Factors associated with long-term mortality in acute pancreatitis

TY - JOUR

T1 - Factors associated with long-term mortality in acute pancreatitis

AU - Nøjgaard, Camilla

AU - Matzen, Peter

AU - Bendtsen, Flemming

AU - Andersen, Jens Rikardt

AU - Christensen, Erik

AU - Becker, Ulrik

PY - 2011/4

Y1 - 2011/4

N2 - Background and aims. Knowledge of the long-term prognosis of acute pancreatitis (AP) is limited. The aims were to investigate: (1) prognostic factors associated with long-term mortality in patients with AP; (2) whether or not the level of serum (S-)amylase at admission had an impact on the prognosis; (3) causes of death in these patients. Methods. During 1977-1982, patients who were admitted to the five main hospitals in Copenhagen with a diagnosis of AP or chronic pancreatitis (CP) were included in a prospective cohort, the Copenhagen Pancreatitis Study (CPS); in 2008, they were followed up by linkage to the Danish Registries. The analyzed subcohort consisted of 352 patients with probable AP (n = 54) or definite AP (n = 298). Results. Multivariate Cox regression analysis showed that significant factors associated with mortality were age, alcohol, and diabetes, whereas female gender, co-living and employment were associated with better survival. The S-amylase level had no impact on mortality. The most frequent causes of death were cardiovascular diseases, digestive diseases, and malignancies. Conclusions. Age, alcohol and diabetes had a significant impact on survival whereas the S-amylase level did not.

AB - Background and aims. Knowledge of the long-term prognosis of acute pancreatitis (AP) is limited. The aims were to investigate: (1) prognostic factors associated with long-term mortality in patients with AP; (2) whether or not the level of serum (S-)amylase at admission had an impact on the prognosis; (3) causes of death in these patients. Methods. During 1977-1982, patients who were admitted to the five main hospitals in Copenhagen with a diagnosis of AP or chronic pancreatitis (CP) were included in a prospective cohort, the Copenhagen Pancreatitis Study (CPS); in 2008, they were followed up by linkage to the Danish Registries. The analyzed subcohort consisted of 352 patients with probable AP (n = 54) or definite AP (n = 298). Results. Multivariate Cox regression analysis showed that significant factors associated with mortality were age, alcohol, and diabetes, whereas female gender, co-living and employment were associated with better survival. The S-amylase level had no impact on mortality. The most frequent causes of death were cardiovascular diseases, digestive diseases, and malignancies. Conclusions. Age, alcohol and diabetes had a significant impact on survival whereas the S-amylase level did not.

U2 - 10.3109/00365521.2010.537686

DO - 10.3109/00365521.2010.537686

M3 - Journal article

C2 - 21091094

SN - 0036-5521

VL - 46

SP - 495

EP - 502

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

IS - 4

ER -