Exposure determinants of cadmium in European mothers and their children

Marika Berglund; Kristin Larsson; Margaretha Grandér; Ludwine Casteleyn; Marike Kolossa-Gehring; Gerda Schwedler; Argelia Castaño; Marta Esteban; Jürgen Angerer; Holger M Koch; Birgit K Schindler; Greet Schoeters; Roel Smolders; Karen Exley; Ovnair Sepai; Luies Blumen; Milena Horvat; Lisbeth E. Knudsen; Thit A Mørck; Anke Joas; Reinhard Joas; Pierre Biot; Dominique Aerts; Koen De Cremer; Ilse Van Overmeire; Andromachi Katsonouri; Adamos Hadjipanayis; Milena Cerna; Andrea Krskova; Jeanette K S Nielsen; Janne Fangel Jensen; Peter Rudnai; Szilvia Kozepesy; Chris Griffin; Ian Nesbitt; Arno C Gutleb; Marc E Fischer; Danuta Ligocka; Marek Jakubowski; M Fátima Reis; Sónia Namorado; Ioana-Rodica Lupsa; Anca E Gurzau; Katarina Halzlova; Michal Jajcaj; Darja Mazej; Janja Snoj Tratnik; Ana Lopez; Ana Cañas; Andrea Lehmann; Pierre Crettaz; Elly Den Hond; Eva Govarts

doi:10.1016/j.envres.2014.09.042

Exposure determinants of cadmium in European mothers and their children

Marika Berglund, Kristin Larsson, Margaretha Grandér, Ludwine Casteleyn, Marike Kolossa-Gehring, Gerda Schwedler, Argelia Castaño, Marta Esteban, Jürgen Angerer, Holger M Koch, Birgit K Schindler, Greet Schoeters, Roel Smolders, Karen Exley, Ovnair Sepai, Luies Blumen, Milena Horvat, Lisbeth E. Knudsen, Thit A Mørck, Anke JoasReinhard Joas, Pierre Biot, Dominique Aerts, Koen De Cremer, Ilse Van Overmeire, Andromachi Katsonouri, Adamos Hadjipanayis, Milena Cerna, Andrea Krskova, Jeanette K S Nielsen, Janne Fangel Jensen, Peter Rudnai, Szilvia Kozepesy, Chris Griffin, Ian Nesbitt, Arno C Gutleb, Marc E Fischer, Danuta Ligocka, Marek Jakubowski, M Fátima Reis, Sónia Namorado, Ioana-Rodica Lupsa, Anca E Gurzau, Katarina Halzlova, Michal Jajcaj, Darja Mazej, Janja Snoj Tratnik, Ana Lopez, Ana Cañas, Andrea Lehmann, Pierre Crettaz, Elly Den Hond, Eva Govarts

35 Citationer (Scopus)

Abstract

The metal cadmium (Cd) is a widespread environmental pollutant with documented adverse effects on the kidneys and bones from long-term environmental exposure, but with insufficiently elucidated public health consequences such as risk of cardiovascular disease, hormone-related cancer in adults and developmental effects in children. This study is the first pan-European human biomonitoring project that succeeded in performing harmonized measurements of Cd in urine in a comparable way in mother-child couples from 16 European countries. The aim of the study was to evaluate the overall Cd exposure and significant determinants of Cd exposure. A study population of 1632 women (24-52 years of age), and 1689 children (5-12 years of age), from 32 rural and urban areas, was examined within a core period of 6 months in 2011-2012. Women were stratified as smokers and non-smokers. As expected, smoking mothers had higher geometric mean (gm) urinary cadmium (UCd; 0.24µg/g crea; n=360) than non-smoking mothers (gm 0.18µg/g crea; n=1272; p<0.0001), and children had lower UCd (gm 0.065µg/g crea; n=1689) than their mothers at the country level. Non-smoking women exposed to environmental tobacco smoke (ETS) at home had 14% (95% CI 1-28%) higher UCd than those who were not exposed to ETS at home (p=0.04). No influence of ETS at home or other places on UCd levels was detected in children. Smoking women with primary education as the highest educational level of the household had 48% (95% CI 18-86%) higher UCd than those with tertiary education (p=0.0008). The same observation was seen in non-smoking women and in children; however they were not statistically significant. In children, living in a rural area was associated with 7% (95% CI 1-13%) higher UCd (p=0.03) compared to living in an urban area. Children, 9-12 years had 7% (95% CI 1-13%) higher UCd (p=0.04) than children 5-8 years. About 1% of the mothers, and 0.06% of the children, exceeded the tolerable weekly intake (TWI) appointed by EFSA, corresponding to 1.0µgCd/g crea in urine. Poland had the highest UCd in comparison between the 16 countries, while Denmark had the lowest. Whether the differences between countries are related to differences in the degree of environmental Cd contamination or to differences in lifestyle, socioeconomic status or dietary patterns is not clear.

