Familial Hemiplegic Migraine and Recurrent Episodes of Psychosis: A Case Report

TY - JOUR

T1 - Familial Hemiplegic Migraine and Recurrent Episodes of Psychosis

T2 - A Case Report

AU - LaBianca, Sonja

AU - Jensen, Rigmor

AU - van den Maagdenberg, Arn M J M

AU - Baandrup, Lone

AU - Bendtsen, Lars

N1 - © 2015 American Headache Society.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Familial hemiplegic migraine (FHM) is a rare autosomal dominant form of migraine with motor aura. We present a case report of a father and son with very similar attacks of hemiplegic migraine and recurrent episodes of accompanying psychoses. Previously, such episodes led to hospitalization and extended clinical examinations, which further worsened the psychoses. Since the episodes were recognized as related to the hemiplegic migraine, a treatment strategy combining sleep and sedation was initiated and progression onto psychosis was almost completely avoided in both father and son. Genetic analyses found no causal gene mutation in the three known FHM genes, suggesting that the phenotype is caused by a yet unidentified mutation.

AB - Familial hemiplegic migraine (FHM) is a rare autosomal dominant form of migraine with motor aura. We present a case report of a father and son with very similar attacks of hemiplegic migraine and recurrent episodes of accompanying psychoses. Previously, such episodes led to hospitalization and extended clinical examinations, which further worsened the psychoses. Since the episodes were recognized as related to the hemiplegic migraine, a treatment strategy combining sleep and sedation was initiated and progression onto psychosis was almost completely avoided in both father and son. Genetic analyses found no causal gene mutation in the three known FHM genes, suggesting that the phenotype is caused by a yet unidentified mutation.

U2 - 10.1111/head.12595

DO - 10.1111/head.12595

M3 - Letter

C2 - 26087244

SN - 0017-8748

VL - 55

SP - 1004

EP - 1007

JO - Headache

JF - Headache

IS - 7

ER -