Factors regulating fat oxidation in human skeletal muscle

Bente Kiens; Thomas Junker Alsted; Jacob Jeppesen

doi:10.1111/j.1467-789x.2011.00898.x

Factors regulating fat oxidation in human skeletal muscle

Bente Kiens, Thomas Junker Alsted, Jacob Jeppesen

25 Citationer (Scopus)

Abstract

In modern societies, oversupply of calories leads to obesity and chronic metabolic stress, which may lead to development of disease. Oversupply of calories is often associated with elevated plasma lipid concentrations and accumulation of lipids in skeletal muscle leading to decreased insulin sensitivity. Consequently, enhanced fat oxidation might be beneficial in counteracting lipid accumulation. Exercise is the most effective way to increase fat oxidation, because it increases metabolic rate. Lipid metabolism can also be altered by dietary manipulations. Thus, a fat rich diet leads to increased potential for fat oxidation by increasing the content of several of the proteins in the fat oxidative pathway. The regulation of both exercise and diet induced lipid oxidation will be discussed in this review.

Originalsprog	Engelsk
Tidsskrift	Obesity Reviews
Vol/bind	12
Udgave nummer	10
Sider (fra-til)	852-858
Antal sider	7
ISSN	1467-7881
DOI	https://doi.org/10.1111/j.1467-789x.2011.00898.x
Status	Udgivet - okt. 2011

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10.1111/j.1467-789x.2011.00898.x

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title = "Factors regulating fat oxidation in human skeletal muscle",

abstract = "In modern societies, oversupply of calories leads to obesity and chronic metabolic stress, which may lead to development of disease. Oversupply of calories is often associated with elevated plasma lipid concentrations and accumulation of lipids in skeletal muscle leading to decreased insulin sensitivity. Consequently, enhanced fat oxidation might be beneficial in counteracting lipid accumulation. Exercise is the most effective way to increase fat oxidation, because it increases metabolic rate. Lipid metabolism can also be altered by dietary manipulations. Thus, a fat rich diet leads to increased potential for fat oxidation by increasing the content of several of the proteins in the fat oxidative pathway. The regulation of both exercise and diet induced lipid oxidation will be discussed in this review.",

author = "Bente Kiens and Alsted, {Thomas Junker} and Jacob Jeppesen",

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AU - Kiens, Bente

AU - Alsted, Thomas Junker

AU - Jeppesen, Jacob

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PY - 2011/10

Y1 - 2011/10

N2 - In modern societies, oversupply of calories leads to obesity and chronic metabolic stress, which may lead to development of disease. Oversupply of calories is often associated with elevated plasma lipid concentrations and accumulation of lipids in skeletal muscle leading to decreased insulin sensitivity. Consequently, enhanced fat oxidation might be beneficial in counteracting lipid accumulation. Exercise is the most effective way to increase fat oxidation, because it increases metabolic rate. Lipid metabolism can also be altered by dietary manipulations. Thus, a fat rich diet leads to increased potential for fat oxidation by increasing the content of several of the proteins in the fat oxidative pathway. The regulation of both exercise and diet induced lipid oxidation will be discussed in this review.

AB - In modern societies, oversupply of calories leads to obesity and chronic metabolic stress, which may lead to development of disease. Oversupply of calories is often associated with elevated plasma lipid concentrations and accumulation of lipids in skeletal muscle leading to decreased insulin sensitivity. Consequently, enhanced fat oxidation might be beneficial in counteracting lipid accumulation. Exercise is the most effective way to increase fat oxidation, because it increases metabolic rate. Lipid metabolism can also be altered by dietary manipulations. Thus, a fat rich diet leads to increased potential for fat oxidation by increasing the content of several of the proteins in the fat oxidative pathway. The regulation of both exercise and diet induced lipid oxidation will be discussed in this review.

U2 - 10.1111/j.1467-789x.2011.00898.x

DO - 10.1111/j.1467-789x.2011.00898.x

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JO - Obesity Reviews

JF - Obesity Reviews

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ER -

Factors regulating fat oxidation in human skeletal muscle

Abstract

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