Football training improves lean body mass in men with prostate cancer undergoing androgen deprivation therapy

TY - JOUR

T1 - Football training improves lean body mass in men with prostate cancer undergoing androgen deprivation therapy

AU - Uth, J

AU - Hornstrup, Therese

AU - Schmidt, Jakob Friis

AU - Christensen, J F

AU - Frandsen, C

AU - Christensen, Karl Bang

AU - Helge, Eva Wulff

AU - Brasso, Klaus

AU - Rørth, Mikael Rahbek

AU - Midtgaard, Julie

AU - Krustrup, Peter

N1 - CURIS 2014 NEXS 188

PY - 2014/8

Y1 - 2014/8

N2 - Androgen deprivation therapy (ADT) remains a cornerstone in the management of patients with prostate cancer (PCa) despite adverse effects on body composition and functional parameters. We compared the effects of football training with standard care in PCa patients managed with ADT (>6 months). Fifty-seven men aged 67 (range: 43-74) were randomly assigned to a football group (FG, n=29) or a usual care control group (CON, n=28). The primary outcome was change in lean body mass (LBM) assessed by dual-energy X-ray absorptiometry scanning. Secondary outcomes included changes in knee-extensor muscle strength (one repetition maximum), fat percentage, and maximal oxygen uptake (VO2max). Mean heart rate during training was 137.7 (standard deviation 13.7) bpm or 84.6 (3.9)% HRmax. In FG, LBM increased by 0.5kg [95% confidence interval (CI) 0.1-0.9; P=0.02] with no change in CON (mean group difference 0.7kg; 95% CI 0.1-1.2; P=0.02). Also, muscle strength increased in FG (8.9kg; 95% CI 6.0-11.8; P<0.001) with no change in CON (mean group difference 6.7kg; 95% CI 2.8-10.7; P<0.001). In FG, VO2max increased (1.0mL/kg/min; 95% CI 0.2-1.9; P=0.02) and fat percentage tended to decrease (0.7%; 95%CI 1.3-0.0; P=0.06), but these changes were not significantly different from CON. In conclusion, football training over 12 weeks improved LBM and muscle strength compared with usual care in men with prostate cancer receiving ADT.

AB - Androgen deprivation therapy (ADT) remains a cornerstone in the management of patients with prostate cancer (PCa) despite adverse effects on body composition and functional parameters. We compared the effects of football training with standard care in PCa patients managed with ADT (>6 months). Fifty-seven men aged 67 (range: 43-74) were randomly assigned to a football group (FG, n=29) or a usual care control group (CON, n=28). The primary outcome was change in lean body mass (LBM) assessed by dual-energy X-ray absorptiometry scanning. Secondary outcomes included changes in knee-extensor muscle strength (one repetition maximum), fat percentage, and maximal oxygen uptake (VO2max). Mean heart rate during training was 137.7 (standard deviation 13.7) bpm or 84.6 (3.9)% HRmax. In FG, LBM increased by 0.5kg [95% confidence interval (CI) 0.1-0.9; P=0.02] with no change in CON (mean group difference 0.7kg; 95% CI 0.1-1.2; P=0.02). Also, muscle strength increased in FG (8.9kg; 95% CI 6.0-11.8; P<0.001) with no change in CON (mean group difference 6.7kg; 95% CI 2.8-10.7; P<0.001). In FG, VO2max increased (1.0mL/kg/min; 95% CI 0.2-1.9; P=0.02) and fat percentage tended to decrease (0.7%; 95%CI 1.3-0.0; P=0.06), but these changes were not significantly different from CON. In conclusion, football training over 12 weeks improved LBM and muscle strength compared with usual care in men with prostate cancer receiving ADT.

U2 - 10.1111/sms.12260

DO - 10.1111/sms.12260

M3 - Journal article

C2 - 24944134

SN - 0905-7188

VL - 24

SP - 105

EP - 112

JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

IS - Suppl. 1

ER -