Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents

TY - JOUR

T1 - Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents

AU - Ghanima, W.

AU - Bussel, J.B.

AU - Junker, P.

AU - Hasselbalch, H.C.

AU - Gudbrandsdottir, S.

AU - Boiocchi, L.

AU - Geyer, J.T.

AU - Orazi, A.

AU - Feng, X.

PY - 2011/10/1

Y1 - 2011/10/1

N2 - This study assessed the grade of bone marrow (BM) fibrosis and its association with a seromarker for collagen-III formation and fibrosis-related cytokines in 25 immune thrombocytopenia (ITP) patients treated with thrombopoietin receptor agonists (Tpo-RA) who had at least one BM biopsy. Assessment of 8 pre- and on-treatment BM biopsies revealed statistically significant increases in reticulin. Reticulin in biopsies performed after a median of 1·4years of treatment was graded: MF-0 in 3 (12%), MF-1 in 19 (76%), MF-2 in 2 (8%) and MF-3 in 1 (4%). No cytogenetic or flow-cytometric abnormalities were detected. Median pretreatment Procollagen III N-propeptide (PIIINP) (6·6μg/l) was significantly higher than on-treatment levels (5·6μg/l); both were higher than controls (3·4μg/l; P

AB - This study assessed the grade of bone marrow (BM) fibrosis and its association with a seromarker for collagen-III formation and fibrosis-related cytokines in 25 immune thrombocytopenia (ITP) patients treated with thrombopoietin receptor agonists (Tpo-RA) who had at least one BM biopsy. Assessment of 8 pre- and on-treatment BM biopsies revealed statistically significant increases in reticulin. Reticulin in biopsies performed after a median of 1·4years of treatment was graded: MF-0 in 3 (12%), MF-1 in 19 (76%), MF-2 in 2 (8%) and MF-3 in 1 (4%). No cytogenetic or flow-cytometric abnormalities were detected. Median pretreatment Procollagen III N-propeptide (PIIINP) (6·6μg/l) was significantly higher than on-treatment levels (5·6μg/l); both were higher than controls (3·4μg/l; P

UR - http://www.scopus.com/inward/record.url?scp=80053572889&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2141.2011.08845.x

DO - 10.1111/j.1365-2141.2011.08845.x

M3 - Journal article

C2 - 21902682

AN - SCOPUS:80053572889

SN - 0007-1048

VL - 155

SP - 248

EP - 255

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 2

ER -