Originalsprog	Engelsk
Tidsskrift	Environmental Research
Vol/bind	141
Sider (fra-til)	69-76
Antal sider	8
ISSN	0013-9351
DOI	https://doi.org/10.1016/j.envres.2014.09.042
Status	Udgivet - 1 aug. 2015

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10.1016/j.envres.2014.09.042Licens: CC BY-NC-ND

Citationsformater

Berglund, M., Larsson, K., Grandér, M., Casteleyn, L., Kolossa-Gehring, M., Schwedler, G., Castaño, A., Esteban, M., Angerer, J., Koch, H. M., Schindler, B. K., Schoeters, G., Smolders, R., Exley, K., Sepai, O., Blumen, L., Horvat, M., Knudsen, L. E., Mørck, T. A., ... Govarts, E. (2015). Exposure determinants of cadmium in European mothers and their children. Environmental Research, 141, 69-76. https://doi.org/10.1016/j.envres.2014.09.042

Berglund, M, Larsson, K, Grandér, M, Casteleyn, L, Kolossa-Gehring, M, Schwedler, G, Castaño, A, Esteban, M, Angerer, J, Koch, HM, Schindler, BK, Schoeters, G, Smolders, R, Exley, K, Sepai, O, Blumen, L, Horvat, M, Knudsen, LE, Mørck, TA, Joas, A, Joas, R, Biot, P, Aerts, D, De Cremer, K, Van Overmeire, I, Katsonouri, A, Hadjipanayis, A, Cerna, M, Krskova, A, Nielsen, JKS, Jensen, JF, Rudnai, P, Kozepesy, S, Griffin, C, Nesbitt, I, Gutleb, AC, Fischer, ME, Ligocka, D, Jakubowski, M, Reis, MF, Namorado, S, Lupsa, I-R, Gurzau, AE, Halzlova, K, Jajcaj, M, Mazej, D, Tratnik, JS, Lopez, A, Cañas, A, Lehmann, A, Crettaz, P, Hond, ED & Govarts, E 2015, 'Exposure determinants of cadmium in European mothers and their children', Environmental Research, bind 141, s. 69-76. https://doi.org/10.1016/j.envres.2014.09.042

@article{bae0b951056e44ee856934a541f2af3b,

title = "Exposure determinants of cadmium in European mothers and their children",

abstract = "The metal cadmium (Cd) is a widespread environmental pollutant with documented adverse effects on the kidneys and bones from long-term environmental exposure, but with insufficiently elucidated public health consequences such as risk of cardiovascular disease, hormone-related cancer in adults and developmental effects in children. This study is the first pan-European human biomonitoring project that succeeded in performing harmonized measurements of Cd in urine in a comparable way in mother-child couples from 16 European countries. The aim of the study was to evaluate the overall Cd exposure and significant determinants of Cd exposure. A study population of 1632 women (24-52 years of age), and 1689 children (5-12 years of age), from 32 rural and urban areas, was examined within a core period of 6 months in 2011-2012. Women were stratified as smokers and non-smokers. As expected, smoking mothers had higher geometric mean (gm) urinary cadmium (UCd; 0.24µg/g crea; n=360) than non-smoking mothers (gm 0.18µg/g crea; n=1272; p<0.0001), and children had lower UCd (gm 0.065µg/g crea; n=1689) than their mothers at the country level. Non-smoking women exposed to environmental tobacco smoke (ETS) at home had 14% (95% CI 1-28%) higher UCd than those who were not exposed to ETS at home (p=0.04). No influence of ETS at home or other places on UCd levels was detected in children. Smoking women with primary education as the highest educational level of the household had 48% (95% CI 18-86%) higher UCd than those with tertiary education (p=0.0008). The same observation was seen in non-smoking women and in children; however they were not statistically significant. In children, living in a rural area was associated with 7% (95% CI 1-13%) higher UCd (p=0.03) compared to living in an urban area. Children, 9-12 years had 7% (95% CI 1-13%) higher UCd (p=0.04) than children 5-8 years. About 1% of the mothers, and 0.06% of the children, exceeded the tolerable weekly intake (TWI) appointed by EFSA, corresponding to 1.0µgCd/g crea in urine. Poland had the highest UCd in comparison between the 16 countries, while Denmark had the lowest. Whether the differences between countries are related to differences in the degree of environmental Cd contamination or to differences in lifestyle, socioeconomic status or dietary patterns is not clear.",

