balance in men with prostate cancer (PCa) undergoing androgen deprivation therapy (ADT). Methods: This was a randomised 12-week study in which men with PCa undergoing ADT were assigned to a football intervention group [FTG, n = 29, 67 ± 7 (±SD) years] training 2‒3 times per week for 45‒60 min or to a control group (n = 28, 66 ± 5 years). The activity profile was measured using a 5-Hz GPS. The outcomes were total body and leg bone mineral content (BMC) and density, BTMs and postural balance. Results: In the last part of the 12 weeks, FTG performed 194 ± 41 accelerations and 296 ± 65 decelerations at >0.6 m/s/s and covered a distance of 905 ± 297 m at speeds >6 km/h and 2646 ± 705 m per training session. Analysis of baseline-to-12-week change scores showed between-group differences in favour of FTG in total body BMC [26.4 g, 95 % confidence interval (CI): 5.8–46.9 g, p = 0.013], leg BMC (13.8 g, 95 % CI: 7.0‒20.5 g, p < 0.001) and markers of bone formation: P1NP (36.6 µg/L, 95 % CI: 10.4‒62.8 µg/L, p = 0.008) and osteocalcin (8.6 µg/L, 95 % CI: 3.3‒13.8 µg/L, p < 0.01). The number of decelerations correlated to the increase in leg BMC (r = 0.65, p = 0.012). No between-group differences were observed for the remaining outcomes. Conclusion: Football training involves numerous runs, accelerations and decelerations, which may be linked to marked increases in bone formation markers and preserved bone mass in middle-aged and elderly men with PCa undergoing ADT. Trial registration: ClinicalTrials.gov: NCT01711892.

U2 - 10.1007/s00421-015-3301-y

DO - 10.1007/s00421-015-3301-y

M3 - Journal article

C2 - 26620651

SN - 1439-6319

VL - 116

SP - 471

EP - 480

JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

IS - 3

ER -

Football training in men with prostate cancer undergoing androgen deprivation therapy: activity profile and short-term skeletal and postural balance adaptations

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