TY - JOUR
T1 - Exposure to loud noise and risk of vestibular schwannoma
T2 - results from the INTERPHONE international case‒control study
AU - Deltour, Isabelle
AU - Schlehofer, Brigitte
AU - Massardier-Pilonchéry, Amélie
AU - Schlaefer, Klaus
AU - Armstrong, Bruce
AU - Giles, Graham G
AU - Siemiatycki, Jack
AU - Parent, Marie-Elise
AU - Krewski, Daniel
AU - McBride, Mary
AU - Johansen, Christoffer
AU - Auvinen, Anssi
AU - Salminen, Tiina
AU - Hours, Martine
AU - Montestrucq, Lucile
AU - Blettner, Maria
AU - Berg-Beckhoff, Gabriele
AU - Sadetzki, Siegal
AU - Chetrit, Angela
AU - Lagorio, Susanna
AU - Iavarone, Ivano
AU - Yamaguchi, Naohito
AU - Takebayashi, Toru
AU - Woodward, Alistair
AU - Cook, Angus
AU - Tynes, Tore
AU - Klaeboe, Lars
AU - Maria Feychting, Maria Feychting
AU - Lönn, Stefan
AU - Fleming, Sarah
AU - Swerdlow, Anthony J
AU - Schoemaker, Minouk J
AU - Moissonnier, Monika
AU - Kesminiene, Ausrele
AU - Cardis, Elisabeth
AU - Schüz, Joachim
AU - INTERPHONE Study Group
PY - 2019
Y1 - 2019
N2 - Objective Studies of loud noise exposure and vestibular schwannomas (VS) have shown conflicting results. The population-based INTERPHONE case‒control study was conducted in 13 countries during 2000-2004. In this paper, we report the results of analyses on the association between VS and self-reported loud noise exposure. Methods Self-reported noise exposure was analyzed in 1024 VS cases and 1984 matched controls. Life-long noise exposure was estimated through detailed questions. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using adjusted conditional logistic regression for matched sets. Results The OR for total work and leisure noise exposure was 1.6 (95% CI 1.4-1.9). OR were 1.5 (95% CI 1.3-1.9) for only occupational noise, 1.9 (95% CI 1.4-2.6) for only leisure noise and 1.7 (95% CI 1.2-2.2) for exposure in both contexts. OR increased slightly with increasing lag-time. For occupational exposures, duration, time since exposure start and a metric combining lifetime duration and weekly exposure showed significant trends of increasing risk with increasing exposure. OR did not differ markedly by source or other characteristics of noise. Conclusion The consistent associations seen are likely to reflect either recall bias or a causal association, or potentially indicate a mixture of both.
AB - Objective Studies of loud noise exposure and vestibular schwannomas (VS) have shown conflicting results. The population-based INTERPHONE case‒control study was conducted in 13 countries during 2000-2004. In this paper, we report the results of analyses on the association between VS and self-reported loud noise exposure. Methods Self-reported noise exposure was analyzed in 1024 VS cases and 1984 matched controls. Life-long noise exposure was estimated through detailed questions. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using adjusted conditional logistic regression for matched sets. Results The OR for total work and leisure noise exposure was 1.6 (95% CI 1.4-1.9). OR were 1.5 (95% CI 1.3-1.9) for only occupational noise, 1.9 (95% CI 1.4-2.6) for only leisure noise and 1.7 (95% CI 1.2-2.2) for exposure in both contexts. OR increased slightly with increasing lag-time. For occupational exposures, duration, time since exposure start and a metric combining lifetime duration and weekly exposure showed significant trends of increasing risk with increasing exposure. OR did not differ markedly by source or other characteristics of noise. Conclusion The consistent associations seen are likely to reflect either recall bias or a causal association, or potentially indicate a mixture of both.
U2 - 10.5271/sjweh.3781
DO - 10.5271/sjweh.3781
M3 - Journal article
C2 - 30614502
SN - 0355-3140
VL - 45
SP - 183
EP - 193
JO - Scandinavian Journal of Work, Environment & Health
JF - Scandinavian Journal of Work, Environment & Health
IS - 2
ER -