author = "Marika Berglund and Kristin Larsson and Margaretha Grand{\'e}r and Ludwine Casteleyn and Marike Kolossa-Gehring and Gerda Schwedler and Argelia Casta{\~n}o and Marta Esteban and J{\"u}rgen Angerer and Koch, {Holger M} and Schindler, {Birgit K} and Greet Schoeters and Roel Smolders and Karen Exley and Ovnair Sepai and Luies Blumen and Milena Horvat and Knudsen, {Lisbeth E.} and M{\o}rck, {Thit A} and Anke Joas and Reinhard Joas and Pierre Biot and Dominique Aerts and {De Cremer}, Koen and {Van Overmeire}, Ilse and Andromachi Katsonouri and Adamos Hadjipanayis and Milena Cerna and Andrea Krskova and Nielsen, {Jeanette K S} and Jensen, {Janne Fangel} and Peter Rudnai and Szilvia Kozepesy and Chris Griffin and Ian Nesbitt and Gutleb, {Arno C} and Fischer, {Marc E} and Danuta Ligocka and Marek Jakubowski and Reis, {M F{\'a}tima} and S{\'o}nia Namorado and Ioana-Rodica Lupsa and Gurzau, {Anca E} and Katarina Halzlova and Michal Jajcaj and Darja Mazej and Tratnik, {Janja Snoj} and Ana Lopez and Ana Ca{\~n}as and Andrea Lehmann and Pierre Crettaz and Hond, {Elly Den} and Eva Govarts",

year = "2015",

month = aug,

day = "1",

doi = "10.1016/j.envres.2014.09.042",

language = "English",

volume = "141",

pages = "69--76",

journal = "Environmental Research",

issn = "0013-9351",

publisher = "Academic Press",

}

TY - JOUR

T1 - Exposure determinants of cadmium in European mothers and their children

AU - Berglund, Marika

AU - Larsson, Kristin

AU - Grandér, Margaretha

AU - Casteleyn, Ludwine

AU - Kolossa-Gehring, Marike

AU - Schwedler, Gerda

AU - Castaño, Argelia

AU - Esteban, Marta

AU - Angerer, Jürgen

AU - Koch, Holger M

AU - Schindler, Birgit K

AU - Schoeters, Greet

AU - Smolders, Roel

AU - Exley, Karen

AU - Sepai, Ovnair

AU - Blumen, Luies

AU - Horvat, Milena

AU - Knudsen, Lisbeth E.

