Fansidar resistant falciparum malaria acquired in South East Asia

TY - JOUR

T1 - Fansidar resistant falciparum malaria acquired in South East Asia

AU - Black, F.

AU - Bygbjerg, I.

AU - Effersoe, P.

AU - Gomme, Grethe

AU - Jepsen, S.

AU - Axelgaard Jensen, G.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - A case of Plasmodium falciparum malaria resistant to Fansidar (sulphadoxine plus pyrimethamine) at a level corresponding to R III and resistant to chloroquine is reported. The infection was most certainly acquired in Malaysia, but diagnosed and treated in a non-malarious area. Normal resorption and elimination rates of the Fansidar components excludes cure failure due to abnormal drug fate in the host. P. falciparum parasites from the patient have been maintained in in vitro cultures. The patient was permanently cured with mefloquine.

AB - A case of Plasmodium falciparum malaria resistant to Fansidar (sulphadoxine plus pyrimethamine) at a level corresponding to R III and resistant to chloroquine is reported. The infection was most certainly acquired in Malaysia, but diagnosed and treated in a non-malarious area. Normal resorption and elimination rates of the Fansidar components excludes cure failure due to abnormal drug fate in the host. P. falciparum parasites from the patient have been maintained in in vitro cultures. The patient was permanently cured with mefloquine.

UR - http://www.scopus.com/inward/record.url?scp=0019776513&partnerID=8YFLogxK

U2 - 10.1016/0035-9203(81)90160-7

DO - 10.1016/0035-9203(81)90160-7

M3 - Letter

C2 - 7036431

AN - SCOPUS:0019776513

SN - 0035-9203

VL - 75

SP - 715

EP - 716

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 5

ER -