Exposure to sunshine early in life prevented development of type 1 diabetes in Danish boys

TY - JOUR

T1 - Exposure to sunshine early in life prevented development of type 1 diabetes in Danish boys

AU - Jacobsen, Ramune

AU - Frederiksen, Peder

AU - Heitmann, Berit L.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - BACKGROUND: We aimed to assess the association between exposure to sunshine during gestation and the risk of type 1 diabetes (T1D) in Danish children.METHODS: The study population included 331,623 individuals born in Denmark from 1983 to 1988; 886 (0.26%) developed T1D by the age of 15 years. The values of sunshine hours were obtained from the Danish Meteorological Institute. Gestational exposure to sunshine was calculated by summing recorded monthly sunshine hours during the full 9 months prior to the month of birth. The linear variable then was split into two categories separated by the median value.RESULTS AND CONCLUSIONS: Cox regression models showed that more sunshine during the third gestational trimester was associated with lower hazards (HR) of T1D at age 5-9 years in males: HR (95% CI): 0.60 (0.43-0.84), p=0.003. Our results should be considered in the context of evidence-based recommendations to the public about skin protection from the sun.

AB - BACKGROUND: We aimed to assess the association between exposure to sunshine during gestation and the risk of type 1 diabetes (T1D) in Danish children.METHODS: The study population included 331,623 individuals born in Denmark from 1983 to 1988; 886 (0.26%) developed T1D by the age of 15 years. The values of sunshine hours were obtained from the Danish Meteorological Institute. Gestational exposure to sunshine was calculated by summing recorded monthly sunshine hours during the full 9 months prior to the month of birth. The linear variable then was split into two categories separated by the median value.RESULTS AND CONCLUSIONS: Cox regression models showed that more sunshine during the third gestational trimester was associated with lower hazards (HR) of T1D at age 5-9 years in males: HR (95% CI): 0.60 (0.43-0.84), p=0.003. Our results should be considered in the context of evidence-based recommendations to the public about skin protection from the sun.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1515/jpem-2015-0393

DO - 10.1515/jpem-2015-0393

M3 - Journal article

C2 - 26673019

SN - 0334-018X

VL - 29

SP - 417

EP - 424

JO - Journal of Pediatric Endocrinology and Metabolism

JF - Journal of Pediatric Endocrinology and Metabolism

IS - 4

ER -