AU - Mørck, Thit A

AU - Joas, Anke

AU - Joas, Reinhard

AU - Biot, Pierre

AU - Aerts, Dominique

AU - De Cremer, Koen

AU - Van Overmeire, Ilse

AU - Katsonouri, Andromachi

AU - Hadjipanayis, Adamos

AU - Cerna, Milena

AU - Krskova, Andrea

AU - Nielsen, Jeanette K S

AU - Jensen, Janne Fangel

AU - Rudnai, Peter

AU - Kozepesy, Szilvia

AU - Griffin, Chris

AU - Nesbitt, Ian

AU - Gutleb, Arno C

AU - Fischer, Marc E

AU - Ligocka, Danuta

AU - Jakubowski, Marek

AU - Reis, M Fátima

AU - Namorado, Sónia

AU - Lupsa, Ioana-Rodica

AU - Gurzau, Anca E

AU - Halzlova, Katarina

AU - Jajcaj, Michal

AU - Mazej, Darja

AU - Tratnik, Janja Snoj

AU - Lopez, Ana

AU - Cañas, Ana

AU - Lehmann, Andrea

AU - Crettaz, Pierre

AU - Hond, Elly Den

AU - Govarts, Eva

PY - 2015/8/1

Y1 - 2015/8/1

N2 - The metal cadmium (Cd) is a widespread environmental pollutant with documented adverse effects on the kidneys and bones from long-term environmental exposure, but with insufficiently elucidated public health consequences such as risk of cardiovascular disease, hormone-related cancer in adults and developmental effects in children. This study is the first pan-European human biomonitoring project that succeeded in performing harmonized measurements of Cd in urine in a comparable way in mother-child couples from 16 European countries. The aim of the study was to evaluate the overall Cd exposure and significant determinants of Cd exposure. A study population of 1632 women (24-52 years of age), and 1689 children (5-12 years of age), from 32 rural and urban areas, was examined within a core period of 6 months in 2011-2012. Women were stratified as smokers and non-smokers. As expected, smoking mothers had higher geometric mean (gm) urinary cadmium (UCd; 0.24µg/g crea; n=360) than non-smoking mothers (gm 0.18µg/g crea; n=1272; p<0.0001), and children had lower UCd (gm 0.065µg/g crea; n=1689) than their mothers at the country level. Non-smoking women exposed to environmental tobacco smoke (ETS) at home had 14% (95% CI 1-28%) higher UCd than those who were not exposed to ETS at home (p=0.04). No influence of ETS at home or other places on UCd levels was detected in children. Smoking women with primary education as the highest educational level of the household had 48% (95% CI 18-86%) higher UCd than those with tertiary education (p=0.0008). The same observation was seen in non-smoking women and in children; however they were not statistically significant. In children, living in a rural area was associated with 7% (95% CI 1-13%) higher UCd (p=0.03) compared to living in an urban area. Children, 9-12 years had 7% (95% CI 1-13%) higher UCd (p=0.04) than children 5-8 years. About 1% of the mothers, and 0.06% of the children, exceeded the tolerable weekly intake (TWI) appointed by EFSA, corresponding to 1.0µgCd/g crea in urine. Poland had the highest UCd in comparison between the 16 countries, while Denmark had the lowest. Whether the differences between countries are related to differences in the degree of environmental Cd contamination or to differences in lifestyle, socioeconomic status or dietary patterns is not clear.

AB - The metal cadmium (Cd) is a widespread environmental pollutant with documented adverse effects on the kidneys and bones from long-term environmental exposure, but with insufficiently elucidated public health consequences such as risk of cardiovascular disease, hormone-related cancer in adults and developmental effects in children. This study is the first pan-European human biomonitoring project that succeeded in performing harmonized measurements of Cd in urine in a comparable way in mother-child couples from 16 European countries. The aim of the study was to evaluate the overall Cd exposure and significant determinants of Cd exposure. A study population of 1632 women (24-52 years of age), and 1689 children (5-12 years of age), from 32 rural and urban areas, was examined within a core period of 6 months in 2011-2012. Women were stratified as smokers and non-smokers. As expected, smoking mothers had higher geometric mean (gm) urinary cadmium (UCd; 0.24µg/g crea; n=360) than non-smoking mothers (gm 0.18µg/g crea; n=1272; p<0.0001), and children had lower UCd (gm 0.065µg/g crea; n=1689) than their mothers at the country level. Non-smoking women exposed to environmental tobacco smoke (ETS) at home had 14% (95% CI 1-28%) higher UCd than those who were not exposed to ETS at home (p=0.04). No influence of ETS at home or other places on UCd levels was detected in children. Smoking women with primary education as the highest educational level of the household had 48% (95% CI 18-86%) higher UCd than those with tertiary education (p=0.0008). The same observation was seen in non-smoking women and in children; however they were not statistically significant. In children, living in a rural area was associated with 7% (95% CI 1-13%) higher UCd (p=0.03) compared to living in an urban area. Children, 9-12 years had 7% (95% CI 1-13%) higher UCd (p=0.04) than children 5-8 years. About 1% of the mothers, and 0.06% of the children, exceeded the tolerable weekly intake (TWI) appointed by EFSA, corresponding to 1.0µgCd/g crea in urine. Poland had the highest UCd in comparison between the 16 countries, while Denmark had the lowest. Whether the differences between countries are related to differences in the degree of environmental Cd contamination or to differences in lifestyle, socioeconomic status or dietary patterns is not clear.

U2 - 10.1016/j.envres.2014.09.042

DO - 10.1016/j.envres.2014.09.042

M3 - Journal article

C2 - 25465922

SN - 0013-9351

VL - 141

SP - 69

EP - 76

JO - Environmental Research

JF - Environmental Research

ER -

Exposure determinants of cadmium in European mothers and their children

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