Flow injection on-line dilution for multi-element determination in human urine with detection by inductively coupled plasma mass spectrometry

J.H. Wang; E.H. Hansen; Bente Gammelgaard

Flow injection on-line dilution for multi-element determination in human urine with detection by inductively coupled plasma mass spectrometry

J.H. Wang, E.H. Hansen, Bente Gammelgaard

63 Citationer (Scopus)

Abstract

A simple flow injection on-line dilution procedure with detection by inductively coupled plasma mass spectrometry (ICP-MS) was developed for the determination of copper, zinc, arsenic, lead, selenium, nickel and molybdenum in human urine. Matrix effects were minimized by employing a dilution factor of 16.5 with on-line standard addition, and Rh-103 was used as internal standard to compensate for signal fluctuation. The procedure was validated by the analysis of two standard reference materials SRM 2670 (NIST) and Seronorm (TM) Trace Elements in Urine. Recovery experiments were pet-formed by spiking the reference materials as well as artificial urine. The detection limits (mug l(-1)) were 0.12, 0.96, 0.30, 0.09, 0.45, 0.08, 0.09, and the precisions (RSD,%) were 2.6, 2.3, 3.0, 3.7, 3.7, 4.9, 2.8 for Cu, Zn, As, Pb, Se, Ni and Mo, respectively. The procedure was applied to the analysis of 41 human urine samples. No correlations between the concentrations of the elements were observed. (C) 2001 Elsevier Science B.V. All rights reserved

Originalsprog	Udefineret/Ukendt
Tidsskrift	Talanta
Vol/bind	55
Udgave nummer	1
Sider (fra-til)	117-126
Antal sider	10
ISSN	0039-9140
Status	Udgivet - 2001

Citationsformater

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title = "Flow injection on-line dilution for multi-element determination in human urine with detection by inductively coupled plasma mass spectrometry",

abstract = "A simple flow injection on-line dilution procedure with detection by inductively coupled plasma mass spectrometry (ICP-MS) was developed for the determination of copper, zinc, arsenic, lead, selenium, nickel and molybdenum in human urine. Matrix effects were minimized by employing a dilution factor of 16.5 with on-line standard addition, and Rh-103 was used as internal standard to compensate for signal fluctuation. The procedure was validated by the analysis of two standard reference materials SRM 2670 (NIST) and Seronorm (TM) Trace Elements in Urine. Recovery experiments were pet-formed by spiking the reference materials as well as artificial urine. The detection limits (mug l(-1)) were 0.12, 0.96, 0.30, 0.09, 0.45, 0.08, 0.09, and the precisions (RSD,%) were 2.6, 2.3, 3.0, 3.7, 3.7, 4.9, 2.8 for Cu, Zn, As, Pb, Se, Ni and Mo, respectively. The procedure was applied to the analysis of 41 human urine samples. No correlations between the concentrations of the elements were observed. (C) 2001 Elsevier Science B.V. All rights reserved",

author = "J.H. Wang and E.H. Hansen and Bente Gammelgaard",

year = "2001",

language = "Udefineret/Ukendt",

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TY - JOUR

T1 - Flow injection on-line dilution for multi-element determination in human urine with detection by inductively coupled plasma mass spectrometry

AU - Wang, J.H.

AU - Hansen, E.H.

AU - Gammelgaard, Bente

PY - 2001

Y1 - 2001

N2 - A simple flow injection on-line dilution procedure with detection by inductively coupled plasma mass spectrometry (ICP-MS) was developed for the determination of copper, zinc, arsenic, lead, selenium, nickel and molybdenum in human urine. Matrix effects were minimized by employing a dilution factor of 16.5 with on-line standard addition, and Rh-103 was used as internal standard to compensate for signal fluctuation. The procedure was validated by the analysis of two standard reference materials SRM 2670 (NIST) and Seronorm (TM) Trace Elements in Urine. Recovery experiments were pet-formed by spiking the reference materials as well as artificial urine. The detection limits (mug l(-1)) were 0.12, 0.96, 0.30, 0.09, 0.45, 0.08, 0.09, and the precisions (RSD,%) were 2.6, 2.3, 3.0, 3.7, 3.7, 4.9, 2.8 for Cu, Zn, As, Pb, Se, Ni and Mo, respectively. The procedure was applied to the analysis of 41 human urine samples. No correlations between the concentrations of the elements were observed. (C) 2001 Elsevier Science B.V. All rights reserved

AB - A simple flow injection on-line dilution procedure with detection by inductively coupled plasma mass spectrometry (ICP-MS) was developed for the determination of copper, zinc, arsenic, lead, selenium, nickel and molybdenum in human urine. Matrix effects were minimized by employing a dilution factor of 16.5 with on-line standard addition, and Rh-103 was used as internal standard to compensate for signal fluctuation. The procedure was validated by the analysis of two standard reference materials SRM 2670 (NIST) and Seronorm (TM) Trace Elements in Urine. Recovery experiments were pet-formed by spiking the reference materials as well as artificial urine. The detection limits (mug l(-1)) were 0.12, 0.96, 0.30, 0.09, 0.45, 0.08, 0.09, and the precisions (RSD,%) were 2.6, 2.3, 3.0, 3.7, 3.7, 4.9, 2.8 for Cu, Zn, As, Pb, Se, Ni and Mo, respectively. The procedure was applied to the analysis of 41 human urine samples. No correlations between the concentrations of the elements were observed. (C) 2001 Elsevier Science B.V. All rights reserved

M3 - Tidsskriftartikel

SN - 0039-9140

VL - 55

SP - 117

EP - 126

JO - Talanta

JF - Talanta

IS - 1

ER -