TY - JOUR
T1 - Fluid therapy for the surgical patient
AU - Brandstrup, Birgitte
PY - 2006
Y1 - 2006
N2 - Perioperative fluid therapy is the subject of much controversy, and the results of the clinical trials investigating the effect of fluid therapy on outcome of surgery seem contradictory. The aim of this chapter is to review the evidence behind current standard fluid therapy, and to critically analyse the trials examining the effect of fluid therapy on outcome of surgery. The following conclusions are reached: current standard fluid therapy is not at all evidence-based; the evaporative loss from the abdominal cavity is highly overestimated; the non-anatomical third space loss is based on flawed methodology and most probably does not exist; the fluid volume accumulated in traumatized tissue is very small; and volume preloading of neuroaxial blockade is not effective and may cause postoperative fluid overload. The trials of 'goal-directed fluid therapy' aiming at maximal stroke volume and the trials of 'restricted intravenous fluid therapy' are also critically evaluated. The difference in results may be caused by a lax attitude towards 'standard fluid therapy' in the trials of goal-directed fluid therapy, resulting in the testing of various 'standard fluid regimens' versus 'even more fluid'. Without evidence of the existence of a non-anatomical third space loss and ineffectiveness of preloading of neuroaxial blockade, 'restricted intravenous fluid therapy' is not 'restricted', but rather avoids fluid overload by replacing only the fluid actually lost during surgery. The trials of different fluid volumes administered during outpatient surgery confirm that replacement of fluid lost improves outcome. Based on current evidence, the principles of 'restricted intravenous fluid therapy' are recommended: fluid lost should be replaced and fluid overload should be avoided.
AB - Perioperative fluid therapy is the subject of much controversy, and the results of the clinical trials investigating the effect of fluid therapy on outcome of surgery seem contradictory. The aim of this chapter is to review the evidence behind current standard fluid therapy, and to critically analyse the trials examining the effect of fluid therapy on outcome of surgery. The following conclusions are reached: current standard fluid therapy is not at all evidence-based; the evaporative loss from the abdominal cavity is highly overestimated; the non-anatomical third space loss is based on flawed methodology and most probably does not exist; the fluid volume accumulated in traumatized tissue is very small; and volume preloading of neuroaxial blockade is not effective and may cause postoperative fluid overload. The trials of 'goal-directed fluid therapy' aiming at maximal stroke volume and the trials of 'restricted intravenous fluid therapy' are also critically evaluated. The difference in results may be caused by a lax attitude towards 'standard fluid therapy' in the trials of goal-directed fluid therapy, resulting in the testing of various 'standard fluid regimens' versus 'even more fluid'. Without evidence of the existence of a non-anatomical third space loss and ineffectiveness of preloading of neuroaxial blockade, 'restricted intravenous fluid therapy' is not 'restricted', but rather avoids fluid overload by replacing only the fluid actually lost during surgery. The trials of different fluid volumes administered during outpatient surgery confirm that replacement of fluid lost improves outcome. Based on current evidence, the principles of 'restricted intravenous fluid therapy' are recommended: fluid lost should be replaced and fluid overload should be avoided.
KW - Evidence-Based Medicine
KW - Fluid Therapy/trends
KW - Humans
KW - Outcome Assessment (Health Care)
KW - Perioperative Care/trends
KW - Postoperative Complications/etiology
KW - Surgical Procedures, Operative/adverse effects
U2 - 10.1016/j.bpa.2005.10.007
DO - 10.1016/j.bpa.2005.10.007
M3 - Review
C2 - 16850777
SN - 1521-6896
VL - 20
SP - 265
EP - 283
JO - Best Practice & Research: Clinical Anaesthesiology
JF - Best Practice & Research: Clinical Anaesthesiology
IS - 2
ER -