TY - JOUR
T1 - Fibrillin-1 genotype and risk of prevalent hypertension
T2 - A study in two independent populations
AU - Jeppesen, Jørgen
AU - Berg, Nikolaj D
AU - Torp-Pedersen, Christian
AU - Hansen, Tine W
AU - Linneberg, Allan
AU - Fenger, Mogens
AU - Berg, Nikolaj D
PY - 2012/10
Y1 - 2012/10
N2 - Objective. Mutations in the fibrillin-1 gene are the cause of Marfan syndrome. We wanted to investigate the relationship between a mutation in this gene and risk of prevalent hypertension. Methods. In a cross-sectional study, the effect of a G-A substitution in intron 27 in the fibrillin-1 gene (rs11856553) on risk of prevalent hypertension was studied in two large population-based studies: the Health 2006 study, consisting of 3193 women and men, age 18-69 years, and the MONICA10 study, consisting of 2408 women and men, age 41-72 years. In 1646 MONICA10 participants, blood pressure (BP) was also measured by 24-h ambulatory recordings. Results. Among the 3193 Health 2006 participants 23 had the G-A variant, and among the 2408 MONICA10 participants 18 had the G-A variant. In Health 2006, the odds ratio estimate (95% confidence intervals) for the G-A variant for risk of hypertension, defined as systolic (S) BP =¿140 mmHg or diastolic (D) BP =¿90 mmHg or on antihypertensive medicine, was 2.67 (1.14-6.18), p =¿0.022. The corresponding figure for moderate to severe hypertension, defined as SBP =¿160 mmHg or DBP =¿100 mmHg, was 9.68 (4.24-22.12), p
AB - Objective. Mutations in the fibrillin-1 gene are the cause of Marfan syndrome. We wanted to investigate the relationship between a mutation in this gene and risk of prevalent hypertension. Methods. In a cross-sectional study, the effect of a G-A substitution in intron 27 in the fibrillin-1 gene (rs11856553) on risk of prevalent hypertension was studied in two large population-based studies: the Health 2006 study, consisting of 3193 women and men, age 18-69 years, and the MONICA10 study, consisting of 2408 women and men, age 41-72 years. In 1646 MONICA10 participants, blood pressure (BP) was also measured by 24-h ambulatory recordings. Results. Among the 3193 Health 2006 participants 23 had the G-A variant, and among the 2408 MONICA10 participants 18 had the G-A variant. In Health 2006, the odds ratio estimate (95% confidence intervals) for the G-A variant for risk of hypertension, defined as systolic (S) BP =¿140 mmHg or diastolic (D) BP =¿90 mmHg or on antihypertensive medicine, was 2.67 (1.14-6.18), p =¿0.022. The corresponding figure for moderate to severe hypertension, defined as SBP =¿160 mmHg or DBP =¿100 mmHg, was 9.68 (4.24-22.12), p
U2 - 10.3109/08037051.2012.680750
DO - 10.3109/08037051.2012.680750
M3 - Journal article
C2 - 22545955
SN - 0803-7051
VL - 21
SP - 273
EP - 280
JO - Blood Pressure
JF - Blood Pressure
IS - 5
ER -